Down Syndrome

Day three of the world's largest startup and investment event unveiled transformational solutions across healthcare, space technology, and more at Dubai Harbour DUBAI, United Arab Emirates, Oct. 16, 2024 /PRNewswire/ -- Expand North Star 2024, the world's largest startup and investment event, continued its journey of innovation on its third day at Dubai Harbour. Attendees from around the world witnessed revolutionary advancements in Applied AI and Deep Tech, demonstrating how these technologies are disrupting industries and solving complex global challenges. Continue Reading Day 3 of Expand North Star showcases groundbreaking solutions in Health Tech, Applied AI, and Deep Tech Integrated with GITEX GLOBAL, Expand North Star runs until 16 October, providing a powerful platform for over 1,800 exhibiting startups and more than 1,200 investors managing assets exceeding USD $1 trillion. Applied AI and Deep Tech Innovations Redefine Healthcare and Space Innovation Day three was a showcase of next-generation solutions in robotics, AI, and deep tech, providing a glimpse into the future of these sectors. Cutting through the noise were innovative startups such as China's RoboCT with their innovative exoskeleton technology, launching the UGo Rehab Exoskeleton, specifically designed for patients with lower-limb dysfunction, spinal cord injury, strokes, or cerebral palsy. Dr. Tian Wang, Founder and CEO of RoboCT Group, stated, "UGo enhances the rehabilitation process and delivers an effective walking training solution by integrating advanced sensors, data analysis, and research, empowering patients to rehabilitate more effectively at home." On the digital health frontier, JADE introduced a platform tailored for neurodivergent children, including those with ADHD, down syndrome, and autism. The app's sophisticated tracking of eye movements, cognitive response times, and memory functions equips healthcare professionals and educators with precise data to create personalised care and learning strategies. Meanwhile, scanO, a pioneering Indian-born deep tech company, is leading the way in developing generative AI models for predicting disease progression. The company showcased its flagship product, scanO air—the world's first contactless AI-powered robotic system for oral health screening—revolutionizing early detection and diagnosis. In space technology sector, Triggers-Reports from Mauritius introduced Triggers-sat, a satellite platform that provides high-resolution imaging and 3D modeling to assist businesses and governments in areas such as natural resource management and climate risk disaster monitoring. Rising International Participation from Asia and Latin America As the global innovation hub, Expand North Star continues to see international participation rise, showcasing how regions and countries are pushing boundaries with novel solutions. Tatiana Riera, COO of ApexBrasil, highlighted Brazil's expanding presence at Expand North Star: "From just 20 startups in 2019, we have expanded to 45 startups this year, along with four innovation hubs. Brazil is a great hub for fintech because of the diversity in social levels, so most of our unicorns come from fintech. We also focus a lot on Deep Tech, AI, and climate tech solutions since we have six biomes and need to take care of them. We have a company that uses natural foam to build soundproof material for construction and another company building silent tractors that run on renewable energy." Similarly, Singapore's SGTech made a noteworthy debut at Expand North Star, emphasizing the importance of cross-border collaboration in driving tech-driven solutions forward. Alex Ng, Exco Member, SGTech said: "Singapore's innovative startups are making a significant impact at Expand North Star 2024, with six outstanding companies exhibiting under the Singapore Pavilion. These companies showcase cutting-edge technologies across various sectors, including digital twins, industrial AI and biotech, with the event serving as a groundbreaking global launchpad for startups to foster valuable networking with investors." Africa's Path to Economic Growth With global participation continuing to flourish, the spotlight also turned towards Africa, where burgeoning tech ecosystems are paving the way for a new wave of entrepreneurs and innovators. H.E. Savannah Maziya, Minister, Ministry of Information, Communications & Technology, Eswatini, alongside other thought leaders, emphasised the importance of structured development to tackle unique market challenges and unlock Africa's economic potential. Celina Lee, CEO & Co-Founder, Zindi, South Africa, highlighted the trend of talent returning to Africa to start companies and create ecosystems that foster innovation and attract global corporations like Microsoft to set up labs in Ghana and Nairobi. Speaking on the challenges facing