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Last update 08 May 2025

Glaucoma-Related Pigment Dispersion Syndrome

Last update 08 May 2025

Basic Info

Synonyms

GLAUCOMA, PIGMENT-DISPERSION TYPE, GLAUCOMA-RELATED PIGMENT DISPERSION SYNDROME, GPDS1

+ [16]

Introduction

Condition where iris pigment is released into the anterior chamber and deposited in the trabecular meshwork, due to a procedure or device implantation.

Drugs associated with Glaucoma-Related Pigment Dispersion Syndrome

PER-001

Target

endothelin receptor

Mechanism

endothelin receptor antagonists

Active Org.

Perfuse Therapeutics, Inc.

Originator Org.

Perfuse Therapeutics, Inc.

Active Indication

Nonproliferative diabetic retinopathy [+4]

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Glaucoma-Related Pigment Dispersion Syndrome

NCT06682962

/ RecruitingNot Applicable

Transcorneal Electrical Stimulation for the Treatment of Visual Field Defects in Patients With Open-Angle Glaucoma - a Monocentric, Randomized, Double-Masked, Sham-Controlled Pilot Study

Glaucoma is a progressive optic neuropathy with retinal ganglion cell loss which leads to visual field loss. Open-angle glaucoma is the most common form of glaucoma.
The aim of this pilot study is to evaluate the safety and effectiveness of the treatment of visual field defects using transcorneal electrical stimulation (TES) with the OkuStim 2 System in patients with primary open-angle glaucoma, pseudoexfoliation glaucoma, pigment dispersion glaucoma or normal tension glaucoma.

Start Date02 Apr 2025

Sponsor / Collaborator

Okuvision GmbH

DRKS00034870

/ RecruitingNot ApplicableIIT

Evaluation Of Change in Corneal Biomechanics Following Non-Penetrating Deep Sclerectomy compared to Trabeculectomy or Paul-Implant in Glaucoma Patients: Insights From Ocular Response Analyzer (ORA) Measurements - Biomechanics after glaucoma surgery

Start Date07 Oct 2024

Sponsor / Collaborator-

DRKS00031874

/ RecruitingNot ApplicableIIT

Observational study/ pilot study of cyclophotocoagulation in advanced glaucoma

Start Date17 Jul 2023

Sponsor / Collaborator-

100 Clinical Results associated with Glaucoma-Related Pigment Dispersion Syndrome

100 Translational Medicine associated with Glaucoma-Related Pigment Dispersion Syndrome

0 Patents (Medical) associated with Glaucoma-Related Pigment Dispersion Syndrome

389

Literatures (Medical) associated with Glaucoma-Related Pigment Dispersion Syndrome

01 May 2025·European Journal of Ophthalmology

A pigment dispersion syndrome case with concave iris and ocular hypertension managed through a phakic ICL implantation

Article

Author: Alfonso-Bartolozzi, Belén ; Rodriguez-Una, Ignacio ; Alfonso, Jose F. ; Madrid-Costa, David ; Fernández-Vega-Cueto, Luis ; Fernández-Vega-Cueto, Andrés ; Martínez-Alberquilla, Irene

IntroductionA concave iris configuration is a characteristic feature of pigment dispersion syndrome (PDS). Therapeutic strategies to modify this configuration may be considered as first-line options for the treatment of ocular hypertension in PDS patients.Case descriptionA 37-year-old male patient with myopic anisometropia presented bilateral PDS with concave iris, Krukenberg's spindle and iris transillumination defect in both eyes. The intraocular pressure (IOP) was 27 mmHg in both eyes. Optic nerve and visual field parameters were normal. The right eye was treated with a neodymium:YAG LPI. In the left eye, an implantable collamer lens (ICL) V4c model implantation for myopia correction was performed. Six-months postoperatively, both eyes evidenced an anteriorization of the iris, the morphology of the concave iris improved with the ICL V4c in place, becaming flattener in left eye. The IOP was 18 mmHg without treatment.ConclusionThis case report reinforces the idea that in myopic patients with a concave iris, the refractive correction approach through ICL V4c implantation might also improve the iris configuration, similarly to laser peripheral iridotomy (LPI). Therefore, in this specific patient profile, this surgical procedure might be considered as a prophylactic treatment alternative to prevent the complications associated with this iris configuration, although its invasive nature should be taken into consideration.

01 Mar 2025·Archivos de la Sociedad Española de Oftalmología (English Edition)

Bilateral acute iris transilumination: Description of two cases

Article

Author: Rodriguez Gómez, A M ; Palacio Aguirre, J M ; Naranjo Salazar, S ; Restrepo Velásquez, S

Bilateral Acute Iris Transillumination (BAIT) syndrome is characterized by a severe pigment dispersion with secondary iris atrophy and increased intraocular pressure (IOP). We report two cases of female patients aged 31 and 37 years respectively with a diagnosis of BAIT syndrome who required management for ocular hypertension secondary to pigment dispersion syndrome including medical therapy and surgical management in one case. It is important to consider BAIT syndrome as a differential diagnosis in pigment dispersion syndrome or pseudo-uveitis cases because of the need for timely management to prevent visual loss secondary to glaucomatous optic neuropathy.

01 Mar 2025·Current Opinion in Ophthalmology

Overlap syndrome: a case series and literature review of concurrent pigment dispersion and pseudoexfoliation syndromes

Review

Author: Soundararajan, Srinath ; Shah, Pooja ; Fleischman, David

Purpose of reviewThe purpose of this review is to present two cases of overlap syndrome, or concurrent pigment dispersion syndrome and pseudoexfoliation syndrome. The summary of existing literature highlights the importance of accurate diagnosis and potential treatment options of overlap syndrome.Recent findingsThe cases describe two patients with overlap syndrome and resulting progressive glaucoma. The condition tends to present after age 50 years old, with presence of both pseudoexfoliative material and pigment dispersion signs. The pigment dispersion syndrome may be quiescent at the time of pseudoexfoliation onset and may have gone undiagnosed. This form of glaucoma poses challenges in controlling intraocular pressure and may progress rapidly, often requiring surgical intervention.SummaryThis paper reviews the common examination findings of pigment dispersion syndrome and pseudoexfoliation, which may aid clinicians in the diagnosis of the rare condition, overlap syndrome. The connection between the two conditions remains unclear, though studies of possible genetic associations are underway. The two-hit theory, or initial damage to the trabecular meshwork increasing susceptibility to future damage, is plausible given the severe nature of the condition. Though definitive conclusions regarding treatment strategies and outcomes of overlap syndrome are lacking, increased awareness, diagnosis, and study of the condition may help guide the management of overlap syndrome.

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