Werner Syndrome

Genflow Biosciences Plc ("Genflow" or "the Company") LONDON, Feb. 01, 2024 (GLOBE NEWSWIRE) -- The Company (LSE:GENF) (OTCQB:GENFF), an emerging leader in the field of longevity research developing therapeutics that potentially halt or slow the ageing process, is pleased to provide a year-end review and summary of its progress during 2023 and defined strategic priorities for 2024. The Company achieved many significant accomplishments throughout the year across all aspects of its business. The full year-end review can be viewed on Genflow’s website: https://genflowbio.com/genflow-biosciences-plc-2023-year-in-review/. Key 2023 Highlights: Genflow expanded its intellectual property portfolio with a provisional patent application for editing the SIRT6 gene, linked to longevity and age-related diseases.Began trading on the OTCQB Venture Market in the US under the ticker GENFF, aligned to its US-focused strategy. Genflow received positive feedback from the Federal Agency for Medicines and Health Products in Belgium on the design of Phase I/II clinical trials for its lead drug candidate, GF-1002, in NASH patients. Genflow made several key appointments, including Capital Plus Partners Ltd as Joint Broker in order to access both institutional and international investment; Harbor Access for investor relations support; and Prof. Dr. Sven Francque, an expert in nonalcoholic fatty liver disease and Prof. Dr. Mary E. Rinella, a fatty liver disease specialist to its Scientific Advisory Board. Strategic Priorities in 2024: Genflow awarded 2.89 million Euros in two new grants that will broaden its research pipeline and expand the size of its therapeutic markets over the next three years. (Refer to press release: https://www.globenewswire.com/news-release/2024/01/18/2811445/0/en/Genflow-Biosciences-Partners-with-Revatis-SA-and-EXO-Biologics-in-Groundbreaking-Aging-Research-Fueled-by-Two-Major-Research-Grants.html) Genflow to undertake key Investigational New Drug (IND)-enabling development activities that will help define the pharmacological and toxicological properties of its lead drug candidate, GF-1002, and its potential benefits for NASH patients. Initial site selection and QMS framework for clinical readiness, expected by the end of 2025 for the NASH program. Commence preliminary discussions with the European Medicines Agency (EMA) on Mechanism of Action (MoA) data for Orphan Drug Application (ODA) for our second compound GF-3001, targeting Werner Syndrome. Select Contract Development and Manufacturing Organization (CDMO) for advancing the GMP manufacturing of the NASH clinical lot of lead drug candidate, GF-1002.Develop and implement project management, budgeting and governance for collaborative partners, in line with clinical and pre-clinal activities that will enable IND applications.Moving key patent applications under the Patent Cooperation Treaty (PCT) to the national phase, while further expanding our development pipeline with new products and new indications. Dr. Eric Leire, CEO of Genflow commented: “The milestones we reached in 2023 were numerous, and I commend our team for their exceptional commitment to execution and delivery. While 2023 was a pivotal year, we’re poised for an even stronger 2024, as we shift focus to scaling development of our lead drug candidate, GF-1002, and its potential benefits for NASH patients. With the support of our partners and the backing of new grants, we are poised to make meaningful advancements in the field of longevity.” Contacts Genflow BiosciencesHarbor AccessDr Eric Leire, CEOJonathan Paterson, Investor Relations+32-477-495-881+1 475 477 9401 Jonathan.Paterson@Harbor-access.com Joint Corporate Brokers Clear Capital MarketsCapital Plus Partners LtdBob Roberts, +44 203 869 6080Dominic Berger, +44 203 821 6167 Keith Swann, +44 0203 821 6169 Jon Critchley, +44 0203 821 6168 About Genflow Biosciences Established in 2020, Genflow Biosciences Ltd is a UK-based biotechnology company, with R&D facilities in Belgium, developing and researching potential novel therapeutics that halt or slow the ageing process enabling society to live longer, healthier lives. Genflow Biosciences’ lead compound GF-1002 works through the delivery of a centenarian variant of the SIRT6 gene, which has yielded promising preclinical results. Genflow Biosciences expects to commence a clinical trial in 2024 to study the potential benefit of GF-1002 in non-alcoholic steatohepatitis (NASH) for which there are few or no approved therapies. By treating ageing as a risk factor to disease, Genflow Biosciences aims to reduce the financial, emotional, and social costs of an ageing population. For more information: www.genflowbio.com DISCLAIMER The contents of this announcement have been prepared by, and are the sole responsibility of, the Company. This announcement may contain forward-looking statements. The forward-looking statements include, but are not limited to, statements regarding the Company's or the Directors' expectations, hopes, beliefs, intentions or strategies regarding the future. In addition, any statement that refers to projections, forecasts or other characterisations of future events or circumstances, including any underlying assumptions, is a forward-looking statement. 