Africa, Olatunbosun Alake, Honorable Commissioner, Ministry of Innovation, Science and Technology, Lagos State Government, Nigeria, said, "The greatest challenge in Africa is education. In Nigeria, if you look at the most educated parts, they show economic value, whereas in the north, where education levels are not as high, economic productivity is lower. There needs to be an African Renaissance of education funding across the board because if you drive education, educate, and enlighten people, people will change the environment." Across its four-day span, Expand North Star continues to shed light on the future of industries through defining events such as GITEX Impact, Fintech Surge, Future Blockchain Summit, and Marketing Mania. These events underscore how emerging technologies are transforming the way we live and are also playing a pivotal role in reshaping the future. Follow Expand North Star on Social Media: Facebook | X | Instagram | LinkedIn Hashtag: #ExpandNorthStar About Dubai World Trade Centre (DWTC): A global business facilitator since 1979, Dubai World Trade Centre (DWTC) is home to the region's leading purpose-built convention and exhibition centre. DWTC provides a platform for connecting people, products, innovation and ideas from around the world through a dynamic calendar of international trade exhibitions and its own roster of sector leading mega events. As a designated free zone, complemented by award-winning commercial real estate, DWTC plays an integral role in Dubai and the region's growth story. Since its inauguration, DWTC has hosted over 6,000 events, with an estimated economic output of AED 248 billion, attracting over 38 million business visitors to Dubai. Photo: SOURCE Expand North Star WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Funded by the Advanced Research Projects Agency for Health, the RADIANT project has the potential to establish a model for control data in clinical trials for difficult-to-treat diseases PHILADELPHIA, Oct. 9, 2024 /PRNewswire/ -- A multi-institutional program led by researchers at the Center for Data Driven Discovery in Biomedicine (D3B) at Children's Hospital of Philadelphia (CHOP) has received up to $10 million Advanced Research Projects Agency for Health (APRA-H) Mission Office Innovative Solutions Openings award to research, validate and implement a new model for sharing and integrating data at a national level. This new model is designed to empower research on cancer and other rare diseases in real time, accelerating discoveries and transforming the quality of care for children affected by disease. The project – Real-time Analysis and Discovery in Integrated And Networked Technologies (RADIANT) – builds upon years of pediatric research at D3B aimed at innovating health care and processing millions of points of data at a larger scale to discover underlying causes of complex cancers and diseases and making those findings rapidly available to researchers and clinicians across the country and the world. The RADIANT project is the first ARPA-H-funded project at CHOP. "In the setting of pediatric brain tumors and other rare diseases, we often do not have a curative standard of care," said Adam Resnick, PhD, research scientist in the Department of Biomedical and Health Informatics at CHOP and Co-Executive Director of D3B. "As a result, most patients actively participate in a research care model that includes participation in research protocols and clinical trials. Our vision for RADIANT is that clinicians and researchers are able to access real-time data about all patients who might share similarities across different data modalities with any one patient, harnessing cloud-based tools and computation to advance real-time decision making and diagnostics and expedite a patient's access to potential precision medicines and personalized treatments or relevant clinical trials." Expanding on platform tools developed as part of the Gabriella Miller Kids First Data Resource Center and the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Data Hub, the RADIANT project aims to advance new technologies and tools as part of a network architecture that advances the real-time integration of data from a participating patient's electronic health records with genomic and imaging data. With CHOP as the coordination center of the initiative, the goal is to scale linkages across a network of hospitals throughout the nation, sharing critical data and information as well as providing resources for interpreting that data. Researchers at CHOP's D3B will be partnering with other institutions across more than 35 hospitals comprising the Children's Brain Tumor Network (CBTN) and the Pediatric Neuro-Oncology Consortium (PNOC) to develop, deploy, and pilot this groundbreaking resource that advances the interoperability and use of data through platform-enabled standardization