Last update 01 Nov 2024

Potassium Deficiency

Last update 01 Nov 2024

Basic Info

Synonyms

Deficiencies, Potassium, Deficiency, Potassium, K deficiency

+ [20]

Introduction

A condition due to decreased dietary intake of potassium, as in starvation or failure to administer in intravenous solutions, or to gastrointestinal loss in diarrhea, chronic laxative abuse, vomiting, gastric suction, or bowel diversion. Severe potassium deficiency may produce muscular weakness and lead to paralysis and respiratory failure. Muscular malfunction may result in hypoventilation, paralytic ileus, hypotension, muscle twitches, tetany, and rhabomyolysis. Nephropathy from potassium deficit impairs the concentrating mechanism, producing POLYURIA and decreased maximal urinary concentrating ability with secondary POLYDIPSIA. (Merck Manual, 16th ed)

Drugs associated with Potassium Deficiency

Potassium Chloride

Target-

Mechanism-

Active Org.

Genus Lifesciences, Inc. [+4]

Originator Org.

Eli Lilly & Co.

Active Indication

Potassium Deficiency [+2]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date06 Mar 1970

Clinical Trials associated with Potassium Deficiency

NCT05975632 / RecruitingNot Applicable

GAMMA Study: Patient Self-testing of Capillary Blood Potassium: A Validation Study and Measurement Performance in Patients.

Multicentre, open, prospective and interventional study investigating the CardioRenal device in capillary blood of patients.It will be conducted at multiple investigational sites.

Start Date02 Aug 2023

Sponsor / Collaborator

CardioRenal

NCT04907773 / CompletedNot Applicable

Evaluation of a Blood Potassium Measurement Device From Capillary Samples

This is an open, prospective, and interventional study investigating the potassium measurement with the CardioRenal device in capillary blood. It will be conducted at one investigational site.
Each subject will have capillary blood collections. Additionally as a reference a venous blood collection will be conducted

Start Date01 Jul 2021

Sponsor / Collaborator

CardioRenal

NCT05385640 / CompletedNot ApplicableIIT

Serum Potassium as a Predictor of Clinical Outcomes in an Older Patient Cohort With Chronic Postsurgical Pain: Retrospective Analysis of A Multi-Center Prospective Database in China

Perioperative serum potassium in patients over 65 impacts recovery, quality of life and physical functioning. While perioperative serum potassium is an important preoperative risk factor for poor surgical outcomes in older adults, the relationship between perioperative serum potassium and postsurgical pain in this population has not been investigated. The investigators hypothesized that preoperative serum potassium would be associated with greater odds of postsurgical chronic pain.

Start Date01 Apr 2020

Sponsor / Collaborator

Chinese People's Liberation Army General Hospital

[+6]

100 Clinical Results associated with Potassium Deficiency

100 Translational Medicine associated with Potassium Deficiency

0 Patents (Medical) associated with Potassium Deficiency

1,098

Literatures (Medical) associated with Potassium Deficiency

01 Dec 2024·Data in Brief

Dataset of infected date palm leaves for palm tree disease detection and classification

Article

Author: Alkhodre, Ahmad B ; Namoun, Abdallah ; Almoamari, Hani ; Sen, Adnan Ahmad Abi ; Alkhodre, Ahmad B. ; Alsaawy, Yazed

This article presents an image dataset of palm leaf diseases to aid the early identification and classification of date palm infections. The dataset contains images of 8 main types of disorders affecting date palm leaves, three of which are physiological, four are fungal, and one is caused by pests. Specifically, the collected samples exhibit symptoms and signs of potassium deficiency, manganese deficiency, magnesium deficiency, black scorch, leaf spots, fusarium wilt, rachis blight, and parlatoria blanchardi. Moreover, the dataset includes a baseline of healthy palm leaves. In total, 608 raw images were captured over a period of three months, coinciding with the autumn and spring seasons, from 10 real date farms in the Madinah region of Saudi Arabia. The images were captured using smartphones and an SLR camera, focusing mainly on inflected leaves and leaflets. Date palm fruits, trunks, and roots are beyond the focus of this dataset. The infected leaf images were filtered, cropped, augmented, and categorized into their disease classes. The resulting processed dataset comprises 3089 images. Our proposed dataset can be used to train classification deep learning models of infected date palm leaves, thus enabling the early prevention of palm tree-related diseases.

01 Oct 2024·European Journal of Medical Genetics

Digital clubbing without hypoxia for lysinuric protein intolerance

Article

Author: Suzuki, Hisato ; Nakato, Daisuke ; Yamada, Mamiko ; Tsujioka, Yuko ; Ohnishi, Takuma ; Watanabe, Daisuke ; Tamai, Naotaka ; Kijima, Toshihide ; Miya, Fuyuki ; Kosaki, Kenjiro ; Takenouchi, Toshiki ; Narumi, Satoshi

