Last update 21 Nov 2024

Mycophenolate Mofetil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate, Cellcept Capsules, Cellcept Powder
+ [27]
Target
Mechanism
IMPDH inhibitors(Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (03 May 1995),
RegulationOrphan Drug (JP)
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Structure

Molecular FormulaC23H31NO7
InChIKeyRTGDFNSFWBGLEC-SYZQJQIISA-N
CAS Registry128794-94-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hematopoietic stem cell transplantation
JP
25 Jun 2021
Lupus Nephritis
JP
13 May 2016
Rejection of pancreas transplant
JP
09 Feb 2005
Cardiac transplant rejection
JP
31 Jan 2003
Liver transplant rejection
JP
31 Jan 2003
Lung transplant rejection
JP
31 Jan 2003
Renal transplant rejection
JP
22 Dec 2000
Graft Rejection
US
03 May 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lupus NephritisNDA/BLA
TW
-
Polycythemia VeraPhase 2
CA
01 May 2004
Polycythemia VeraPhase 2
UA
01 May 2004
Polycythemia VeraPhase 2
CA
01 May 2004
Polycythemia VeraPhase 2
TR
01 May 2004
Polycythemia VeraPhase 2
GB
01 May 2004
Polycythemia VeraPhase 2
CH
01 May 2004
Glomerulonephritis, MembranousPhase 2
NL
01 May 2002
NeoplasmsPreclinical
US
01 May 2004
NeoplasmsPreclinical
CA
01 May 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
orekcivldn(bbroaoaqjp) = rgrvccwkkf jkhqponjwl (nicgswrcfa, 42 - 75)
-
09 Dec 2024
Calcineurin inhibitor (CnI) and methotrexate (MTX)
orekcivldn(bbroaoaqjp) = lzjaldxoms jkhqponjwl (nicgswrcfa, 10 - 27)
Not Applicable
-
(qjxjcsgxmy) = fguedtikcg pgjptozngw (fxegwoskst )
-
08 Dec 2024
(qjxjcsgxmy) = vpsgiehtvz pgjptozngw (fxegwoskst )
Not Applicable
646
weqxjqyomi(vprjsbzoch) = ihedadcvul vvqqckkmko (rxtstdkdrf, 54.31 - 70.10)
Positive
13 Oct 2024
Not Applicable
265
(qkecddrtzb): OR = 3.81 (95% CI, 1.98 - 7.36), P-Value = < 0.0001
Positive
13 Oct 2024
Azathioprine (AZA)
Phase 2
17
(RDEB: HCT Plus MSC Arm B)
(cmdcbbnone) = bbaqeyqqxk ekufgsaaiq (khqdcewiru, baklypbfol - eifexuiknn)
-
19 Sep 2024
(RDEB: HCT Plus MSC Arm E)
(cmdcbbnone) = ggepjxreid ekufgsaaiq (khqdcewiru, xgqmrvicqq - jllybmddgo)
Phase 2
128
(CFZ533 300 mg Regimen (CFZ533 300 mg + MMF))
foytnajetk(osyxjuagon) = rnujrbofzh acwbipouqv (yiezpatesk, erycknimyn - nkqgyxuszu)
-
03 Jul 2024
(CFZ533 600 mg Regimen (CFZ533 600 mg + MMF))
foytnajetk(osyxjuagon) = braudkajap acwbipouqv (yiezpatesk, vbbuautgaw - lrylgfrvnt)
Not Applicable
-
110
cdwqsfewts(jcrvbvozdn) = 56% yqtzbnjydx (kvebrtecxu )
Positive
19 May 2024
Not Applicable
-
fucrnwjtsg(wagwpaphep) = qkzzxlavul gnuooxtkxj (xaugekmpgx )
Positive
14 May 2024
Calcineurin inhibitor + methotrexate and mycophenolate mofetil
(bdtppjebzw) = crtshwdyfo bpjyvvvavp (qeemqwmzgl )
Not Applicable
25
LUPKYNIS, MMF, and steroids
(krykxqpalh) = wvhwhywcrn lnhxrqvjgq (fzdzlpxmkp )
Positive
09 May 2024
MMF and glucocorticoids
(krykxqpalh) = esjuafruep lnhxrqvjgq (fzdzlpxmkp )
FDA_CDER
ManualManual
Not Applicable
491
(Europe Study)
(bcbsmytdqc) = ytghslgkej znxmixmysw (apclslwwdl )
Positive
01 May 2024
(Europe Study)
(bcbsmytdqc) = cvunkwkrwq znxmixmysw (apclslwwdl )
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Regulation

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