Last update 01 Nov 2024

Trichomonas Vaginitis

Last update 01 Nov 2024

Basic Info

Synonyms

Human Trichomoniases, Human Trichomoniasis, Leukorrhea vaginalis - trichomonal

+ [38]

Introduction

Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.

Drugs associated with Trichomonas Vaginitis

Metronidazole Benzoate

Target-

Mechanism

DNA synthesis inhibitors

Active Org.-

Originator Org.-

Active Indication

Amebiasis [+6]

Inactive Indication

Gastrointestinal motility disorder

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date26 Nov 2002

ZhiMiKang

Target-

Mechanism-

Active Org.

Tonghua Golden-Horse Pharmaceutical Industry Co., Ltd.

Originator Org.

Tonghua Golden-Horse Pharmaceutical Industry Co., Ltd.

Active Indication

Bacterial Vaginosis [+2]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date01 Jan 1998

Metronidazole

Target-

Mechanism

DNA synthesis inhibitors

Active Org.

Baxter Healthcare Corp. [+14]

Originator Org.

Pfizer Inc.

Active Indication

Giardiasis [+24]

Inactive Indication

Complicated intra-abdominal infection [+5]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date01 Jan 1960

Clinical Trials associated with Trichomonas Vaginitis

NCT05383521 / Not yet recruitingNot ApplicableIIT

Oral Tinidazole Treatment of Refractory Trichomonas Vaginitis

We compare two oral tinidazole regimens for refractory trichomonas vaginitis.

Start Date01 Dec 2025

Sponsor / Collaborator

Peking University Shenzhen Hospital

IRCT20240529061938N1 / SuspendedPhase 3IIT

Comparison of the effect of violet plant vaginal gel and metronidazole tablet on treatment of trichomonas vaginalis

Start Date21 Jul 2024

Sponsor / Collaborator-

NCT06261840 / Not yet recruitingPhase 4IIT

Refining Treatment Options for Trichomonas Vaginalis Infection in Women and Men: A Comparative Analysis of Oral Multi-Dose Metronidazole and Single-Dose Secnidazole

This is a multi-centered, randomized, open-label, parallel, phase IV clinical trial comparing the effectiveness and cost-effectiveness of oral multi-dose metronidazole (MTZ) and oral single-dose secnidazole (SEC) for the treatment of Trichomonas vaginalis in both women and men.

Start Date01 Jul 2024

Sponsor / Collaborator

The University of Alabama at Birmingham

[+1]

100 Clinical Results associated with Trichomonas Vaginitis

100 Translational Medicine associated with Trichomonas Vaginitis

0 Patents (Medical) associated with Trichomonas Vaginitis

909

Literatures (Medical) associated with Trichomonas Vaginitis

01 Dec 2024·Journal of Structural Biology

Three-dimensional cellular architecture of the sigmoid filament in Trichomonas vaginalis

Article

Author: Ortiz, Sharmila ; Benchimol, Marlene ; Verdan, Raphael ; Fiama das Neves Ortiz, Sharmila

Trichomonas vaginalis is a parasite protozoan that causes human trichomoniasis, a sexually transmitted infection (STI) that affects more than 156 million people worldwide. T. vaginalis contains an uncommon and complex cytoskeleton constituting the mastigont system, formed by several fibers and proteinaceous structures associated with basal bodies. Among these structures is the pelta-axostylar complex made of microtubules and striated filaments such as the costa and the parabasal filaments. In addition, some structures are poorly known and studied, such as the sigmoid filament and the X-filament. Here, we have isolated the Trichomonas vaginalis cytoskeleton and used UHR-SEM (ultra-high resolution scanning electron microscopy), tomography, immunofluorescence, immunolabeling, and backscattered electrons on SEM, negative staining to model the three-dimensional architecture and possible function of the sigmoid.

01 Apr 2024·Experimental Parasitology

Stimulation of microvesicle secretion in Trichomonas vaginalis

Article

Author: de Souza, Wanderley ; Benchimol, Marlene ; Santana de Andrade, Júlio César

Trichomonas vaginalis is an extracellular flagellate protozoan and the etiological agent of human trichomoniasis, a sexually transmitted infection (STI) with a high incidence. Several reports have shown that this protozoan releases microvesicles into the culture medium, which show high potential in modulating cell-to-cell communication and the host response to infections. However, the biogenesis of these vesicles has not been analyzed in detail. In the present study, high-resolution ion scanning microscopy (SEM) and transmission electron microscopy (TEM) were used to analyze the surface of control cells and cells incubated in the presence of Ca²⁺ alone or with A 23187 calcium ionophore. Two different strains of T. vaginalis were analyzed. Most control cells displayed relatively smooth surfaces, whereas cells incubated with Ca²⁺ had many surface projections of variable shape and size (from 40 nm to around 1 μm). Quantitative analyses were performed directly in the scanning electron microscope and showed a significant increase in the number of cells with surface projections after incubation in the presence of calcium. TEM showed that treated cells presented several cytoplasmic multivesicular structures, suggesting membrane fusion and exosomes in the extracellular medium. The amount and size of the released vesicles were quantitatively analyzed using light scattering and TEM on negatively stained samples. The observations show that incubation of both parasite strains in the presence of Ca²⁺ significantly increased the release of microvesicles into the extracellular medium in a time-dependent process. Sequential incubation in the presence of Ca²⁺ and the calcium ionophore A23187 increases the presence of vesicles on the parasite surface only at a short incubation time (5 min). Transmission electron microscopy showed that at least part of the vesicles are originated from cytoplasmic multivesicular structures. This information contributes to a better understanding of the biogenesis of extracellular vesicles secreted by T. vaginalis.

09 Feb 2024·Medicine

Investigation of the relationship between the changes in vaginal microecological enzymes and human papillomavirus (HPV) infection

Article

Author: Li, Jiawei ; Jiang, Li ; Jin, Haihong ; Wang, Huifang ; Wang, Chunhua ; Meng, Jin

This study aims to investigate the relationship between the human papillomavirus (HPV) infection and the altered vaginal microecological environment of patients. Initially, HPV genotyping and microecological detection were performed in 1281 subjects in the Department of Obstetrics and Gynecology of The First Hospital of Qinhuangdao (Qinhuangdao, China). The relationship between the enzymes of vaginal microecology, that is, proline aminopeptidase and acetylglucosaminidase, and vaginal inflammatory diseases, as well as the prognosis of HPV infection, was analyzed. The experimental findings indicated a close relationship between the expression of positive prolyl aminopeptidase and trichomonas vaginitis, as well as bacterial vaginitis. In addition, the expression of acetylglucosaminidase is closely associated with trichomonas vaginitis and vulvovaginal candidiasis. Furthermore, the observations indicated that positive prolyl aminopeptidase and acetylglucosaminidase could increase the risk of various subtypes of HPV infection in patients. The receiver operating characteristic curve analysis presented that the expression of prolyl aminopeptidase and acetylglucosaminidase could offer exceptional diagnostic efficacy, indicating their association with persistent HPV infection. In summary, our results highlighted that the expression of positive prolyl aminopeptidase and acetylglucosaminidase in the vaginal microecology could be substantially correlated to the occurrence and the development of vaginal inflammatory diseases, as well as the outcome and the risk of persistent HPV infection.

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Trichomonas Vaginitis

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