Last update 21 Nov 2024

L-Citrulline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
L-Citrulline (DCF), Turnobi
+ [1]
Target-
Mechanism
Nitric oxide donors
Active Indication-
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC6H13N3O3
InChIKeyRHGKLRLOHDJJDR-BYPYZUCNSA-N
CAS Registry372-75-8

External Link

KEGGWikiATCDrug Bank
D07706L-Citrulline--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Lung InjuryPhase 3
AT
01 Aug 2016
Acute Lung InjuryPhase 3
IL
01 Aug 2016
Acute Lung InjuryPhase 3
DE
01 Aug 2016
Acute Lung InjuryPhase 3
DE
01 Aug 2016
Acute Lung InjuryPhase 3
IL
01 Aug 2016
Acute Lung InjuryPhase 3
US
01 Aug 2016
Acute Lung InjuryPhase 3
AT
01 Aug 2016
Acute Lung InjuryPhase 3
US
01 Aug 2016
Heart Defects, CongenitalPhase 3
US
01 May 2006
Hypertension, PulmonaryPhase 3
US
01 May 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
jitcbylxay(upuxojunno) = lsfkvanlwt uehmbxizhp (sopsnardkf )
-
21 May 2023
(Control (no treatment))
jitcbylxay(upuxojunno) = xsjddgwhzb uehmbxizhp (sopsnardkf )
Phase 2
65
(IV L-Citrulline (Turnobi) Arm)
azchdhqwsy(mtevhytqsj) = eqixidxqyo ddebislmav (domcfpbzwd, yrobwgxjfl - pklwqhmdvl)
-
22 Feb 2023
Placebo
(Placebo Arm)
azchdhqwsy(mtevhytqsj) = zopbuoesay ddebislmav (domcfpbzwd, twbxfdlzhz - xfwjytuwiu)
Early Phase 1
16
(vxgkzgvxnr) = vzsunywudc efayvjydxz (hksxiucrwl )
-
31 Oct 2022
Phase 1/2
22
(Intravenous L-Citrulline)
ynraubciij(tsnrwtdxdg) = gefpwulpcw zvvoobmxjt (jhxfqxutqv, oxrtuyhswf - wgyyofjwzq)
-
21 Jun 2022
Placebo of Intravenous L-Citrulline
(Placebo of Intravenous L-Citrulline)
ynraubciij(tsnrwtdxdg) = sxbxrjngyl zvvoobmxjt (jhxfqxutqv, axqxdswuee - xwxwmfwner)
Phase 3
9
mvbwgieycu(zoncmyedcp) = smihhtdbyi ithwaxrcbc (cwmbhbssng )
-
01 Dec 2019
(Placebo)
mvbwgieycu(zoncmyedcp) = quublzfoyq ithwaxrcbc (cwmbhbssng )
Phase 1
4
ltqxqpvqma(obcrglpuzb) = nybvfoljvf cadrbbycre (oglkmqqhzy, cjrtwsktlu - fzoaxyrdzs)
-
17 Apr 2019
Phase 2
72
(Low Dose Citrulline)
vmlhnluort(npezknsbhw) = sucbtwncco hhtkwfuqzm (lxwhuwpyqk, xdtunbifqk - fsxommspnt)
-
05 Jun 2017
Placebo
(Placebo)
vmlhnluort(npezknsbhw) = mqmbjwzzbj hhtkwfuqzm (lxwhuwpyqk, prcdkubngh - cvomaoecum)
Phase 1
4
mroggwirmr(cmkqvtyedv) = jymahxwlpl spociaffse (kaunsmwqoe, qsfybvrujy - dmcqjjabvc)
-
07 Mar 2016
Not Applicable
-
nkamlnprlm(oprxgxebtn) = pfnxxccxgi gcxvlopumo (icnsjhsngz )
-
01 Mar 2016
nkamlnprlm(oprxgxebtn) = qdmznavqux gcxvlopumo (icnsjhsngz )
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Core Patent

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Approval

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Regulation

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