Last update 01 Nov 2024

Andropause

Last update 01 Nov 2024

Basic Info

Synonyms

Andropause, Change of Life, Male, Climacteric, Male

+ [10]

Introduction

An endocrine state in men, characterized by a significant decline in the production of TESTOSTERONE; DEHYDROEPIANDROSTERONE; and other hormones such as HUMAN GROWTH HORMONE. Andropause symptoms are related to the lack of androgens including DEPRESSION, sexual dysfunction, and OSTEOPOROSIS. Andropause may also result from hormonal ablation therapy for malignant diseases.

Drugs associated with Andropause

Actaea racemosa extract

Target-

Mechanism-

Active Org.

Schaper & Brümmer GmbH & Co. KG [+2]

Originator Org.

Bionorica SE

Active Indication

Andropause [+1]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date01 Apr 2014

Testosterone Cypionate

Target

Mechanism

AR agonists

Active Org.-

Originator Org.-

Active Indication

Andropause [+5]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.-

First Approval Date12 Jul 1999

Sanhuangxiexin Decoction

Target-

Mechanism-

Active Org.

Ohsugi Pharmaceutical Co., Ltd.

Originator Org.

Ohsugi Pharmaceutical Co., Ltd.

Active Indication

Andropause [+5]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date25 Dec 1986

Clinical Trials associated with Andropause

ChiCTR2400081668 / CompletedNot ApplicableIIT

Skeletal muscle mass index evaluation of Shibao decoction and other methods in the treatment of Late-Onset Hypogonadism clinical study

Start Date05 Jan 2022

Sponsor / Collaborator-

TCTR20170919003 / Not yet recruitingPhase 2/3

A randomized, placebo controlled trial comparing the efficacy of a combination of oral 5mg finasteride and 5% minoxidil solution versus 5%minoxidil alone in treatment of female pattern hair loss (FPHL) in post- menopausal women.

Start Date01 Oct 2017

Sponsor / Collaborator-

IRCT2016120127216N5 / CompletedPhase 2IIT

Effect of education about andropause health on level of the knowledge and attitude of men referring to the? Education and training retirement center of Shiraz

Start Date21 Dec 2016

Sponsor / Collaborator-

100 Clinical Results associated with Andropause

100 Translational Medicine associated with Andropause

0 Patents (Medical) associated with Andropause

143

Literatures (Medical) associated with Andropause

01 Aug 2024·Journal of Medicinal Food

Improvement in Testosterone Production by Acorus gramineus for the Alleviation of Andropause Symptoms

Article

Author: Lee, Yoo-Hyun ; Kim, Seokho ; Son, Rak Ho ; Kim, Hongeun ; Lee, Jeong Yoon ; Kim, Sang-Yoon ; Yeon, Sung-Hum ; Park, Chae Lee

Acorus gramineus has a number of beneficial effects, including protective effects against age-related disorders. In this study, the effects of A. gramineus on testosterone production and andropause symptoms were evaluated. We first treated TM3 mouse Leydig cells, responsible for testosterone production, with A. gramineus aqueous extract at different concentrations. In TM3 cells, the testosterone concentration increased in a concentration-dependent manner compared with those in the control. In addition, at 400 μg/mL extract, the mRNA expression level of the steroidogenic enzyme CYP11A1 was increased. Subsequently, 23-week-old Sprague-Dawley (SD) rats exhibiting an age-related reduction in serum testosterone (approximately 80% lower than that in 7-week-old SD rats) were administered A. gramineus aqueous extract for 8 weeks. Serum total testosterone and free testosterone levels were higher and serum estradiol, prostate-specific antigen levels, and total cholesterol levels were lower in the AG50 group (A. gramineus aqueous extract 50 mg/kg of body weight/day) than in the OLD (control group). The AG50 group also showed significant elevations in sperm count, grip strength, and mRNA expression of StAR, CYP11A1, 17β-HSD, and CYP17A1 compared with those in the OLD group. In conclusion, A. gramineus aqueous extract facilitated steroidogenesis in Leydig cells, elevated testosterone levels, lowered serum estradiol and total cholesterol levels, and increased muscle strength and sperm count, thus alleviating the symptoms of andropause. These findings suggest that A. gramineus aqueous extract is a potentially effective therapeutic agent against various symptoms associated with andropause.

01 Jul 2024·Cureus

Andropause in Diabetic and Non-diabetic Males: A Cross-Sectional Observational Study in Western India.

Article

Author: Kadiwala, Ramiz S ; Dhadwad, Jagannath S

Andropause is defined as late-onset hypogonadism that increases with advancing age and is diagnosed based on symptoms of hypogonadism like loss of libido, loss of morning penile tumescence, and laboratory confirmation of low testosterone. Unlike menopause, it is a slow and progressive condition with varying symptoms and presentations. There is very little awareness and insufficient utilization of screening methods, and the majority of the cases remain undiagnosed. This study was done to get deeper insight into this topic and elicit correlations among different variables. Objectives The primary objective is to assess the prevalence of andropause in diabetic and non-diabetic males aged 40-60 years in the Maharashtra state of western India. Material and methods After ethics committee clearance, exclusion criteria were applied, and 120 participants were enrolled over a period of 21 months. All enrolled subjects were thoroughly evaluated for andropause symptoms. An early morning venous blood sample was taken and sent for routine blood tests, including HbA1c, serum total testosterone, and serum luteinizing hormone. Total testosterone values were compared in patients with symptoms of hypogonadism, loss of libido, and erectile dysfunction. The effects of HbA1c levels, duration of diabetes, body mass index (BMI), smoking, alcoholism, and hypertension on hypogonadism and low testosterone were assessed. Luteinizing hormone levels were compared among the case and control groups in subjects with low total testosterone. Results Total testosterone levels were low for age, loss of libido and erectile dysfunction were more common, and symptoms of hypogonadism appeared at an earlier age in diabetics compared to non-diabetics. The duration of diabetes and HbA1c had a negative impact on serum testosterone levels and andropause symptoms. Diabetic patients with low testosterone levels had significantly lower LH levels. Conclusions Andropause is a syndrome of hypogonadism that occurs due to low serum testosterone levels. This study puts emphasis on secondary hypogonadism playing an important role in diabetic patients, causing the early occurrence of andropause in them. Glycemic control and BMI have a significant effect on both andropause symptoms and total testosterone levels, necessitating strict glycemic control and lifestyle modifications to delay or prevent the occurrence of andropause.

31 Oct 2023·The Journal of Sexual Medicine

Couplepause: deconstructing sick menopause and andropause during midlife

Article

Author: Nappi, Rossella E ; Jannini, Emmanuele A ; Rozenberg, Serge ; Schaudig, Katrin ; Giraldi, Annamaria G E

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Andropause

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