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Last update 23 Jan 2025

Alcohol Withdrawal Delirium

Last update 23 Jan 2025

Basic Info

Synonyms

ALCOHOL WITHDRAWAL DELIRIUM TREMENS, ALCOHOLIC DELIRIUM, Alcohol Withdrawal Associated Autonomic Hyperactivity

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Introduction

An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)

Drugs associated with Alcohol Withdrawal Delirium

Paraldehyde

Target-

Mechanism-

Active Org.

Phebra Pty Ltd.

Originator Org.-

Active Indication

Agitation [+6]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

Australia

First Approval Date31 Aug 2009

Clinical Trials associated with Alcohol Withdrawal Delirium

DRKS00035499

/ SuspendedNot Applicable

Evaluation of a specialist geriatric assessment in oral and maxillofacial surgery to identify patients at risk of postoperative delirium - a prospective clinical study

Start Date01 Jan 2025

Sponsor / Collaborator-

DRKS00035091

/ RecruitingNot ApplicableIIT

Feasibility, Acceptance and Preliminary Efficacy of the Multimodal AKTIVER Heart Delirium Prevention Program in Patients Following Cardiac Surgery: Randomized Controlled PREVENT POstoperative Delirium (PREVENT-POD) Study - PREVENT-POD

Start Date15 Nov 2024

Sponsor / Collaborator-

DRKS00032529

/ RecruitingNot Applicable

Diagnosing delirium in geriatric patients by asking relativesthe Single Question in Delirium (SQiD) - Diagnosing delirium by Single Question in Delirium (SQiD)

Start Date09 Oct 2024

Sponsor / Collaborator-

100 Clinical Results associated with Alcohol Withdrawal Delirium

100 Translational Medicine associated with Alcohol Withdrawal Delirium

0 Patents (Medical) associated with Alcohol Withdrawal Delirium

2,235

Literatures (Medical) associated with Alcohol Withdrawal Delirium

01 Mar 2025·Sleep and Breathing

The relationship between fatigue, sleep quality, and sleep deprivation

Article

Author: Özcebe, Lütfiye Hilal ; Ayas, Fahriye Yonca

BACKGROUNDFatigue, sleep disorders, and daytime sleepiness are interconnected, posing significant risks to occupational health and workplace safety. However, the literature on their relationships remains fragmented, with notable gaps, particularly concerning working populations. This descriptive cross-sectional study aimed to evaluate sleep quality (SQ), daily sleep time in hours (DST), daytime sleepiness, fatigue levels among employees in an automotive workplace, and their interrelationships.METHODSThis study assessed fatigue, DST, SQ, and daytime sleepiness (DTS) among employees aged 21-51 years working under the same conditions. Data were collected using questionnaires and two validated scales: the Check Individual Strength Scale (CIS) for fatigue and the Epworth Sleepiness Scale (ESS) for excessive daytime sleepiness.RESULTSNone of the Check Individual Strength Scale (CIS), or SQ points, mean values or DST hours values significantly differ due to any sociodemographic independent variables. Epworth Sleepiness Scale (ESS) points mean values differ significantly due to BMI values. However, statistically significant relationships were identified among CIS, ESS, SQ points, and DST hours. Additionally, a positive correlation was observed between ESS and CIS scores. These findings suggest reciprocal effects among fatigue, SQ, DST, and daytime sleepiness.CONCLUSIONWhile sleep problems cause fatigue also chronic fatigue syndrome may be the reason of worse SQ. Further research is necessary to emphasize the importance of addressing the interplay between fatigue, excessive daytime sleepiness, SQ, and DST in hours to improve workplace safety and employee well-being.

01 Jan 2025·Progress in Neuro-Psychopharmacology and Biological Psychiatry

Plasma neurofilament light chain levels are associated with delirium tremens in patients with alcohol use disorder

Article

Author: Liu, Tung-Hsia ; Meng, Shih-Chun ; Chang, Hu-Ming ; Liu, Yu-Li ; Kuo, Hsiang-Wei ; Huang, Ming-Chyi ; Hou, Yu-Chi ; Bavato, Francesco

Delirium tremens (DT) is the most severe and life-threatening manifestation of alcohol withdrawal. Prompt identification and treatment are crucial in the clinical management of DT, but laboratory markers in this context are still lacking. Neurofilament light chain (NfL) has been proposed as a novel blood marker of neuroaxonal pathology. Therefore, we investigated the association between plasma NfL levels on admission and the occurrence of DT in patients with alcohol use disorder (AUD). NfL levels were measured on admission in 224 patients with AUD undergoing alcohol withdrawal treatment and in 116 healthy individuals. We monitored patients with AUD during the following 2 weeks of hospitalization and categorized them according to the prospective occurrence of DT (n = 25) or not (n = 199). Plasma NfL levels at admission were highest in patients who later developed DT, compared to AUD patients without DT, and healthy individuals (63.1 ± 47.2, 24.0 ± 22.4, 11.8 ± 6.1 pg/mL, respectively, p < 0.001). Receiver operating characteristic analysis revealed that a cut-off NfL level of 27.2 pg/mL could discriminate AUD patients who later developed DT (sensitivity: 80.0 %; specificity: 72.4 %; area under the curve: 0.84, p < 0.001), with an odds ratio of 9.43 (95 % CI 3.26-27.32; p < 0.001) for the risk of developing DT. Our findings suggest that NfL levels at admission may predict DT occurrence in patients with AUD and implicate neuroaxonal pathology in the pathophysiology of DT. Further research is needed to validate these findings and to explore the underlying neurobiological mechanisms.

01 Jan 2025·Fortschritte der Neurologie · Psychiatrie

Systematische Übersichtsarbeit Antipsychotische Behandlung des Alkoholentzugssyndroms: Fokus Delirium Tremens

Review

Author: Kamp, Daniel ; Kojda, Georg ; Faustmann, Timo Jendrik ; Schilbach, Leonhard ; Paschali, Myrella

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Alcohol Withdrawal Delirium

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