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Last update 23 Jan 2025

Facial Hemiatrophy

Last update 23 Jan 2025

Basic Info

Synonyms

ATROPHY, HEMIFACIAL, ROMBERG, Atrophies, Hemifacial, Atrophies, Progressive Hemifacial

+ [111]

Introduction

A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.

Drugs associated with Facial Hemiatrophy

Mesenchymal stem cell therapy (K-STEMCELL)

Target-

Mechanism

Cartilage replacements [+3]

Active Org.

R Bio Co., Ltd.

Originator Org.

R Bio Co., Ltd.

Active Indication

Osteoarthritis, Knee [+1]

Inactive Indication

Brain Infarction [+11]

Drug Highest PhasePhase 3

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

VascoStem

Target-

Mechanism-

Active Org.

R Bio Co., Ltd.

Originator Org.

R Bio Co., Ltd.

Active Indication

Facial Hemiatrophy [+1]

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Facial Hemiatrophy

ChiCTR2400081791

/ RecruitingNot ApplicableIIT

Quantitative Analysis of Tissue Defects in Progressive Hemifacial Atrophy Based on Facial Anatomical Zone

Start Date12 Mar 2024

Sponsor / Collaborator-

NCT04769193

/ Unknown statusNot Applicable

A Clinical Trial Evaluating the Efficacy of a Skin Cream Targeting Dermal Fat in Improving the Skin Elasticity of Healthy Volunteers

A Clinical Trial Evaluating Efficacy of a Skin Cream Targeting Dermal Fat in Improving the Skin Elasticity of Healthy Volunteers.

Start Date27 Jan 2021

Sponsor / Collaborator-

NCT05610878

/ RecruitingPhase 1IIT

Supplementation of Autologous Fat Grafts with Curcumin Preconditioned Adipose-Derived Stem Cells in the Treatment of Facial Contour Deformities

The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting to correct facial contour deformities that cause aesthetic complications in patients.

Start Date20 Nov 2020

Sponsor / Collaborator

University of the Punjab

[+3]

100 Clinical Results associated with Facial Hemiatrophy

100 Translational Medicine associated with Facial Hemiatrophy

0 Patents (Medical) associated with Facial Hemiatrophy

1,692

Literatures (Medical) associated with Facial Hemiatrophy

01 Mar 2025·Journal of Behavior Therapy and Experimental Psychiatry

Joint attention effect on irrelevant stimuli resistance in high functional autism and neurotypical adults

Article

Author: Antea, D 'Andrea ; Mauro, Pettorruso ; Giovanni, Martinotti ; Franca, Ceci ; Rosalia, Di Matteo ; Riccardo, Alessandrelli ; Marcella, Brunetti

BACKGROUND AND OBJECTIVESClinical practice reveals that individuals with autism characterized by the absence of cognitive impairment (High Functioning Autism-HFA) show difficulty in sharing attention with unfamiliar people. We hypothesized that this difficulty could affect cognitive control by selectively impairing stimulus-encoding or response-selection.METHODSTwenty-one HFA and 23 neurotypical adults were involved in a two-phase study. The first phase was performed at home, through an online link; the second one was held four months later in our laboratory in the presence of two experimenters. A letter-flanker task was administered in both phases. In the Stimulus-Response (SR) conflict condition, the target and flankers were assigned to the same/different response keys. In the Stimulus-Stimulus (SS) conflict condition, the target and flankers were perceptually similar/dissimilar. Two mixed-ANOVAs were conducted on response times and accuracy with Phases (Home vs Lab), Groups (HFA, Neurotypical), SR conditions (congruent, incongruent, neutral) and SS conditions (congruent, incongruent) as factors.RESULTSResults show that only HFAs' inhibition ability was negatively affected by the experimenters' presence compared to when they were alone, by reducing accuracy when dealing with an SS conflict.LIMITATIONSThe differences between the home-phase and lab-phase sessions require further elaboration to understanding the nature of social interaction during the lab session.CONCLUSIONSThese results suggest that, for HFA, the "at home" context, free from social and emotional pressure, allowed them to emphasize their detail-focused cognitive style.

02 Jan 2025·International Journal of Neuroscience

Recurrent cryptogenic strokes in a young female as a novel presentation of Parry Romberg syndrome: a case report and review

Article

Author: Valaparla, Vijaya Lakshmi ; Li, Xiangping ; Patel, Anand Vilaschandra ; Patel, Chilvana ; Lobaina, Milena

INTRODUCTIONParry Romberg Syndrome (PRS) is a less common genetic condition presenting with progressive hemifacial atrophy involving skin, underlying connective tissue, muscle and facial bone. Neurological manifestations include seizures, headaches, deafness and trigeminal neuralgia refractory to medications, while stroke is a less common presentation.MATERIALS AND METHODSA 43-year-old right-handed female with previous history of Lower Motor Neuron (LMN) type facial palsy, seizure disorder and linear scleroderma, presented to our clinic with recurrent cryptogenic strokes. She developed progressive hemifacial atrophy on the left side and left eye ectropion and was eventually diagnosed with rare Parry Romberg Syndrome.RESULTSPatient underwent extensive work up for stroke to rule out etiologies like hyperlipidemia, diabetes, lupus and vasculitis. Peripheral labs for inflammatory markers and Cerebrospinal fluid (CSF) studies were unremarkable. Brain imaging at different points in time showed progressive atrophy of brain parenchyma, overlying bone, connective tissue and facial muscles on the left side. Central Nervous System (CNS) vessel imaging and diagnostic cerebral angiogram was unremarkable.CONCLUSIONThis novel case underscores the potential CNS involvement in PRS, which is a rare disease entity. Neurological manifestations are not uncommon, including stroke. Further research is needed to understand the mechanisms of stroke in this rare disease process, that could help develop potential therapeutic targets.

01 Dec 2024·Radiology Case Reports

Parry Romberg syndrome: A case report

Article

Author: Twum, Kwasi Adjepong ; Ankomah, Kwasi ; Amankwa, Adu Tutu ; Otoo, Obed Kojo ; Ashley, Godwin ; Afreh, Yaa Achiaa

Parry Romberg syndrome (PRS) is a rare self-limiting disease, typically occurring in children and young adults, that causes slow progressive atrophy of one-half of the face. It primarily affects the subcutaneous tissue and skin with some cases exhibiting deeper extension to glandular, osseous and muscular structures. Neurologic and ocular involvement is variable. Neuroimaging with computed tomography (CT) scan aids in demonstrating radiological features, assessing disease severity, and detecting neurological and ocular complications. We present a severe case of PRS in a 25-year-old female with right-sided facial asymmetry, diagnosed based on medical history, clinical examination and head CT scan findings.

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