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Last update 23 Jan 2025

Induced termination of pregnancy in second trimester

Last update 23 Jan 2025

Basic Info

Synonyms

Induced termination of pregnancy in second trimester, Induced termination of pregnancy in second trimester (diagnosis), Induced termination of pregnancy in second trimester (disorder)

+ [6]

Introduction-

Drugs associated with Induced termination of pregnancy in second trimester

Mifepristone

Target

GR x PR

Mechanism

GR antagonists [+1]

Active Org.

Corcept Therapeutics, Inc. [+5]

Originator Org.

Danco Laboratories LLC

Active Indication

Induced Abortion [+6]

Inactive Indication

Adrenal Insufficiency [+13]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

United States

First Approval Date28 Sep 2000

Acrinol Hydrate

Target-

Mechanism-

Active Org.

Guangxi Hefeng Pharmaceutical Co. Ltd.

Originator Org.

Guangxi Hefeng Pharmaceutical Co. Ltd.

Active Indication

Induced termination of pregnancy in second trimester

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

China

First Approval Date01 Jan 1985

Clinical Trials associated with Induced termination of pregnancy in second trimester

IRCT20200603047648N1

/ SuspendedPhase 3IIT

Comparison of the effect of Misoprostol and Diplen with Misoprostol in cervical priming in the first and second trimesters

Start Date22 Sep 2020

Sponsor / Collaborator-

IRCT20130626013777N2

/ RecruitingPhase 2IIT

The effect of letrozole with misoprostol on induced abortion in the second trimester

Start Date13 Feb 2019

Sponsor / Collaborator-

IRCT2017082635898N1

/ CompletedNot ApplicableIIT

Comparative study of effect of misoprostol moistened with normal saline and acetic acid for14 to 26 weeks pregnant women termination.

Start Date21 Dec 2016

Sponsor / Collaborator-

100 Clinical Results associated with Induced termination of pregnancy in second trimester

100 Translational Medicine associated with Induced termination of pregnancy in second trimester

0 Patents (Medical) associated with Induced termination of pregnancy in second trimester

Literatures (Medical) associated with Induced termination of pregnancy in second trimester

01 Jul 2023·Pediatric and Developmental Pathology

Comparison of the Autopsy and Placental Findings in Second vs Third Trimester Stillbirth

Article

Author: Ernst, Linda M. ; Price, Erica ; Manjee, Kiran

Background: The pathology of second trimester fetal loss is not well-characterized due to lack of comprehensive autopsy studies. The purpose of this study is to compare autopsy pathology of second trimester and third trimester stillbirth. Methods: In this retrospective cohort study, fetal autopsies performed in-house with complete placental examination were included. From autopsy reports, maternal demographics, gestational age, sex, body and placental weight, congenital anomalies, and cause of death (COD) were obtained. Immediate COD was coded “probable” or “possible” according to Initial Causes of Fetal Death (INCODE). Results: Among 68 second trimester and 54 third trimester fetal autopsies, at least 1 probable COD was identified in 59/68 (87%) second trimester and 44/54 (81%) third trimester cases. 42/68 (62%) second trimester and 28/54 (52%) third trimester fetuses had probable COD secondary to placental pathology. Among placental causes, 29/42 (69%) second trimester and 14/28 (50%) third trimester stillbirths were related to compromised fetal microcirculation with umbilical cord abnormality. Conclusions: Among stillborn first and second trimester fetuses who undergo autopsy, the most prevalent COD is pathologic placental conditions, particularly those associated with umbilical cord obstruction. This study stresses the importance of placenta examination for establishing COD in both second and third trimester fetuses.

04 May 2023·Fetal and Pediatric Pathology

Recurrent Second Trimester Fetal Demise Caused by Hypercoiled Umbilical Cords

Article

Author: Boyd, Theonia K ; Slack, Jonathan C ; Carreon, Chrystalle Katte

BACKGROUNDUmbilical cord flow impairment accounts for a majority of fetal vascular malperfusion (FVM). Hypercoiled umbilical cords are one cause of impaired fetal blood flow that may, in severe cases, result in intrauterine fetal demise (IUFD). Although the factors involved in umbilical cord patterning are incompletely understood, a limited number of reports have described recurrent intra-familial hypercoiling leading to death in the second trimester, suggesting a subset may have a genetic etiology.CASE REPORTSHerein, we report two additional cases of recurrent second trimester IUFD secondary to FVM due to umbilical cord hypercoiling and briefly discuss all published cases.CONCLUSIONOur cases add to a small, but growing, body of literature that suggests a genetic etiology to a subset of hypercoiled umbilical cords.

04 Jul 2022·The European Journal of Contraception & Reproductive Health CareQ4 · MEDICINE

Combination of mifepristone and misoprostol vs misoprostol monotherapy for treatment of second-trimester pregnancy loss

Q4 · MEDICINE

Article

Author: Valero, Irene ; Garcia-Jimenez, Rocio ; Weber-Fernandez, Ana Maria ; Cerrillos, Lucas ; Diaz-Acedo, Rocio ; Fobelo-Lozano, Maria Jose ; Ostos, Rosa

OBJECTIVEOur main goal was to evaluate whether a treatment protocol based on the combination of mifepristone and misoprostol for second-trimester foetal loss was more effective than misoprostol monotherapy.METHODSThis was an observational, retrospective, cross-sectional two-centre study of women receiving treatment for second-trimester pregnancy loss. Patients were recruited in two centres that used different treatment protocols: combined mifepristone-misoprostol treatment or misoprostol monotherapy.RESULTSA total of 99 patients were included in the study: 41 in the mifepristone-misoprostol combined treatment group and 58 in the misoprostol monotherapy group. The combined treatment group had shorter times to expulsion and shorter hospitalisations, as well as higher rates of hospital discharge within 24 h and complete abortion within the first 6 h and 12 h. There were no differences regarding secondary effects and complication rates.CONCLUSIONA combination of mifepristone and misoprostol appears to be a feasible option for the treatment of second-trimester pregnancy loss.

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Induced termination of pregnancy in second trimester

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