Heart Septal Defects, Ventricular

THURSDAY, Jan. 25, 2024 -- The risk for congenital malformations is lower in association with buprenorphine versus methadone for opioid use disorder in pregnancy, according to a study published online Jan. 22 in JAMA Internal Medicine . Elizabeth A. Suarez, Ph.D., M.P.H., from Brigham and Women's Hospital and Harvard Medical School in Boston, and colleagues compared the risk for congenital malformations following in utero exposure to buprenorphine versus methadone in a population-based cohort study using data from publicly insured Medicaid beneficiaries from 2000 to 2018. Data were included for 13,360 pregnancies with enrollment from 90 days prior to pregnancy start through one month after delivery ; first-trimester buprenorphine or methadone use was linked to infant outcomes. Overall, 9,514 pregnancies with first-trimester buprenorphine exposure and 3,846 with methadone exposure were included in the cohort. The researchers found that the risk for malformations was 50.9 and 60.6 per 1,000 pregnancies for buprenorphine and methadone, respectively. After confounding adjustment, buprenorphine was associated with a lower risk for malformations compared with methadone (risk ratio [RR], 0.82). For buprenorphine, risk was lower for cardiac malformations (RR, 0.63), including ventricular septal defect and secundum atrial septal defect/non-prematurity-related patent foramen ovale (RRs, 0.62 and 0.54, respectively), oral clefts (RR, 0.65), and clubfoot (RR, 0.55). Given low event counts, results for neural tube defects were uncertain. "The small increase observed in the risk of malformations with methadone use compared with buprenorphine likely does not exclude methadone as the best treatment choice for some pregnant individuals, particularly those on stable treatment prior to pregnancy or patients who do not respond well to buprenorphine," the authors write. Several authors disclosed ties to industry. Abstract/Full Text (subscription or payment may be required) Editorial (subscription or payment may be required) Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions. Posted January 2024 More news resources FDA Medwatch Drug Alerts Daily MedNews News for Health Professionals New Drug Approvals New Drug Applications Drug Shortages Clinical Trial Results Generic Drug Approvals Subscribe to our newsletter Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

HYDERABAD, India, July 20, 2023 /PRNewswire/ -- A baby Mustalfo Abdirisak Ahmed, 11 months female weighing 7 kg successfully underwent the VSD Device Closure procedure at Medicover Hospitals. The baby is now hale and hearty and has achieved a milestone within a week by walking independently. Continue Reading Dr Ashish Sapre - Consultant Paediatric Cardiologist with 11 months Old baby Patient The Dr Ashish Sapre, Consultant Interventional Pediatric Cardiologist, said, "This baby patient was suffering from a hole in the heart known as a ventricular septal defect (VSD). It is a common congenital (present at birth) heart condition. Earlier, the baby was advised for open heart surgery in the parent country and at different institutions in the city. But after multiple sessions and exhaustive counseling, the parents were convinced of catheter intervention. The procedure went smoothly, and the patient was discharged the next day. When they came for a follow-up visit one week after the procedure, the child was doing fine, with no scars and all smiles and the parents were happy with the baby's recovery and health. She probably must be the youngest to date at Medicover Hospitals to get the VSD Device Closure procedure done." The doctor also expressed gratitude to the international marketing team, the cathlab staff, the excellent anesthetic Dr Pavan & whole team. Medicover Hospitals is equipped with state-of-the-art NICU and PICU facilities backed by advanced intensive care units, highly experienced pediatric cardiologists and a pediatric heart surgery team. The happy parents thanked the doctors and the hospital for giving their child a new lease of life. About the Company Medicover is the leading Multispecialty Hospital chain in India. It is one of the largest healthcare providers in Europe with a significant presence in India. Medicover Hospitals is spread across 16 cities of Telangana, Andhra Pradesh, and Maharashtra with 5500 + beds ,20 Cath labs, 1200 + Consultants treating millions of patients every year with a clear focus on raising the standards of health care in India. It has renowned medical teams who work with the greatest technologies and international evidence-based protocols which offer the most comprehensive treatment across all specialities. Contact 040-68334455 Photo: SOURCE Medicover Hospitals

HYDERABAD, India, July 20, 2023 /PRNewswire/ -- A baby Mustalfo Abdirisak Ahmed, 11 months female weighing 7 kg successfully underwent the VSD Device Closure procedure at Medicover Hospitals. The baby is now hale and hearty and has achieved a milestone within a week by walking independently. Continue Reading Dr Ashish Sapre - Consultant Paediatric Cardiologist with 11 months Old baby Patient The Dr Ashish Sapre, Consultant Interventional Pediatric Cardiologist, said, "This baby patient was suffering from a hole in the heart known as a ventricular septal defect (VSD). It is a common congenital (present at birth) heart condition. Earlier, the baby was advised for open heart surgery in the parent country and at different institutions in the city. But after multiple sessions and exhaustive counseling, the parents were convinced of catheter intervention. The procedure went smoothly, and the patient was discharged the next day. When they came for a follow-up visit one week after the procedure, the child was doing fine, with no scars and all smiles and the parents were happy with the baby's recovery and health. She probably must be the youngest to date at Medicover Hospitals to get the VSD Device Closure procedure done." The doctor also expressed gratitude to the international marketing team, the cathlab staff, the excellent anesthetic Dr Pavan & whole team. Medicover Hospitals is equipped with state-of-the-art NICU and PICU facilities backed by advanced intensive care units, highly experienced pediatric cardiologists and a pediatric heart surgery team. The happy parents thanked the doctors and the hospital for giving their child a new lease of life. About the Company Medicover is the leading Multispecialty Hospital chain in India. It is one of the largest healthcare providers in Europe with a significant presence in India. Medicover Hospitals is spread across 16 cities of Telangana, Andhra Pradesh, and Maharashtra with 5500 + beds ,20 Cath labs, 1200 + Consultants treating millions of patients every year with a clear focus on raising the standards of health care in India. It has renowned medical teams who work with the greatest technologies and international evidence-based protocols which offer the most comprehensive treatment across all specialities. Contact 040-68334455 Photo: SOURCE Medicover Hospitals