Last update 01 Nov 2024

Balantidiasis

Last update 01 Nov 2024

Basic Info

Synonyms

B. coli Infection, B. coli Infections, BALANTIDIASIS

+ [32]

Introduction

Infection by parasites of the genus BALANTIDIUM. The presence of Balantidium in the LARGE INTESTINE leads to DIARRHEA; DYSENTERY; and occasionally ULCER.

Drugs associated with Balantidiasis

Metronidazole Benzoate

Target-

Mechanism

DNA synthesis inhibitors

Active Org.-

Originator Org.-

Active Indication

Amebiasis [+6]

Inactive Indication

Gastrointestinal motility disorder

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date26 Nov 2002

Clinical Trials associated with Balantidiasis

CTR20231650 / CompletedNot Applicable

甲硝唑片健康人体生物等效性研究

[Translation] Study on the bioequivalence of metronidazole tablets in healthy volunteers

主要试验目的：在中国健康受试者中评价单次空腹和单次餐后服用安徽宏业药业有限公司生产的甲硝唑片0.2g（规格：0.2g/片；受试制剂）和西班牙sanofi-aventis Ireland Ltd., T/A SANOFL生产的的甲硝唑片200mg（规格：200mg/片；参比制剂）的生物等效性；次要试验目的：观察受试制剂和参比制剂在健康受试者中的安全性。

[Translation]

Primary study objective: To evaluate the bioequivalence of single fasting and single postprandial administration of metronidazole tablets 0.2g (specification: 0.2g/tablet; test preparation) produced by Anhui Hongye Pharmaceutical Co., Ltd. and metronidazole tablets 200mg (specification: 200mg/tablet; reference preparation) produced by sanofi-aventis Ireland Ltd., T/A SANOFL, Spain in healthy Chinese subjects; Secondary study objective: To observe the safety of the test preparation and the reference preparation in healthy subjects.

Start Date09 Jul 2023

Sponsor / Collaborator

Anhui Hongye Pharmaceutical Co. Ltd.

CTR20220468 / Active, not recruitingNot Applicable

甲硝唑片在健康受试者中随机、开放、两制剂、单次给药、两周期、双交叉空腹/餐后生物等效性试验

[Translation] A randomized, open-label, two-formulation, single-dose, two-period, double-crossover fasting/fed bioequivalence study of metronidazole tablets in healthy subjects

主要目的：以药代动力学参数作为主要终点评价指标，比较口服受试制剂甲硝唑片（生产厂家：江西新赣江药业股份有限公司）与参比制剂甲硝唑片（持证商：Sanofi，商品名：Flagyl®）在健康受试者体内空腹/餐后状态下的药代动力学行为，评价两种制剂在空腹/餐后条件下是否具有生物等效性。次要目的：观察受试制剂甲硝唑片和参比制剂甲硝唑片在健康受试者中的安全性。

[Translation]

Main purpose: To compare the pharmacokinetic behavior of the oral test preparation metronidazole tablets (manufacturer: Jiangxi Xin Ganjiang Pharmaceutical Co., Ltd.) and the reference preparation metronidazole tablets (certificate holder: Sanofi, trade name: Flagyl®) in healthy subjects under fasting/postprandial conditions, using pharmacokinetic parameters as the primary endpoint evaluation indicators, and to evaluate whether the two preparations are bioequivalent under fasting/postprandial conditions. Secondary purpose: To observe the safety of the test preparation metronidazole tablets and the reference preparation metronidazole tablets in healthy subjects.

Start Date21 Feb 2022

Sponsor / Collaborator

Jiangxi New Ganjiang Pharmaceutical Co., Ltd.

CTR20210515 / CompletedNot Applicable

中国健康受试者空腹/餐后状态下单次口服甲硝唑片的随机、开放、两序列、两周期、双交叉人体生物等效性试验

[Translation] A randomized, open-label, two-sequence, two-period, double-crossover bioequivalence study of a single oral dose of metronidazole tablets in Chinese healthy volunteers in the fasting/fed state

研究健康受试者空腹/餐后单次口服受试制剂甲硝唑片（华中药业股份有限公司，规格：0.2g/片）与参比制剂甲硝唑片（商品名：FLAGYL），Winthrop Pharmaceuticals UK Limited/Zentiva/Aventis Pharma Limited/Sanofi，规格：200mg/片）在吸收程度和速度方面是否存在差异，评价受试制剂和参比制剂在空腹/餐后条件下给药时的生物等效性，观察受试制剂和参比制剂在健康受试者中的安全性。

[Translation]

To investigate whether there are differences in the extent and rate of absorption between the test preparation metronidazole tablets (Huazhong Pharmaceutical Co., Ltd., specification: 0.2g/tablet) and the reference preparation metronidazole tablets (trade name: FLAGYL, Winthrop Pharmaceuticals UK Limited/Zentiva/Aventis Pharma Limited/Sanofi, specification: 200mg/tablet) after a single oral administration on an empty stomach/after a meal in healthy subjects, to evaluate the bioequivalence of the test preparation and the reference preparation when administered under empty stomach/after a meal, and to observe the safety of the test preparation and the reference preparation in healthy subjects.

Start Date06 Apr 2021

Sponsor / Collaborator

Hubei Huazhong Pharmaceutical Co. Ltd.

100 Clinical Results associated with Balantidiasis

100 Translational Medicine associated with Balantidiasis

0 Patents (Medical) associated with Balantidiasis

433

Literatures (Medical) associated with Balantidiasis

18 Oct 2024·Biotechnology letters

Breaking resistance: in silico subtractive and comparative genomics approaches for drug targeting in Bacteroides fragilis.

