Request Demo

Last update 08 May 2025

Facial Hemiatrophy

Last update 08 May 2025

Basic Info

Synonyms

ATROPHY, HEMIFACIAL, ROMBERG, Atrophies, Hemifacial, Atrophies, Progressive Hemifacial

+ [111]

Introduction

A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.

Drugs associated with Facial Hemiatrophy

VascoStem

Target-

Mechanism-

Active Org.

R Bio Co., Ltd.

Originator Org.

R Bio Co., Ltd.

Active Indication

Facial Hemiatrophy [+1]

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Mesenchymal stem cell therapy (K-STEMCELL)

Target-

Mechanism

Cartilage replacements [+3]

Active Org.

R Bio Co., Ltd.

Originator Org.

R Bio Co., Ltd.

Active Indication

Alzheimer Disease

Inactive Indication

Brain Infarction [+12]

Drug Highest PhasePhase 1/2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Facial Hemiatrophy

ChiCTR2400081791

/ RecruitingNot ApplicableIIT

Quantitative Analysis of Tissue Defects in Progressive Hemifacial Atrophy Based on Facial Anatomical Zone

Start Date12 Mar 2024

Sponsor / Collaborator-

NCT04769193

/ Unknown statusNot Applicable

A Clinical Trial Evaluating the Efficacy of a Skin Cream Targeting Dermal Fat in Improving the Skin Elasticity of Healthy Volunteers

A Clinical Trial Evaluating Efficacy of a Skin Cream Targeting Dermal Fat in Improving the Skin Elasticity of Healthy Volunteers.

Start Date27 Jan 2021

Sponsor / Collaborator-

NCT05610878

/ RecruitingPhase 1IIT

Supplementation of Autologous Fat Grafts with Curcumin Preconditioned Adipose-Derived Stem Cells in the Treatment of Facial Contour Deformities

The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting to correct facial contour deformities that cause aesthetic complications in patients.

Start Date20 Nov 2020

Sponsor / Collaborator

University of the Punjab

[+3]

100 Clinical Results associated with Facial Hemiatrophy

100 Translational Medicine associated with Facial Hemiatrophy

0 Patents (Medical) associated with Facial Hemiatrophy

1,390

Literatures (Medical) associated with Facial Hemiatrophy

01 Apr 2025·Journal of Cranio-Maxillofacial Surgery

Alloplastic implants for skeletal augmentation in Parry-Romberg syndrome: A systematic review

Review

Author: Kauke-Navarro, Martin ; Knoedler, Leonard ; Diatta, Fortunay ; Knoedler, Samuel ; Safi, Ali-Farid ; Klimitz, Felix J

Parry-Romberg syndrome (PRS) is a rare disorder characterized by progressive hemifacial atrophy affecting soft tissue and, in severe cases, bone. Reconstructive surgery is commonly used to manage PRS-related facial deformities. This systematic review assesses the current literature on alloplastic implants for facial reconstruction in PRS. Following PRISMA guidelines, we conducted a systematic review across MEDLINE, Google Scholar, and Cochrane databases, including English-language studies on PRS managed with alloplastic implants. Eleven studies, including 74 PRS patients (age range 12-45, mean 22.3), were analyzed. Most patients received off-the-shelf implants, with a single case using a 3D-modeled titanium implant. Implants, often adjunctive to free flap-based soft tissue augmentation, fat grafting, or orthognathic surgery, were typically placed in the malar, mandibular, or mental regions, with porous polyethylene (Medpor) being the most frequently used material. Complications were minimal, with infections (n = 2) and one aesthetic issue requiring removal (follow-up range: six months to 13 years; mean 39 months). Alloplastic implants effectively restore facial symmetry in PRS, commonly alongside soft tissue reconstruction. Future studies on custom-designed implants are warranted to enhance treatment consistency and long-term outcomes.

21 Mar 2025·Cureus

Treatment of Facial Asymmetry Caused by Parry-Romberg Syndrome Using Fat Transfer

Article

Author: Echevarria Cruz, Evelyn C ; Moenster, Jamie M ; Heyer, Brooke E

Parry-Romberg syndrome (PRS) is a rare craniofacial disorder marked by progressive unilateral facial atrophy. This case report presents a unique instance of PRS presenting in a 52-year-old female who was diagnosed at age 47 as the syndrome's usual onset is during the first two decades of life. The patient exhibited severe soft-tissue atrophy on the right side of the face, classified as type 3 PRS, along with associated symptoms such as headaches and a history of depression. The primary aesthetic intervention involved fat transfer (FT) to restore facial symmetry and contour. Postoperative outcomes improved facial aesthetics, though some volume loss was noted at the three-month follow-up. This case highlights the potential of FT as an effective and minimally invasive treatment for severe PRS. It emphasizes the importance of personalized treatment strategies and the need for further research into the long-term management of PRS, particularly in late-diagnosed cases. Further studies are needed to optimize fat grafting techniques and assess long-term outcomes in PRS management.

01 Mar 2025·Journal of Craniofacial Surgery

The Correlation Between Progressive Hemifacial Atrophy and Mandibular Hyaluronic Acid Injection

Article

Author: Zhuang, Jun ; Liang, Yutong ; Yao, Jiaqi ; Zhang, Ziming ; Hu, Jintian ; Su, Xueshang ; Qin, Mengzhe

Hyaluronic acid filler treatment is increasingly prevalent in the realm of plastic surgery, serving to correct a range of facial changes resulting from aging. Nevertheless, with its expanded application, an uptick in complications has been observed. This article reported a 30-year-old female patient who received chin hyaluronic acid filler treatment 5 years ago started experiencing atrophy and progressive deterioration at the injection site a year ago. Currently, she presents with a pronounced depression beneath the left corner of her mouth, along with changes in skin tone and scarring. The patient exhibited progressive hemifacial atrophy within the region that had been injected with hyaluronic acid. Progressive hemifacial atrophy at the injection site may be a novel adverse effect associated with the injection of fillers, and it is important to be vigilant about this possibility.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Facial Hemiatrophy

Basic Info

Related

Analysis