Trigeminal Nerve Diseases

More than one billion people worldwide live with migraine,i and the World Health Organization classifies migraine as the second leading cause of disability in the world.ii KIRKLAND, QC, April 4, 2024 /CNW/ - NURTEC ODT® (rimegepant) is now available in Canada for use in the acute treatment of migraine, with or without aura in adults older than 18 years of age.iii NURTEC is an orally disintegrating calcitonin gene-related peptide (CGRP) receptor antagonist tablet. It was approved by Health Canada on December 1, 2023. Classified as one of the 10 most disabling medical illnesses in the world,iv migraine is a brain disease characterized by attacks that last from four to 72 hours with multiple symptoms including, pulsating moderate to severe headache, sensitivity to light and sound, nausea and sometimes vomiting, as well as cognitive fogginess, amongst other symptoms.v "Migraine is a common, disabling brain disease, and for those living with migraine, effective therapy can take years to be found," said Dr. Christine Lay, Professor of Neurology and Founding Director of the Headache Program at the University of Toronto. "It is an exciting time for Canadians to now have another targeted, migraine specific therapy in their management toolbox." An estimated 4.5 million Canadians suffer from migraine with one in four households having someone affected by the disease.vi In Canada, migraine is a leading cause of years lived with disability among those aged 15 to 49 years. vii "Migraine symptoms are complex and may last for several days. People living with migraine are looking for timely and equitable access to new options to effectively manage this highly debilitating disease," said Wendy Gerhart from Migraine Canada. "We are excited for new treatments to help advance migraine care, which is often overlooked, underdiagnosed, and undertreated." "Pfizer Canada is proud to bring this new therapy to Canadians impacted by migraine," said Andréa Mueller, Primary Care Portfolio Lead, Pfizer Canada. "Pfizer has a long-standing legacy in managing neurological conditions, and we are proud to build on our commitment in this area with our work in the treatment of migraine." About Migraine Migraine is the third most prevalent illness in the world,viii affecting around 1.3 billion people globally.ix Migraine prevalence is highest during peak employment years.x In Canada, migraine is the third-leading cost driver for incremental productivity loss due to absenteeism and presenteeism.xi,xii While migraine affects all demographics, women are disproportionately impacted by this brain disease.xiii About NURTEC ODT® NURTEC ODT targets a key component of migraine by reversibly blocking calcitonin gene-related peptide (CGRP) receptors. CGRP is increased during a migraine attack, promotes neurogenic inflammation, dilates blood vessels and is involved in nociceptor signaling. CGRP receptor antagonists work by reversibly blocking CGRP receptors, thereby inhibiting the biologic activity of the endogenous CGRP neuropeptide. CGRP receptors are a key contributor to the trigeminal nerve pain and inflammation of migraine.xiv About Pfizer Canada Pfizer Canada ULC is the Canadian operation of Pfizer Inc., one of the world's leading biopharmaceutical companies. At Pfizer, we apply science and our global resources to bring therapies to people that help extend and improve their lives. We strive to set the standard for quality, safety, and value in the discovery, development, and manufacture of health care products. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments, and cures that challenge the most feared diseases of our time. Consistent with our responsibility as one of the world's premier innovative biopharmaceutical companies, we collaborate with health care providers, governments, and local communities to support and expand access to reliable, affordable health care around the world. For 175 years, Pfizer has worked to make a difference for all who rely on us. Global headquarters are located in New York City, where the company was founded in 1849. Pfizer's Canadian footprint includes its headquarters in Kirkland, Quebec and a manufacturing site in Brandon, Manitoba. To learn more about Pfizer Canada, visit pfizer.ca or you can follow us on LinkedIn, Facebook, X, Instagram or YouTube. SOURCE Pfizer Canada Inc.

Findings presented by Agendia collaborators at the European Breast Cancer Conference indicate that the Research Use Only ImPrint test can predict response and non-response to common immunotherapy regimens IRVINE, Calif. & AMSTERDAM--(BUSINESS WIRE)-- Agendia®, Inc. today announced new data from the I-SPY 2 trial showcasing its ImPrint signature for patients with triple negative (TN) breast cancer, shared by I-SPY 2 researchers in an oral presentation at the 14th European Breast Cancer Conference in Milan, Italy. Agendia has been in partnership with Quantum Leap Healthcare Collaborative, the sponsors of the neoadjuvant biomarker-rich I-SPY 2 trial, since 2010. I-SPY 2 established a new benchmark for the efficacy of Phase 2 clinical trials and is widely regarded as the pioneer of the platform trial. The presentation, titled Immune subtyping in the Response Predictive Subtypes (RPS) identifies a subset of triple negative (TN) early-stage breast cancer patients with a very low likelihood of response to neoadjuvant immunotherapy (IO): results from 5 IO arms of the I-SPY 2 TRIAL (van ’t Veer, L, J., et al.), investigates the utility of a refined version of ImPrint, called ImPrintTN, designed to provide more accurate predictions to response to common immunotherapy (IO) regimens for TN patients. The study, examining the responses of patients who received a variety of IO regimens in the I-SPY 2 trial, showed that ImPrintTN predicts both response and non-response, suggesting that the test may help inform prioritization of IO versus other treatments for TN patients to best balance likely benefit versus the risk of the serious adverse effects that often accompany IO. “Many immunotherapy treatments can have difficult, severe adverse side effects on patients that can outweigh the benefit of the treatment. It is imperative to understand what a patient’s response will be to these therapies prior to using them,” said Laura van ‘t Veer, Professor of Laboratory Medicine, Co-leader of the Breast Oncology Program and Director of Applied Genomics at the Helen Diller Family Comprehensive Cancer Center, University of