Rejection of pancreas transplant

After a kidney or a simultaneous kidney-pancreas transplant, some patients may face problems with their new organs. This happens because the body sometimes makes a mistake and tries to get rid of the organ. This problem is called "rejection". One type of rejection is known as Acute T cell mediated rejection (TCMR). This can lead to many problems or even stop the transplant from working.
Doctors give strong steroids to treat this problem, but there are no rules for how much steroid to give. Too much steroids can cause problems like heart and bone problems, bad infections, and weight gain. That's why we need to find the right dose of steroids for each person to treat this.
TACKLE-IT is a study that will try to find the right steroid dose for treating rejection.

本研究考察健康受试者在餐后条件下，单次口服由杭州中美华东制药有限公司提供的吗替麦考酚酯干混悬剂（受试制剂，规格：31.8%）或由中外製薬株式会社持证的吗替麦考酚酯干混悬剂（参比制剂，商品名：Cellcept®，规格：31.8%）的药动学特征，评价两制剂的生物等效性及安全性，为该受试制剂注册申请提供依据。

本研究考察健康受试者在空腹条件下，单次口服由杭州中美华东制药有限公司提供的吗替麦考酚酯干混悬剂（受试制剂，规格：31.8%）或由中外製薬株式会社持证的吗替麦考酚酯干混悬剂（参比制剂，商品名：Cellcept®，规格：31.8%）的药动学特征，评价两制剂的生物等效性及安全性，为该受试制剂注册申请提供依据。