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Secures Two Research Grants from Belgium's New Technological Innovation Partnership LONDON, UK / ACCESSWIRE / January 18, 2024 / The Company (LSE:GENF)(OTCQB:GENFF), an emerging leader in the field of longevity research developing therapeutics that potentially halt or slow the ageing process is pleased to announce two significant new research programs in collaboration with Revatis SA and EXO Biologics, backed by substantial non-diluting and non-reimbursable research grants by the Government of Wallonia in Belgium. Funding for the two research programs, as part of the Wallonia Recovery Plan by the Walloon Government in Belgium, will be disbursed annually to the Company, contingent upon Genflow and its collaborators achieving specific, activity-based milestones. Continued receipt of the grants by Genflow is dependent on the parties meeting predefined criteria each applicable year. Technological Innovation Partnership (ATMP) The two research programs are a part of a broader innovation partnership that the Walloon Government has launched, dedicated to Advanced Therapy Medicinal Products (ATMPs). The partnership boasts a substantial budget of 81 million euros, a mix of 60% public funding and 40% private contributions from various companies, spread over three years. This initiative is a collaborative effort involving BioWin, the Health Cluster of Wallonia and the Public Service of Wallonia, representing a significant commitment to advancing medical research and development in the region. Sarcopenia Research Program with Revatis SA Genflow, together with Revatis SA, has launched a 3-year sarcopenia research program, generously funded by a grant totalling 1.34 million euros. Sarcopenia, the progressive loss of muscle mass and function associated with ageing, poses a significant health risk and affects the quality of life for millions of elderly people worldwide. This collaborative effort aims to expand and diversify Genflow's research pipeline, addressing this growing concern as the global population ages. The partnership will leverage both companies' expertise to develop innovative solutions and contribute valuable insights into the mechanisms of age-related muscle deterioration. mRNA Delivery Research with EXO Biologics Genflow and EXO Biologics have initiated a 3-year scientific program, supported by a grant of 1.55 million euros. The project focuses on the development of a novel mRNA delivery system using exosomes to encapsulate and transport Genflow's proprietary centenarian SIRT6 gene. This cutting-edge approach aims to harness the natural advantages of exosomes, such as enhanced stability, improved cellular uptake, reduced immunogenicity, minimal toxicity, natural cargo sorting and reduced off-target effects, among others. This endeavour not only demonstrates Genflow's momentum in leading-edge research, but also holds the potential to revolutionize therapeutic interventions for Werner Syndrome, an accelerated ageing condition and holds great promised for a range of other age-related conditions. Dr. Eric Leire, CEO of Genflow commented: "We are excited to embark on this exciting new research, which aligns with our quest to understand and alleviate the impacts of ageing. Launching both of these programs represents a strategic move to enhance our research capabilities, while contributing to the understanding of age-related conditions. Both of these strategic initiatives will strengthen Genflow's position at the forefront of ageing-related research, and its mission to improve the health and well-being of older adults." The information communicated in this announcement is inside information for the purposes of Article 7 of Regulation 596/2014. For further information please contact: Genflow Biosciences Plc Dr Eric Leire Chief Executive Officer +32 477 495 881 Clear Capital Markets Joint Corporate Broker Bob Roberts +44 203 869 6080 Capital Plus Partners Ltd Joint Corporate Brokers Dominic Berger Keith Swann Jon Critchley +44 203 821 6167 +44 0203 821 6169 +44 0203 821 6168 Harbor Access Investor Relations Jonathan Paterson +1-475-477-9401 About Genflow Biosciences Established in 2020, Genflow Biosciences Ltd is a UK-based biotechnology company, with R&D facilities in Belgium, developing and researching potential novel therapeutics that halt or slow the ageing process enabling society to live longer, healthier lives. Genflow Biosciences lead compound is GF-1002, works through the delivery of a centenarian variant of the SIRT6 gene which has yielded promising preclinical results. Genflow Biosciences expects to commence a clinical trial in 2024 to study the potential benefit of GF-1002 in non-alcoholic steatohepatitis (NASH) for which there are few or no-approved therapies. By treating ageing as a risk factor to disease, Genflow Biosciences aims to reduce the financial, emotional, and social costs of an ageing population. For more information: About Revatis SA Revatis SA is a biotechnology firm based in Luxemburg specializing in the collection, production and storage of autologous muscle-derived mesenchymal stem cells (MdMSC) for immediate therapeutic use or storage for further processing. RevaTis technology is minimally invasive and offers benefits for generating a large number of autologous stem cells. Their expertise in sarcopenia research makes them a valuable partner in addressing muscle deterioration in the elderly. For more information: About EXO Biologics EXO Biologics is Belgian biotech company committed to developing biopharmaceuticals using Extracellular Vesicles (EVs). Their work in mRNA encapsulation and delivery is revolutionizing the approach to genetic and cellular therapies. For more information: This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit . SOURCE: Genflow Biosciences PLC View the original press release on accesswire.com

