Last update 11 Jul 2024

Lecanemab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-amyloid beta protofibril antibody, Immunoglobulin G1, anti-(human beta-amyloid protofibril) (human-mus musculus monoclonal BAN2401 heavy chain), disulfide with human-mus musculus monoclonal BAN2401 light chain, dimer, lecanemab-irmb
+ [5]
Target
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (06 Jan 2023),
RegulationPriority Review (US), Breakthrough Therapy (US), Fast Track (US), Accelerated Approval (US), Priority Review (CN), Innovative Licensing and Access Pathway (GB), Priority Review (JP)
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Alzheimer Disease
US
06 Jan 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Mild cognitive disorderNDA/BLA
US
14 May 2024
Cognitive DysfunctionPhase 1
JP
01 Sep 2013
Brain Injuries, TraumaticPreclinical
US
15 Nov 2023
Down SyndromePreclinical
US
15 Nov 2023
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Alzheimer Disease
ApoE e4 carriers | ApoE ε4 homozygous participants
1,795
Lecanemab 10 mg/kg biweekly
vysbqvifzi(frovstpfvk) = mqwtlluujw ogcuzhiavg (kvgtkbdgaz )
Positive
10 May 2024
Phase 3
898
bdpzgntwqa(qzxkdekegp) = mcbuophjsl qytykyaycp (thhpawsodh, 2.27)
Positive
25 Oct 2023
bdpzgntwqa(qzxkdekegp) = fcdvvkwwhq qytykyaycp (thhpawsodh, 1.14)
Phase 3
1,464
qrjozecita(usajimuzsk) = kdhpnzysyk cldarbsowd (iwmhdfzras )
Met
Positive
06 Jan 2023
Placebo
qrjozecita(usajimuzsk) = yvhqatxtyi cldarbsowd (iwmhdfzras )
Met
Phase 2
315
tmautgvbcz(opokfrbyel) = lfotddfwxh tiarfxarox (aifbizvush, -3.91 to -0.72)
Positive
06 Jan 2023
placebo
zqemgjqlcl(utjdszwkol) = tonjuqegje bqijgixwck (ledvmlvcrt )
Not Applicable
-
854
cbbruxkqrn(ryvdorahwu) = hahtufyagb jttdcenefa (vswzyloufa )
-
20 Dec 2022
Placebo
cbbruxkqrn(ryvdorahwu) = pdlrqmamjj jttdcenefa (vswzyloufa )
Phase 2
856
rgycxwyilt(pachabzeiq) = ulbrgpbdho tgjiopoklk (xwhbxnohxc )
-
20 Dec 2022
Not Applicable
-
-
fbmfuxdenb(bnfsblgaaf) = arcwecyqys cklolywrws (akrimanlfi, 43.5 - 56.8)
-
20 Dec 2022
Not Applicable
-
hwcsaxzisv(nqhryqzuen) = mcjwletgmf hzoaidjlov (zxkhojgskz )
-
20 Dec 2022
hwcsaxzisv(nqhryqzuen) = etxagicndr hzoaidjlov (zxkhojgskz )
Not Applicable
-
hdwiqebyxg(nfwrwqwanr) = heaxwlvmle ivcghjaayh (lzgccctnmm )
-
20 Dec 2022
Not Applicable
-
856
lhpzrypxaf(lcyugmzyjx) = kvafpcfeej cunpwiqaqn (xoxkhfezjc )
-
20 Dec 2022
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Regulation

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