Last update 01 Nov 2024

Facial Hemiatrophy

Last update 01 Nov 2024

Basic Info

Synonyms

ATROPHY, HEMIFACIAL, ROMBERG, Atrophies, Hemifacial, Atrophies, Progressive Hemifacial

+ [111]

Introduction

A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.

Drugs associated with Facial Hemiatrophy

Mesenchymal stem cell therapy (K-STEMCELL)

Target-

Mechanism

Cartilage replacements [+3]

Active Org.

R Bio Co., Ltd. [+1]

Originator Org.

R Bio Co., Ltd.

Active Indication

Osteoarthritis, Knee [+1]

Inactive Indication

Cerebral Infarction [+11]

Drug Highest PhasePhase 3

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

VascoStem

Target-

Mechanism-

Active Org.

R Bio Co., Ltd.

Originator Org.

R Bio Co., Ltd.

Active Indication

Facial Hemiatrophy [+1]

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Facial Hemiatrophy

ChiCTR2400081791 / RecruitingNot ApplicableIIT

Quantitative Analysis of Tissue Defects in Progressive Hemifacial Atrophy Based on Facial Anatomical Zone

Start Date12 Mar 2024

Sponsor / Collaborator-

NCT04769193 / Unknown statusNot Applicable

A Clinical Trial Evaluating the Efficacy of a Skin Cream Targeting Dermal Fat in Improving the Skin Elasticity of Healthy Volunteers

A Clinical Trial Evaluating Efficacy of a Skin Cream Targeting Dermal Fat in Improving the Skin Elasticity of Healthy Volunteers.

Start Date27 Jan 2021

Sponsor / Collaborator-

NCT05610878 / RecruitingPhase 1IIT

Supplementation of Autologous Fat Grafts With Curcumin Preconditioned Adipose-Derived Stem Cells in the Treatment of Facial Contour Deformities

The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting to correct facial contour deformities that cause aesthetic complications in patients.

Start Date20 Nov 2020

Sponsor / Collaborator

University of the Punjab

[+3]

100 Clinical Results associated with Facial Hemiatrophy

100 Translational Medicine associated with Facial Hemiatrophy

0 Patents (Medical) associated with Facial Hemiatrophy

1,670

Literatures (Medical) associated with Facial Hemiatrophy

01 Dec 2024·Radiology Case Reports

Parry Romberg syndrome: A case report

Article

Author: Twum, Kwasi Adjepong ; Ankomah, Kwasi ; Amankwa, Adu Tutu ; Otoo, Obed Kojo ; Ashley, Godwin ; Afreh, Yaa Achiaa

Parry Romberg syndrome (PRS) is a rare self-limiting disease, typically occurring in children and young adults, that causes slow progressive atrophy of one-half of the face. It primarily affects the subcutaneous tissue and skin with some cases exhibiting deeper extension to glandular, osseous and muscular structures. Neurologic and ocular involvement is variable. Neuroimaging with computed tomography (CT) scan aids in demonstrating radiological features, assessing disease severity, and detecting neurological and ocular complications. We present a severe case of PRS in a 25-year-old female with right-sided facial asymmetry, diagnosed based on medical history, clinical examination and head CT scan findings.

24 Oct 2024·Clinical and Experimental Dermatology

Parry–Romberg syndrome following COVID-19 vaccination

Article

Author: De Caux, Deborah ; Akel, Randa

Parry–Romberg syndrome is an uncommon disorder characterized by hemifacial atrophy of the skin. We present an unusual case of COVID-19 vaccine-induced Parry–Romberg syndrome. To our knowledge, no previous cases have been reported.

24 Oct 2024·Clinical and Experimental Dermatology

A retrospective study of adult patients with Parry–Romberg syndrome

Article

Author: Sandler, Mykayla ; Fedeles, Flavia ; Shah, Nishi ; Tiao, Janice

Parry–Romberg syndrome (PRS), also known as progressive hemifacial atrophy, is characterized by atrophy of the skin and subcutaneous tissue, including muscle, bone and cartilage. PRS is a clinical diagnosis, although supportive imaging and histology may be obtained. We present a case series of 10 adult patients with a diagnosis of PRS seen at Massachusetts General Hospital and Brigham and Women’s Hospital from 2000 to 2021. Nine of 10 patients were women, with a mean (SD) age at onset of 27.3 (12.1) years and a mean (SD) of 12.4 (7.8) years between disease onset and diagnosis. Of the 10 patients, 4 had biopsies with supportive histopathology findings and 7 had positive imaging findings. Patients typically received both medical and surgical treatments.

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Facial Hemiatrophy

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