Request Demo

Last update 08 May 2025

Balantidiasis

Last update 08 May 2025

Basic Info

Synonyms

B. coli Infection, B. coli Infections, BALANTIDIASIS

+ [32]

Introduction

Infection by parasites of the genus BALANTIDIUM. The presence of Balantidium in the LARGE INTESTINE leads to DIARRHEA; DYSENTERY; and occasionally ULCER.

Drugs associated with Balantidiasis

Metronidazole Benzoate

Target-

Mechanism

DNA synthesis inhibitors

Active Org.-

Originator Org.-

Active Indication

Amebiasis [+6]

Inactive Indication

Gastrointestinal motility disorder

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

China

First Approval Date26 Nov 2002

Clinical Trials associated with Balantidiasis

CTR20231650

/ CompletedNot Applicable

甲硝唑片健康人体生物等效性研究

[Translation] Study on the bioequivalence of metronidazole tablets in healthy volunteers

主要试验目的：在中国健康受试者中评价单次空腹和单次餐后服用安徽宏业药业有限公司生产的甲硝唑片0.2g（规格：0.2g/片；受试制剂）和西班牙sanofi-aventis Ireland Ltd., T/A SANOFL生产的的甲硝唑片200mg（规格：200mg/片；参比制剂）的生物等效性；次要试验目的：观察受试制剂和参比制剂在健康受试者中的安全性。

[Translation]

Primary study objective: To evaluate the bioequivalence of single fasting and single postprandial administration of metronidazole tablets 0.2g (specification: 0.2g/tablet; test preparation) produced by Anhui Hongye Pharmaceutical Co., Ltd. and metronidazole tablets 200mg (specification: 200mg/tablet; reference preparation) produced by sanofi-aventis Ireland Ltd., T/A SANOFL, Spain in healthy Chinese subjects; Secondary study objective: To observe the safety of the test preparation and the reference preparation in healthy subjects.

Start Date09 Jul 2023

Sponsor / Collaborator

Anhui Hongye Pharmaceutical Co. Ltd.

CTR20220468

/ Active, not recruitingNot Applicable

甲硝唑片在健康受试者中随机、开放、两制剂、单次给药、两周期、双交叉空腹/餐后生物等效性试验

[Translation] A randomized, open-label, two-formulation, single-dose, two-period, double-crossover fasting/fed bioequivalence study of metronidazole tablets in healthy subjects

主要目的：以药代动力学参数作为主要终点评价指标，比较口服受试制剂甲硝唑片（生产厂家：江西新赣江药业股份有限公司）与参比制剂甲硝唑片（持证商：Sanofi，商品名：Flagyl®）在健康受试者体内空腹/餐后状态下的药代动力学行为，评价两种制剂在空腹/餐后条件下是否具有生物等效性。次要目的：观察受试制剂甲硝唑片和参比制剂甲硝唑片在健康受试者中的安全性。

[Translation]

Main purpose: To compare the pharmacokinetic behavior of the oral test preparation metronidazole tablets (manufacturer: Jiangxi Xin Ganjiang Pharmaceutical Co., Ltd.) and the reference preparation metronidazole tablets (certificate holder: Sanofi, trade name: Flagyl®) in healthy subjects under fasting/postprandial conditions, using pharmacokinetic parameters as the primary endpoint evaluation indicators, and to evaluate whether the two preparations are bioequivalent under fasting/postprandial conditions. Secondary purpose: To observe the safety of the test preparation metronidazole tablets and the reference preparation metronidazole tablets in healthy subjects.

Start Date21 Feb 2022

Sponsor / Collaborator

Jiangxi New Ganjiang Pharmaceutical Co., Ltd.

CTR20210515

/ CompletedNot Applicable

中国健康受试者空腹/餐后状态下单次口服甲硝唑片的随机、开放、两序列、两周期、双交叉人体生物等效性试验

[Translation] A randomized, open-label, two-sequence, two-period, double-crossover bioequivalence study of a single oral dose of metronidazole tablets in Chinese healthy volunteers in the fasting/fed state

研究健康受试者空腹/餐后单次口服受试制剂甲硝唑片（华中药业股份有限公司，规格：0.2g/片）与参比制剂甲硝唑片（商品名：FLAGYL），Winthrop Pharmaceuticals UK Limited/Zentiva/Aventis Pharma Limited/Sanofi，规格：200mg/片）在吸收程度和速度方面是否存在差异，评价受试制剂和参比制剂在空腹/餐后条件下给药时的生物等效性，观察受试制剂和参比制剂在健康受试者中的安全性。

[Translation]

To investigate whether there are differences in the extent and rate of absorption between the test preparation metronidazole tablets (Huazhong Pharmaceutical Co., Ltd., specification: 0.2g/tablet) and the reference preparation metronidazole tablets (trade name: FLAGYL, Winthrop Pharmaceuticals UK Limited/Zentiva/Aventis Pharma Limited/Sanofi, specification: 200mg/tablet) after a single oral administration on an empty stomach/after a meal in healthy subjects, to evaluate the bioequivalence of the test preparation and the reference preparation when administered under empty stomach/after a meal, and to observe the safety of the test preparation and the reference preparation in healthy subjects.

Start Date06 Apr 2021

Sponsor / Collaborator

Hubei Huazhong Pharmaceutical Co. Ltd.