and emerging technologies that harness powerful new tools and computational approaches. "D3B has been able to consistently accelerate discoveries in pediatric cancer, thanks to our focus on big data and the collaborative researchers around the world who utilize our platforms," said Phillip "Jay" Storm, MD, Chief of the Division of Neurosurgery and Co-Director of the Neuroscience Center at CHOP and Co-Executive Director of D3B.data. "This award takes the advancements we've made in the field of pediatric brain tumors and expands them in exciting new directions," "A core tenet of our mission has always been the marriage of research and clinical work, and when fully realized, the work accomplished through this award will transform how bench-to-bedside models of care can improve patients' lives." While the initial goals of the RADIANT project will be to use these tools to enhance the precision-based care patients receive while under treatment by their doctor, advancing the research care framework will ultimately inform new models for clinical trial coordination and enhance patient access to care through such trials. "We need to standardize and advance multiple data workflows across institutions in ways that create a unified, real-time view of a patient, combining clinical data workflows with research data from observational and clinical trials," said Sabine Mueller MD, PhD, co-executive chair of CBTN and co-leader of PNOC. "Many pediatric brain tumor patients have no curative standard of care, it's only through advancing new models of care empowered by these technologies that as clinicians we'll be able to enhance options for our patients and their participation in clinical trials." In addition to partnering institutions across CBTN and PNOC, the RADIANT initiative brings together investigators from the Centre Hospitalier Universitaire Sainte-Justine and the HealthShare Exchange (HSX) as well as technology partners including Amazon Web Services, MuleSoft (from Salesforce), Kno2, Peyk, and Flywheel. Founded in 2022, the ARPA-H is an agency within the Department of Health and Human Services with a mission of accelerating better health outcomes for everyone by supporting the development of high-impact solutions to society's most challenging health problems. The agency aims to ensure access to solutions regardless of demographics or geography, leveraging diverse perspectives for sustained equity across their policy, practices and programs. This research is supported by ARPA-H under agreement number 140D042490007. About Children's Hospital of Philadelphia: A non-profit, charitable organization, Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals, and pioneering major research initiatives, the hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country. The institution has a well-established history of providing advanced pediatric care close to home through its CHOP Care Network, which includes more than 50 primary care practices, specialty care and surgical centers, urgent care centers, and community hospital alliances throughout Pennsylvania and New Jersey, as well as the Middleman Family Pavilion and its dedicated pediatric emergency department in King of Prussia. In addition, its unique family-centered care and public service programs have brought Children's Hospital of Philadelphia recognition as a leading advocate for children and adolescents. For more information, visit Contact: Ben Leach Children's Hospital of Philadelphia (609)634-7906 [email protected] SOURCE Children's Hospital of Philadelphia WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Inspire® Procedure is first FDA-approved sleep apnea treatment for children with Down syndrome who are unable to use CPAP therapy. LONG BEACH, Calif., Aug. 28, 2024 /PRNewswire/ -- MemorialCare Miller Children's & Women's Hospital Long Beach completed Los Angeles' first two pediatric Inspire® procedures helping children with Down syndrome suffering from obstructive sleep apnea (OSA). Inspire is an FDA-approved obstructive sleep apnea device that can help treat and prevent sleep apnea for Down syndrome children who cannot use Continuous Positive Airway Pressure (CPAP) therapy and are not effectively treated by adenotonsillectomy (surgical removal of the tonsils and adenoids). "Over 60% of children with Down syndrome are affected by obstructive sleep apnea since they tend to have smaller breathing pathways, lower muscle tone, and enlarged adenoids, tonsils and tongues obstructing their airway," says Gary Feldman, M.D., medical director, Pediatric Sleep Program at Stramski Children's Developmental Center, MemorialCare Miller Children's & Women's Hospital Long Beach. "Left untreated, obstructive sleep apnea will significantly impact children with Down syndrome, often affecting their language, behavior, and ability to do well in school." OSA occurs when