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Last update 08 May 2025

Mayaro Virus Infection

Last update 08 May 2025

Basic Info

Synonyms

Infection, Mayaro Virus, Mayaro Virus Infection, Mayaro Virus Infections

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Introduction-

Drugs associated with Mayaro Virus Infection

AdV-MAYV

Target-

Mechanism-

Active Org.

Oregon Health & Science University

Originator Org.

Oregon Health & Science University

Active Indication

Mayaro Virus Infection

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

scMAYV-E

Target-

Mechanism

Immunostimulants

Active Org.-

Originator Org.

The Wistar Institute

Active Indication-

Inactive Indication

Mayaro Virus Infection

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with Mayaro Virus Infection

100 Translational Medicine associated with Mayaro Virus Infection

0 Patents (Medical) associated with Mayaro Virus Infection

Literatures (Medical) associated with Mayaro Virus Infection

22 Apr 2025·The American Journal of Tropical Medicine and Hygiene

Transcriptomic Analysis of Mayaro Virus-Infected Human Macrophages: Effects on Inflammatory and Antiviral Response

Article

Author: Urcuqui-Inchima, Silvio ; Tamayo-Molina, Y. S. ; Hernández-Sarmiento, Lady Johana

Mayaro virus (MAYV) belongs to the Togaviridae family and is the etiologic agent of Mayaro fever, a disease in which inflammatory responses play a critical role in viral pathogenesis. Macrophages are targets of viral infection and key components of innate immunity and antiviral response. This study analyzed an RNA-sequencing (RNA-seq) dataset to gain insights into inflammatory and antiviral responses in monocyte-derived macrophages (MDMs) infected with the MAYV strain (Venezuelan 2010) at a multiplicity of infection (MOI) of 10. The RNA-seq results were validated by real-time quantitative polymerase chain reaction in MDMs infected with the MAYV strain from Brazil (MOI of 2). In addition, the replication capacity of MAYV and the resulting cell death in infected MDMs were assessed using plaque assays and flow cytometry. At 72 hours post-infection, transcriptomic analysis revealed that MAYV promotes a robust proinflammatory response by upregulating the expression of Toll-like receptors, RIG-I-like receptors, and the nuclear factor-κB complex. This strong inflammatory response was accompanied by a robust antiviral response dependent on type I/III interferon and interleukin-27. Both antiviral responses are mediated through the Janus kinase/signal transducer and activator of transcription signaling pathway, leading to the expression of interferon-stimulated genes. Moreover, MAYV-infected MDMs expressed markers of programmed cell death. These findings highlight the inflammatory response and antiviral activity of MDMs at a late stage in MAYV infection, suggesting a critical role of macrophages in MAYV pathogenesis.

31 Oct 2024·Eurosurveillance

A cluster of Mayaro virus infections in a film team returning from Suriname, February 2024

Article

Author: Feldt, Torsten ; Günther, Stephan ; Pfau, Stefanie ; Gabriel, Martin ; Müller-Stöver, Irmela ; Hornuss, Daniel ; Orth, Hans Martin ; Luedde, Tom ; Tappe, Dennis ; Holtfreter, Martha Charlotte ; Schmidt-Chanasit, Jonas

Mayaro virus is endemic to the tropical Americas, where the incidence is currently increasing. Like other viruses of the Semliki Forest virus serocomplex, such as Alphavirus chikungunya, symptomatic infections are typically characterised by an acute febrile disease followed by long-lasting arthralgia. Cases in travellers are rarely reported but may be underdiagnosed. We report on four people who diagnosed with Mayaro fever after working in remote areas of Suriname as members of a film team.

19 Oct 2024·Journal of Travel Medicine

Mayaro fever in Brazil from 2014 to 2024

Article

Author: Carvalho, Thialla Andrade ; Martins-Filho, Paulo Ricardo ; dos Santos, Cliomar Alves

The Mayaro virus, an arthropod-borne virus transmitted from mosquitoes to humans, is endemic in Central and South America. From 2014 to 2024, 314 Mayaro fever cases were registered in Brazil, with high-risk clusters in Goiás, Amazonas, and Pará, and an increasing trend of cases in the Amazon region.

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Mayaro Virus Infection

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