100 Clinical Results associated with Balantidiasis

100 Translational Medicine associated with Balantidiasis

0 Patents (Medical) associated with Balantidiasis

426

Literatures (Medical) associated with Balantidiasis

01 May 2025·Journal of Pediatric Hematology/Oncology

Alternaria Invasive Infection in Children With Hemato-Oncological Disease: A National Multicenter Report

Article

Author: Sherman, Gilad ; Shachor-Meyouhas, Yael ; Bilavsky, Efraim ; Fisher, Salvador ; Grisaru, Galia ; Sever, Aviv ; Sachs, Nimrod ; Ben Zvi, Haim ; Rosenberg Danziger, Chen

Invasive fungal diseases significantly impact hemato-oncology pediatric patients, with Aspergillus and Candida being the primary culprits. However, pediatric Alternaria infections remain understudied. This study aims to characterize Alternaria infections in pediatric hemato-oncology cases nationwide. This retrospective multicenter observational study reviewed medical records from Israel’s 5 largest tertiary pediatric centers between 2011 and 2023. We identified 22 patients aged 4 to 18 years with invasive Alternaria infection. Predominant diagnoses were acute lymphoid leukemia (55%) and acute myeloid leukemia (23%), with 86% presenting neutropenic fever. Alternaria infections manifested as invasive rhinosinusitis (77%), skin lesions resembling ecthyma (14%), and pulmonary infection (9%). Notably, 76% of sinusitis cases exhibited suggestive symptoms. Voriconazole treatment led to a 90% recovery rate, irrespective of surgery. Two fatalities were unrelated to the infections. This study, the largest on Alternaria infections in children, emphasizes their occurrence in leukemia patients with neutropenic fever, showcasing common clinical presentations and a favorable prognosis despite underlying diseases.

01 Apr 2025·Journal of Medical Primatology

Microbiome‐Metabolomics Analysis of the Impacts of Balantidium Coli Infection in Rhesus Monkeys (Macaca mulatta)

Article

Author: Li, Heling ; Tian, Baohong ; Wang, Hong ; Chen, Xinglong ; Zong, Faliang ; Zhang, Long

ABSTRACTBalantidium coli (B. coli) is a prevalent intestinal parasite in monkeys, significantly impacting their health. Previous studies have demonstrated that B. coli infection in pigs leads to severe dysregulation of the gut microbiota. However, there has been no report on the alterations in fecal microbiota and metabolites in rhesus monkeys infected with B. coli. In order to investigate the differences in gut microbiota and metabolites between healthy rhesus monkeys and those infected with B. coli, we conducted gene sequencing and gas chromatography–mass spectrometry (GC–MS) analysis of fecal samples from 6 healthy rhesus monkeys and 5 rhesus monkeys infected with B. coli. The results revealed significant differences in the composition of gut microbiota between rhesus monkeys infected with B. coli and healthy ones (p < 0.01). The abundance of Campylobacterota was significantly increased (p < 0.01), while the abundance of Bacteroidota was significantly decreased (p < 0.05). Prevotella 9 was the dominant genus in both groups, showing a significant increase in the infected group (p < 0.05). At the species level, Brachyspira hampsonii was significantly increased in the infected group (p < 0.01), whereas Prevotella copri, which was the dominant species in both groups, showed a significant decrease in the infected group (p < 0.05). Metabolomics studies indicated a significant decrease in levels of metabolites such as dihydrolipoamide, 9(Z),11(E)‐Conjugated Linoleic Acid, and 8,9‐DiHETrE within fecal samples from rhesus monkeys infected with B. coli (p < 0.05). Correlation analysis of the microbiome and metabolome suggested a close relationship between differential microbiota and metabolites. In conclusion, this study suggests that the colonization of B. coli is associated with dysbiosis of the monkey gut microbiota. This study provides a new insight that using intestinal microbes instead of antibiotics to treat balantidiosis can also serve as a reference for further research on the relationship between gut microbiota and metabolomics in host infections by other protozoa.

01 Apr 2025·The Plant Pathology Journal

Bio-efficacy of Nanosilicon in Regulating Oxidative Activity to Control Rice Seedlings Rot Disease Caused by Burkholderia glumae

Article

Author: Ibrahim, Muhamad Syazlie Che ; Rajoo, Tamilselvan R Govinda ; Ng, Lee Chuen ; Ahmad, Aziz

Bacterial panicle blight and seedling rot diseases in rice plants (Oryza sativa L.) are caused by the pathogenic bacterial Burkholderia glumae. The nanosilicon treatment is gaining attraction but its effectiveness towards B. glumae infection in rice seedlings through regulating enzymatic activities remains largely unexplored. This study aimed to evaluate the bio-efficacy of nanosilicon in controlling seedling rot disease through regulation of peroxidase and polyphenol oxidase enzymes after challenge infected with B. glumae in rice variety MR297 and PadiU Putra. Nanosilicon was applied as seed priming in germination testing at 0, 300, 600, and 900 ppm on both rice varieties before B. glumae inoculation. Both rice seed varieties primed with nanosilicon at 600 ppm exhibited a significant increase in seedling germination performances over control. The rice seedling of MR297 was more responsive to nanosilicon at 600 ppm with only 17.78% of disease severity index over 26.67% in PadiU Putra and was therefore selected for the enzymatic activity screening. The results showed that the foliar spray of nanosilicon rice plants (MR297) significantly increased both peroxidase (POX) at 24 h and polyphenol oxidase (PPO) at 48 h after B. glumae inoculation with 20.44/min/g and 7.46/g activities, respectively. In addition, the plant growth performances were significantly increased compared with control under the same treatment. This demonstrates nanosilicon’s potential to control rice seedling rot disease by regulating POX and PPO activities and hence promote plant growth. The application of nanosilicon is an environmentally friendly approach for controlling B. glumae infection at the early rice growing stage.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Balantidiasis

Basic Info

Related

Analysis