LONDON, Jan. 18, 2024 (GLOBE NEWSWIRE) -- Genflow Biosciences Plc (Genflow or the "Company”) (LSE:GNF) (OTCQB:GENFF), an emerging leader in the field of longevity research developing therapeutics that potentially halt or slow the ageing process, in collaboration with Revatis SA and EXO Biologics, is proud to announce the initiation of two significant research programs backed by substantial non-diluting and non-reimbursable research grants by the Government of Wallonia in Belgium. Both of these strategic initiatives will strengthen Genflow’s position at the forefront ageing-related research, and its mission to improve the health and well-being of older adults. Technological Innovation Partnership (ATMP) Funding for the two research programs, as part of the Wallonia Recovery Plan by the Walloon Government in Belgium, will be disbursed annually to the Company, contingent upon Genflow and its collaborators achieving specific, activity-based milestones. Continued receipt of the grants by Genflow is dependent on the parties meeting predefined criteria each applicable year. The two research programs are a part of a broader innovation partnership that the Walloon Government has launched, dedicated to Advanced Therapy Medicinal Products (ATMPs). The partnership boasts a substantial budget of 81 million euros, a mix of 60% public funding and 40% private contributions from various companies, spread over three years. This initiative is a collaborative effort involving BioWin, the Health Cluster of Wallonia and the Public Service of Wallonia, representing a significant commitment to advancing medical research and development in the region. Sarcopenia Research Program with Revatis SA Genflow, together with Revatis SA, has launched a 3-year sarcopenia research program, generously funded by new grants totalling 1.34 million euros. Sarcopenia, the progressive loss of muscle mass and function associated with ageing, poses a significant health risk and affects the quality of life for millions of elderly people worldwide. This collaborative effort aims to expand and diversify Genflow's research pipeline, addressing this growing concern as the global population ages. The partnership will leverage both companies' expertise to develop innovative solutions and contribute valuable insights into the mechanisms of age-related muscle deterioration. mRNA Delivery Research with EXO Biologics Genflow and ExoBiologics have initiated a 3-year scientific program, supported by a grant of 1.55 million euros. The project focuses on the development of a novel mRNA delivery system using exosomes to encapsulate and transport Genflow’s proprietary centenarian SIRT6 gene. This cutting-edge approach aims to harness the natural advantages of exosomes, such as enhanced stability, improved cellular uptake, reduced immunogenicity, minimal toxicity, natural cargo sorting and reduced off-target effects, among others. This endeavour not only demonstrates Genflow's momentum in leading-edge research but also holds the potential to revolutionize therapeutic interventions for Werner Syndrome, an accelerated ageing condition and holds great promised for a range of other age-related conditions. Dr. Eric Leire, CEO of Genflow commented: “We are excited to embark on this exciting new research, which aligns with our quest to understand and alleviate the impacts of ageing. Launching both of these programs represents a strategic move to enhance our research capabilities, while contributing to the understanding of age-related conditions. With the support of our partners and the backing of these two grants, we are poised to make meaningful advancements in the field of longevity." Contacts Dr Eric Leire, +32-477-495-881 CEO, Genflow Biosciences Clear Capital Markets Joint Corporate Broker Bob Roberts, +44 203 869 6080 Capital Plus Partners Ltd Dominic Berger, +44 203 821 6167 Keith Swann, +44 0203 821 6169 Jon Critchley, +44 0203 821 6168 Investor Relations Harbor Access Jonathan Paterson, 1-475-477-9401 Jonathan.Paterson@Harbor-Access.com About Genflow Biosciences Established in 2020, Genflow Biosciences Ltd is a UK-based biotechnology company, with R&D facilities in Belgium, developing and researching potential novel therapeutics that halt or slow the ageing process enabling society to live longer, healthier lives. Genflow Biosciences lead compound is GF-1002, works through the delivery of a centenarian variant of the SIRT6 gene which has yielded promising preclinical results. Genflow Biosciences expects to commence a clinical trial in 2024 to study the potential benefit of GF-1002 in non-alcoholic steatohepatitis (NASH) for which there are few or no-approved therapies. By treating ageing as a risk factor to disease, Genflow Biosciences aims to reduce the financial, emotional, and social costs of an ageing population. For more information: About Revatis SA Revatis SA is a biotechnology firm based in Luxemburg specializing in the collection, production and storage of autologous muscle-derived mesenchymal stem cells (MdMSC) for immediate therapeutic use or storage for further processing. RevaTis technology is minimally invasive and offers benefits for generating a large number of autologous stem cells. Their expertise in sarcopenia research makes them a valuable partner in addressing muscle deterioration in the elderly. For more information: About EXO Biologics EXO Biologics is Belgian biotech company committed to developing biopharmaceuticals using Extracellular Vesicles (EVs). Their work in mRNA encapsulation and delivery is revolutionizing the approach to genetic and cellular therapies. For more information: