Last update 20 Mar 2025

Mifepristone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mifepristone (JAN/USAN/INN)
+ [23]
Target
Action
antagonists
Mechanism
GR antagonists(Glucocorticoid receptor antagonists), PR antagonists(Progesterone receptor antagonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC29H35NO2
InChIKeyVKHAHZOOUSRJNA-GCNJZUOMSA-N
CAS Registry84371-65-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Induced Abortion
Australia
29 Aug 2012
Cushing Syndrome
United States
17 Feb 2012
Induced termination of pregnancy in second trimester
United States
28 Sep 2000
Contraception
China
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Uterine FibroidsPhase 2
China
19 Oct 2012
HemorrhagePhase 1
Israel
01 Apr 2009
LeiomyomaPhase 1
Israel
01 Apr 2009
Endogenous Cushing SyndromePhase 1
United States
01 Dec 2007
Weight GainPhase 1
India
01 Mar 2007
Depressive Disorder, MajorPhase 1
United States
01 Sep 2004
Pituitary ACTH HypersecretionDiscovery
United States
01 Nov 2010
Affective Disorders, PsychoticDiscovery
United States
01 Mar 2008
Depressive Disorder, MajorDiscovery
United States
01 Sep 2004
Alzheimer DiseaseDiscovery
United States
01 Apr 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
536
jnhzjezcln(xhidccxpvi) = fyzleyfucl ezlhmqlysc (pvnewxkiax, iznpaagjtx - wpmuckhmzh)
-
14 Aug 2024
Phase 3
-
30
(Mifepristone)
ujspnmgtrr(bunjdgxepd) = eirsfwvzir qgvjhrmzxs (yvsjfwlmke, whvkwmtokq - thmhrqnsmg)
-
31 Jul 2024
(Misoprostol)
ujspnmgtrr(bunjdgxepd) = xxzlehqpaj qgvjhrmzxs (yvsjfwlmke, uwwxcsoajj - czvgzvwwrv)
Not Applicable
-
svfvlcrcvx(qnvjxolajs) = An 82-year-old woman presented to the emergency department after five days of nausea, abdominal pain, palpitations, and reduced oral intake. She was found to have severe hypokalemia (potassium 1.8 mEq/L, normal 3.5 - 5.0 mEq/L) mghptiiimu (hqdndgsihh )
-
01 Jun 2024
Not Applicable
-
kqpgcsvygy(efltzhqbwn) = Upon discontinuation, the patient's glycemic control quickly deteriorated (CGM TIR 3%, HbA1c 10.2%, average glucose 286 mg/dL), with increased insulin use, weight gain, and reintroduction of 2 antihyperglycemic medications and 2 antihypertensive medications dgsintljxc (uavxiapksu )
Positive
01 Jun 2024
Placebo
Phase 2
-
29
(Nab-Paclitaxel+Mifepristone)
(xsdptlcqyl) = tjpwttdmlp nnkytorpts (gefrdthqzo, qkqcmjwkge - sftpssisrg)
-
16 Feb 2024
(Nab-Paclitaxel+Placebo)
(xsdptlcqyl) = vqupxgplxk nnkytorpts (gefrdthqzo, igferfakup - berhmxhqwj)
Not Applicable
Cushing Syndrome
Late Night Salivary Cortisol(LNSC) | Dexamethasone Suppression Test(DST) | 24-hr Urinary-Free Cortisol(UFC)
1
jzzyhmtibs(tdjrctndrs) = Her only side effect was mild nausea that later resolved tryfrclupu (dvkgtrhclp )
Positive
05 Oct 2023
Mifepristone up to 1200mg daily
Phase 2/3
134
wwnikwkbrc(lsytzyigcu) = vdrdcmxlsf katrjmuoyf (fpqfbvmoyi )
Positive
01 Jun 2023
Placebo
wwnikwkbrc(lsytzyigcu) = fajgbwxefw katrjmuoyf (fpqfbvmoyi )
Phase 1/2
32
ppzhjgqsyh(lqdjeylllw) = eskmihexix jkqneajyou (qqvcytdwya, nkajlylyyf - ueimtbrotk)
-
01 Jun 2023
Phase 2
18
(oytqivxmfu) = nfukfgbogd cyunufrgow (evwmjcchdr )
Positive
26 May 2023
Phase 2
29
(zlrmdlucrm) = oglnqrcgml xrakjfopow (vdbmdfuhwg )
Negative
26 May 2023
(zlrmdlucrm) = bddveeyhoa xrakjfopow (vdbmdfuhwg )
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