the airway collapses during sleep. This prevents the child from taking a good breath while sleeping, leading to a drop in the amount of oxygen in the blood. The brain senses this and will wake the child up long enough to take a good breath, after which the child returns to sleep. This cycle of not breathing well, then briefly waking to get a few good breaths, can continue throughout the night. In severe cases this can lead to high blood pressure and have negative effects on the heart, but in all cases, the child is not getting a good night's rest. Since many of these patients have enlarged tonsils and adenoids, surgery to remove the tonsils and adenoids is the traditional first-line treatment option for opening the airway, but studies have shown less than 30% of children with Down syndrome benefit from the procedure. Additionally, CPAP therapy is difficult for this pediatric population because children with Down syndrome are more likely to have sensory difficulties, which can make wearing a CPAP mask extremely difficult as a long-term solution. "The Inspire system is implanted under the skin of the neck and chest during a short surgical procedure," says Namrata Varma, D.O., pediatric otolaryngologist, MemorialCare Miller Children's & Women's Hospital Long Beach. "Inspire works inside the body with a patient's natural breathing process, using mild stimulation to open the airway during sleep, allowing oxygen to flow naturally. The system is activated by a small handheld remote to turn Inspire on before bed and off when they wake up." During sleep, your tongue relaxes. For people with OSA, your tongue relaxes into a position that blocks your airway. The Inspire implant works comfortably inside your body to sense when you take a breath. Then, it gently moves your tongue forward to keep your airway open, helping you breathe regularly and sleep soundly. The device works automatically throughout the night, and the level of stimulation can be adjusted through the handheld remote as needed to ensure comfort and effectiveness. Because Inspire is a simple, low-maintenance therapy that works without the use of a mask or hose, children are able to sleep more peacefully at night, allowing for more restful sleep. Caregivers report their children with Down syndrome have less daily tiredness and show increased alertness and energy after consistent use of Inspire. "We are so excited to offer this groundbreaking therapy to our pediatric patients with Down syndrome," says Ayal Willner, M.D., pediatric otolaryngologist, MemorialCare Miller Children's & Women's Hospital Long Beach. "The ability to provide a treatment that significantly improves sleep quality and overall health for these children is incredibly rewarding." The criteria for the pediatric Down syndrome population to be considered for Inspire include being 13 years of age or older, having a diagnosis of OSA, and having either an inability to tolerate or having failed CPAP. The safety and efficacy of Inspire was evaluated during the STAR clinical trial. Five-year STAR trial outcomes show patients using Inspire experience significant reductions in sleep apnea events and significant improvements in quality-of-life measures. There have been over 150 peer-reviewed publications on Inspire showing results consistent with those seen in the STAR trial. About MemorialCare Miller Children's & Women's Hospital Long Beach: MemorialCare Miller Children's & Women's Hospital Long Beach is a member of MemorialCare, a not-for-profit, integrated health care delivery System. Miller Children's & Women's provides specialized pediatric care for children and young adults, as well as maternity care for expectant mothers. Only five percent of hospitals are children's hospitals, making them unique not only to children's health care needs in the community, but across the region. Miller Children's & Women's is one of only eight free-standing children's hospitals in California — treating more than 14,000 children each year — and has become a regional pediatric destination for more than 65,000 children, who need specialized care in outpatient specialty and satellite centers. With maternal-fetal medicine specialists and neonatologists available 24/7, Miller Children's & Women's cares for women with high-risk pregnancies and premature infants under one roof. Learn more millerchildrens.org. About Inspire Medical Systems Inspire® is a medical technology company focused on the development and commercialization of innovative, minimally invasive solutions for patients with obstructive sleep apnea. Inspire's proprietary Inspire therapy is the first and only FDA-approved neurostimulation technology that provides a safe and effective treatment for moderate to severe obstructive sleep apnea. For additional information about Inspire, please visit . SOURCE Miller Children’s & Women’s Hospital Long Beach