Pharmacogenetics-guided study on the efficacy and safety of rivaroxaban in the treatment of isolated distal deep vein thrombosis in Han population, and the establishment of a clinical dose model

Start Date01 Jan 2025

Sponsor / Collaborator

Peking University People's Hospital

CTRI/2024/04/066001

/ CompletedPhase 3IIT

Technical success and outcomes using novel Banode-Mishra Technique (BMT) versus endovascular Rotational Thrombectomy device in acute iliofemoral vein thrombolysis - NIL

Start Date16 Jul 2024

Sponsor / Collaborator-

100 Clinical Results associated with Acute deep vein thrombosis of lower limb

100 Translational Medicine associated with Acute deep vein thrombosis of lower limb

0 Patents (Medical) associated with Acute deep vein thrombosis of lower limb

341

Literatures (Medical) associated with Acute deep vein thrombosis of lower limb

01 Jan 2025·Annals of Vascular Surgery

Comparative Study of Two Different Access Points, One Tibial Vein and the Popliteal Vein, for Catheter-Directed Thrombolysis in the Treatment of Acute Mixed Lower Extremity Deep Vein Thrombosis

Article

Author: Xu, Weiguo ; Luo, Hanlin ; Luo, Qinwen ; Chen, Xiaojie

BACKGROUNDAlthough the popliteal vein approach is commonly used for catheter-directed thrombolysis (CDT) treatment in patients with acute lower extremity deep vein thrombosis (DVT), CDT via a new access route, the posterior tibial vein, is also used and has demonstrated good results. However, this tibial approach has not been tested in large samples. In this article, we compare the early efficacy of CDT using the tibial and popliteal vein approaches for the treatment of acute mixed lower extremity DVT.METHODSIn this retrospective cohort study, 87 patients with acute mixed lower extremity DVT treated at the Department of Interventional Medicine of Zhuhai People's Hospital were enrolled; those with tibial vein access and popliteal vein access were included in the observation (n = 55) and control (n = 32) groups, respectively. The safety and efficacy of CDT via tibial vein access were investigated by collecting and comparing indicators such as venous patency, thrombus removal effect, thigh and calf circumference difference, swelling reduction rate of the affected limb, surgical complications, and postdischarge complication rate of the patients in the 2 groups.RESULTSThe postoperative thrombus clearance effect of the observation group was significantly better than that of the control group (P < 0.05), and the postoperative venous patency rate of the observation group was 83.2 ± 15.7%, which was higher than that of the control group (62.2 ± 38.2%) (P = 0.005). The swelling reduction rate of the lower extremity was 74.0 ± 33.8% in the observation group and 51.4 ± 30.0% in the control group, with a statistically significant difference (P = 0.002). However, there was no statistically significant difference (P > 0.05) in the rates of thigh swelling reduction, bleeding-related complications, or postoperative complications between the 2 groups of patients.CONCLUSIONSCDT via the tibial vein approach is safe, effective, and may be a better approach for CDT access, offering superior thrombus clearance, venous patency, and lower extremity swelling reduction postoperatively.

01 Dec 2024·Journal of Surgical Case Reports

Lessons learned from a case of phlegmasia cerulea dolens treated with thrombolysis and iliac vein stenting

Article

Author: Lee, Shaun Q W ; Chia, Adrian C K ; Yu, Junette ; Ng, Nick Z P

AbstractPhlegmasia cerulea dolens is a rare manifestation of massive deep vein thrombosis with threat to limb and life. A patient with a background of ovarian malignancy in remission and pelvic radiotherapy presented with left lower limb phlegmasia cerulea dolens as a result of extensive acute left lower limb deep vein thrombosis, extending from the popliteal vein to the inferior vena cava. While initial rapid thrombolysis and left iliac vein stenting were successful, she developed significant hemorrhagic complications from her right radial intra-arterial line with compartment syndrome requiring fasciotomy. She subsequently develops contralateral right lower limb deep vein thrombosis with phlegmasia cerulea dolens as a result of the cessation of anticoagulation and ‘jailing’ of the contralateral right iliac vein. Repeat thrombolysis with a lower dose of thrombolytics was performed, and contralateral iliac vein stenting in ‘kissing’ configuration was performed successfully. We discuss several lessons learned from this uncommon but important case.

01 Dec 2024·CardioVascular and Interventional Radiology

Early Thrombus Removal for Acute Lower Extremity Deep Vein Thrombosis: Update on Inclusion, Technical Aspects, and Postprocedural Management

Review

Author: Kee, Stephen ; Plotnik, Adam N ; Haber, Zachary

Acute lower extremity deep vein thrombosis (DVT) is a common disorder with significant associated morbidity, including pain and swelling, as well as the risk of pulmonary embolism (PE), recurrent venous thromboembolism (VTE) and chronic debilitating post-thrombotic syndrome (PTS). Anticoagulation is standard of care for DVT treatment. It assists in reducing thrombus progression and the occurrence of PE, but incomplete DVT resolution increases the risk of recurrent VTE, valvular insufficiency, and PTS. Endovascular DVT interventions, such as catheter-directed thrombolysis, pharmacomechanical thrombectomy, and large-bore mechanical thrombectomy offer an alternative therapeutic strategy for DVT management. This paper will discuss technical factors and current issues when performing lower extremity DVT interventions including patient selection, anticoagulation, choice of device for endovascular thrombus removal, adjunctive techniques, and venous stent management.Level of Evidence: No level of evidence for: review articles, basic science, laboratory investigations, and experimental study articles.

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