Article

Author: Khan, Kanwal ; Aghayeva, Saltanat ; Zia, Tehreem ; Uddin, Reaz

The purpose of this study was to identify potential novel drug targets for Bacteroides fragilis infections using bioinformatics techniques, such as subtractive and comparative genomics. Bacteroides fragilis is a frequently isolated anaerobic pathogen, particularly in the human digestive tract, where its pathogenesis and persistence are influenced by various virulence factors. By understanding these factors, the study aims to explore alternative therapeutic strategies and provide insights for the development of treatments against B. fragilis infections, particularly as alternatives to antibiotic therapy. A comparative subtractive genomic analysis was performed against the B. fragilis (strain CL07T12C05) to identify unique drug targets. The analysis includes the identification of non-paralogous, non-homologous, essential, and drug target like proteins. Moreover, a comprehensive structural analysis of the protein was conducted utilizing structure modeling and validation techniques, along with network topology analysis. Furthermore, a library comprising approximately 9000 FDA-approved compounds accessible in the DrugBank database was employed to conduct virtual screenings for compounds effective against the designated drug target. The top shortlisted compounds were further studied by employing MD simulations using GROMACS. This approach was chosen due to the established safety, efficacy, pharmacokinetics, and toxicity profiles of these compounds. As a result, B. fragilis (strain CL07T12C05) was found to possess 4595 proteins. Among these, 3518 were identified as non-homologous, 1508 deemed essential for bacterial viability, 348 exhibited drug-like properties, 203 were implicated in virulence, and 135 displayed antibiotic resistance. Following an extensive literature review, the protein Sialic acid O-acetyltransferase was chosen through a hierarchical shortlisting process as a potential therapeutic target. The ongoing research facilitated the repurposing of drug compounds: DB12411, DB02112, DB03591, and DB00192, as cost-effective medications against B. fragilis related infections. MD simulations analysis showed that DB12411 may be a potential drug candidate against Sialic acid O-acetyltransferase from B. fragilis. Through subtractive and comparative genomic analysis, Sialic acid O-acetyltransferase was identified as a promising drug target against Bacteroides fragilis. The findings indicate that compounds targeting this protein could potentially be effective in treating B. fragilis infections. However, further experimental validation is required to conclusively confirm their efficacy.

15 Jun 2024·Internal Medicine

<i>Bacillus cereus</i> Sepsis in a Patient with Severe Alcoholic Hepatitis

Article

Author: Hayashi, Manabu ; Suto, Kazuto ; Abe, Kazumichi ; Fujita, Masashi ; Takahashi, Atsushi ; Ohira, Hiromasa

A 57-year-old woman with a liver injury was referred to our hospital. She had a history of heavy alcohol consumption and had developed severe alcoholic hepatitis. Blood cultures revealed bacteremia caused by Bacillus cereus. The patient was treated with short-term steroid therapy for liver injury and vancomycin administration for B. cereus sepsis, which led to recovery. The findings in the present case suggest the need for empirical therapy with vancomycin in patients with severe alcoholic hepatitis and suspected B. cereus infection.

01 Jun 2024·Veterinary World

Prevalence and diversity of gastrointestinal parasites in long-tailed macaques at Kosamphi Forest Park, Kumphawapi Monkey Garden, and Dong Ling Don Chao Pu Park, North-east Thailand

Article

Author: Puimat, Nattakan ; Phosuk, Issarapong ; Thanchomnang, Tongjit ; Jongthawin, Jurairat ; Banglua, Julalak

Background and Aim: These three parks in North-east Thailand, Kosamphi Forest Park, Kumphawapi Monkey Garden, and Dong Ling Don Chao Pu Park, are internationally recognized for sheltering long-tailed macaques. Overfeeding by tourists and locals significantly increases the frequency of human-macaque encounters. Being close to each other raises the chances of contracting gastrointestinal (GI) parasites. This study was designed to estimate the prevalence and range of GI parasite infections in long-tailed macaques among the three major natural habitats. Materials and Methods: Three hundred fecal samples were collected from long-tailed macaques, with 100 samples from each of the three study sites. The samples underwent Formalin-ethyl acetate concentration technique examination. Parasites were identified based on their morphology and size as observed under a light microscope. Results: About 66.67% of the population had GI parasitic infection. Balantidium coli had the highest occurrence (41.66%), whereas Strongyloides spp. (24.33%), Trichuris spp. (18.33%), Entamoeba coli (10.33%), and Endolimax nana (2.33%) followed next in prevalence. A higher rate of single infections (41%) was reported compared to mixed infections (25.66%). At Dong Ling Don Chao Pu Park, the prevalence rate of B. coli in long-tailed macaques was 70%, markedly higher than those reported at the other two study sites. In these areas, the first known case of B. coli infection occurred in long-tailed macaques. In the Kumphawapi Monkey Garden, the prevalence of Strongyloides spp. and Trichuris spp. infections was significantly greater (45% and 28%, respectively) compared to the other two areas. Conclusion: In northeast Thailand, long-tailed macaques are predominantly infected with B. coli, causing GI protozoal infections. In this primate population of the region, Strongyloides and Trichuris species are common helminths. This study offers new knowledge on parasitic loads in Thai long-tailed macaques, essential for devising effective One Health approaches to prevent and manage zoonotic diseases. Keywords: Dong Ling Don Chao Pu Park, gastrointestinal parasite, Kosamphi Forest Park, Kumphawapi Monkey Garden, long-tailed macaques.

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Balantidiasis

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