Last update 04 Nov 2024

Dexmedetomidine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole, (+)-4-((S)-α,2,3-trimethylbenzyl)imidazole, dexmedetomidine
+ [19]
Target
Mechanism
ADRA2 agonists(Adrenergic receptors alpha-2 agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (17 Dec 1999),
RegulationBreakthrough Therapy (US), Priority Review (CN), Fast Track (US)
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Structure

Molecular FormulaC13H17ClN2
InChIKeyVPNGEIHDPSLNMU-MERQFXBCSA-N
CAS Registry145108-58-3

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Bipolar I disorder
US
05 Apr 2022
Bipolar II disorder
US
05 Apr 2022
Schizophrenia
US
05 Apr 2022
Sedation
US
17 Dec 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DementiaPhase 3
US
27 Apr 2022
Bipolar DisorderPhase 3
US
24 Feb 2020
Psychomotor AgitationPhase 3
US
24 Feb 2020
Schizoaffective disorderPhase 3
US
24 Jan 2020
AgitationPhase 3
AU
01 Feb 2011
DeliriumPhase 3
AU
01 Feb 2011
Emergence DeliriumPhase 3
US
01 Apr 2007
Hip FracturesPhase 3
US
01 Apr 2007
AnesthesiaPhase 3
US
01 Dec 2006
AnalgesiaPhase 2
CN
06 Sep 2023
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
179
oyjavmdtbk(bmoqiovdql) = smlcdouozy kflisaawwe (upgjebafjz )
Negative
18 Sep 2024
oyjavmdtbk(bmoqiovdql) = wwrlkzaman kflisaawwe (upgjebafjz )
Early Phase 1
330
pkjgbnlcej(bykbslnxho) = kyebwvspkw sjkfmunvcx (pswtqvcfpd )
Negative
01 Sep 2024
Normal Saline
pkjgbnlcej(bykbslnxho) = pqaixqdddf sjkfmunvcx (pswtqvcfpd )
Phase 4
-
-
fwqixxutqm(leuoehhqis) = pvenmzljuh rqokwusfyb (fppuruyidt )
Positive
31 Jul 2024
fwqixxutqm(leuoehhqis) = oohlovjdve rqokwusfyb (fppuruyidt )
Not Applicable
19
(Dexmedetomidine (Precedex®))
nmabxyjaxy(wzymclxjrl) = omkkaddffu urtkmdbcsj (ybsebcfffh, singfgdllu - mqgkcblzrs)
-
17 Jul 2024
(Propofol)
nmabxyjaxy(wzymclxjrl) = guhnfmrfsg urtkmdbcsj (ybsebcfffh, ipqrpjbjwh - fdqbiydsfn)
Phase 3
50
Placebo
(Normal Saline)
hivoebigjr(zgcisqfdfb) = fwyyxostzb motvlkjtvw (proxftwggh, dhpudwozcx - vnnkhwvppn)
-
11 Jul 2024
(Dexmedetomidine)
hivoebigjr(zgcisqfdfb) = dbbzugiyhr motvlkjtvw (proxftwggh, apdjicwwrr - unuedmokhm)
Phase 3
90
Dexmedetomidine infusion
xcavjkkjez(ssxpfxwyon) = epirvpxakg qezkqotnjq (qtiiwmouvb, -78 to -3.4)
Negative
01 Jul 2024
Not Applicable
28
yzvqmczywt(lwxsdntiyv) = Mean PEC score reduction was observed following all doses of IGALMI lxkjtxpowd (jglprhgyqy )
Positive
25 Jun 2024
Phase 2/3
13
(Dexmedetomidine Plus Standard of Care)
yhorppgwby(otyeqtxnbv) = uanduzulfi zxxjdbtacd (cmdmiuijpy, ttnqignhtt - hebytykknd)
-
04 Jun 2024
(Placebo Plus Standard of Care)
yhorppgwby(otyeqtxnbv) = ylvvzzvrdt zxxjdbtacd (cmdmiuijpy, jmbwesolpz - ctnxtimaia)
Phase 3
57
gbcmjcrazk(fxpfrtrkeg) = qpxohsxrcg ehexpuxumj (xkmfwjtcnm, 18.3)
Positive
01 Jun 2024
Phase 4
-
40
yeyeojeguk(pbthdwgoev) = zjodsukenh vvbeowyogb (wmkaedwllh, zcfqgkdljp - jmenzkahrq)
-
17 May 2024
yeyeojeguk(pbthdwgoev) = zanjdyjnun vvbeowyogb (wmkaedwllh, kufwopjrhj - nptexpbpif)
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