Digital clubbing is characterized by bulbous enlargement of the terminal segments of the fingers. Hypotheses including hypoxia have been proposed for the pathogenesis of digital clubbing, but the exact pathogenesis of digital clubbing is still uncertain. Lysinuric protein intolerance (LPI) is caused by pathogenic variants in SLC7A7 and is often associated with interstitial lung disease. Previously two patients of LPI with digital clubbing but without hypoxia have been reported. It is unclear whether digital clubbing in LPI is secondary to hypoxia or directly related to SLC7A7 deficiency. Here we report a 6-year-old Japanese boy presented with digital clubbing without hypoxia. He had episodic vomiting, each episode consisting of a single vomiting event occurring once a month, and his growth had been delayed. He had interstitial lung disease and hepatomegaly. He had compound heterozygous pathogenic variants in the SLC7A7, leading to the diagnosis of LPI. Together with the two previously reported patients mentioned above, we conclude that digital clubbing can occur in the absence of hypoxia. Digital clubbing in the absence of hypoxia has been observed in two genetic disorders related to prostaglandin (PG) E2, HPGD and SLCO2A1. PGE2 synthesis is primarily regulated by the cyclooxygenase 2, which plays a critical role in the control of inflammation. A high urine PGE level in the patient was compatible with the notion that PGE2 production may be increased in LPI. The occurrence of digital clubbing in the absence of hypoxia in LPI patients with SLC7A7 may be attributed to the mechanism of increased PGE2 production.

25 Sep 2024·Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

[Comprehensive evaluation of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy in obese patients based on efficacy and nutrition].

Article

Author: Xiao, M H ; Wang, L ; Zhang, Z H ; Jiang, T ; Cui, L ; Li, S X ; Wei, Z Q ; Liu, Y ; Zhang, Z ; Hu, L F

Objective: To evaluate the 1-year postoperative efficacy and nutritional indicators of single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) in obese patients. Methods: This retrospective observational study included patients with a body mass index (BMI) of ≥40.0 kg/m² regardless of other related metabolic diseases and patients with severe type 2 diabetes and a BMI between 27.5 and 40.0 kg/m². The clinical data of 66 obese patients who underwent SADI-S at the Bariatric and Metabolic Surgery Department of China-Japan Union Hospital of Jilin University from November 2018 to May 2022 were collected, including 53 cases of da Vinci robotic surgery and 13 cases of laparoscopic surgery. The patients comprised 38 men and 28 women with a median age of 35 (18-61) years and a mean preoperative BMI of 42.93 ± 6.82 kg/m². A total of 38 patients had type 2 diabetes, and 46 had hyperuricemia, 45 had hypertension, 35 had hyperlipidemia, 12 had hypercholesterolemia, and 12 had a high low-density lipoprotein (LDL) level. The main observation indicators were (1) intraoperative and postoperative conditions; (2) weight loss outcomes, including body weight, BMI, excess body weight loss (%EWL), and total body weight loss (%TWL) at 3, 6, and 12 months after surgery; (3) effects of treatment on metabolic disease; and (4) changes in nutrient indicators. Results: (1) Intraoperative and postoperative conditions: All patients successfully underwent SADI-S with neither conversion to laparotomy nor death. Four (6.1%) patients developed postoperative complications, and all of them recovered and were discharged after conservative or surgical treatment. (2) Weight loss outcomes: %EWL at 3, 6, and 12 months after surgery was 62.07 ± 26.56, 85.93 ± 27.92, and 106.65 ± 29.65, respectively, and %TWL was 22.67 ± 4.94, 32.10 ± 5.18, and 40.56 ± 7.89, respectively. Body weight and BMI 3 to 12 months after surgery were significantly lower than those before surgery (all P < 0.001). (3) Effect of treatment on metabolic disease: 3 to 12 months after surgery, fasting blood sugar, HbA1c, uric acid, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, LDL, and other indicators were significantly lower than those before surgery (all P < 0.05). Twelve months after surgery, the remission rates of diabetes, hyperuricemia, hypertension, hypertriglyceridemia, hypercholesterolemia, and high LDL were 100% (38/38), 65.2% (30/46), 62.2% (28/45), 94.3% (33/35), 100% (12/12), and 100% (12/12), respectively. (4) Changes in nutrient indicators: Compared with the preoperative nutrient levels, the hemoglobin and hematocrit levels were lower at 3 to 12 months after surgery, the total protein level was lower at 6 to 12 months after surgery, the albumin level was lower at 6 months after surgery, and the ferritin level was lower at 3 months after surgery. The differences were statistically significant (all P < 0.05). The incidence of anemia was 6.1% (4/66), hypoalbuminemia was 4.5% (3/66), and ferritin deficiency was 4.5% (3/66), all of which were improved or normalized through conservative treatment. Twelve months after surgery, 30 (45.5%) patients had vitamin A deficiency, 17 (25.8%) had vitamin E deficiency, 11 (16.7%) had folic acid deficiency, 2 had potassium deficiency (3.0%), 3 (4.5%) had calcium deficiency, 2 (3.0%) had magnesium deficiency, 9 (13.6%) had iron deficiency, and 16 (24.2%) had zinc deficiency. However, no relevant clinical symptoms occurred. Conclusions: SADI-S has a very significant effect on weight loss and alleviation of metabolic diseases. Nutrient deficiencies after SADI-S mainly involve vitamin A, vitamin E, zinc, and folic acid. The long-term efficacy and safety of SADI-S still need further follow-up observation.

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