California, and Co-Founder of Agendia, Inc. “The data we are presenting at the European Breast Cancer Conference demonstrates ImPrintTN’s predictive ability to help patients with triple negative breast cancer avoid immunotherapy if they are not likely to benefit – these insights are critical and can be used to inform alternative treatment strategies and customize our approach to meet the needs of each patient’s cancer diagnosis.” ImPrint was developed to be used in the clinic to predict the likelihood of patients responding to immunotherapies by looking at the biology of the patient’s tumor. Agendia currently holds an FDA Investigational Device Exempt status for the ImPrint signature, allowing for its use in the I-SPY 2 trial and for other ongoing research with collaborators. About the I-SPY TRIALs The I-SPY TRIAL (Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And moLecular analysis 2) (I-SPY 2 TRIAL) was designed to rapidly screen promising experimental treatments and identify those most effective in specific patient subgroups based on molecular characteristics (biomarker signatures). The trial is a unique collaborative effort by a consortium that includes the Food and Drug Administration (FDA), industry, patient advocates, philanthropic sponsors, and clinicians from over 40 major U.S. cancer research centers. Under the terms of the collaboration agreement, Quantum Leap Healthcare Collaborative is the trial sponsor and manages all study operations. For more information, visit . About Quantum Leap Healthcare Collaborative™ The I-SPY 2 TRIAL ( ), is sponsored by Quantum Leap Healthcare Collaborative™, a 501c (3) charitable organization. Quantum Leap is dedicated to integrating high-impact clinical research with patient care to improve and save lives. By bridging the gap between research and clinical care, Quantum Leap works in collaboration with patients, medical researchers at the University of California, other academic centers nationwide, healthcare innovators, and stakeholders--to accelerate learning in medicine, improve the delivery of healthcare, create better outcomes, and increase the quality of life. Our goal is to improve and save lives. About Agendia Agendia is a leading provider of innovative solutions in the field of precision oncology. With a focus on early-stage breast cancer, Agendia offers reliable biological insights that inform personalized treatment decisions for patients and their care teams. Their advanced genomic assays, MammaPrint® + BluePrint®, enable clinicians to quickly identify the most effective treatment plan, minimizing the risk of both under- and over-treatment. Founded in 2003 in Amsterdam, Agendia is headquartered in Irvine, California with a state-of-the-art laboratory facility. Led by world-renowned scientists and oncologists, Agendia is committed to advancing genomic insights through ongoing research. This includes the notable FLEX Study– the world's largest whole transcriptome Real-World Evidence-based Breast Cancer database which aims to revolutionize precision in breast cancer management. With cutting-edge technology, research and innovation, Agendia strives to shape the future of precision oncology and make a significant impact in the fight against breast cancer. View source version on businesswire.com: Contacts Media Terri Clevenger ICR Westwicke Healthcare PR Tel: 203.856.4326 Terri.Clevenger@Westwicke.com Source: Agendia, Inc. 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NORTHFIELD, Ill., March 1, 2024 /PRNewswire/ -- Prominently featured in The Inner Circle, Brian McDonagh, MD is acknowledged as a Pinnacle Lifetime Member for his contributions to the Medical field. Dr. Brian McDonagh, MD, is a renowned medical professional known for his exceptional contributions to the field of medicine, particularly in the treatment of Multiple Sclerosis (MS) and peripheral neuropathy. As the founder of Vein Clinics of America, Dr. McDonagh has developed innovative treatment protocols that have brought hope and relief to countless patients. The neurologist is celebrated for his innovative medical breakthroughs, which have transformed the lives of patients suffering from MS, Crohn's Disease, and Peripheral Neuropathy. His pioneering work has resulted in the development of highly effective treatments that have rapidly alleviated symptoms and improved the quality of life for numerous individuals. A staunch proponent for Alternative Medicine, Dr. McDonagh is pleased to be recognized for his contributions to the field of neurology. Evident in his work, the doctor notes that he is concerned that the body of neurology will be left behind by Alternative Medicine, of which he has had excellent progress for MS, Migraines, Trigeminal Neuralia, Carpal Tunnel Syndrome, and a host of neuropathies. Dr. McDonagh recommends that his peers examine the work of his mentor, John Lyftogt, MD, in New Zealand, who is considered the father of PIT (Perineural injection treatment). His influence on the doctor has played a major role in shaping his medical journey. The doctor's journey to medical excellence began at University College Dublin, where he earned his Bachelor's degree and MD. His unwavering commitment to advancing medical knowledge led him to pursue a residency at Tucson Hospital in Detroit, where he honed his skills and expertise. Reflecting on his inspiration to contribute to the field of neurology, Dr. McDonagh extends his heartfelt gratitude to his four children and eight grandchildren for their boundless love and support throughout his medical career. Their unwavering encouragement has been a source of strength and inspiration. Dr. McDonagh's commitment to his patients' well-being and his contributions to medical advancements have undoubtedly earned him recognition within the medical community. His philosophy revolves around treating patients like family. His compassionate and personalized care approach ensures that patients receive the highest level of attention and support. Dr. McDonagh's future projections encompass a commitment to delivering continuous, exceptional care to his patients. His dedication to advancing medical knowledge and improving patient outcomes remains unwavering. Aside from his professional pursuits, Dr. McDonagh finds relaxation in word games, enjoys reading, and has an appreciation for the beauty of opera. These interests reflect his multifaceted approach to life. Contact: Katherine Green, 516-825-5634, [email protected] SOURCE The Inner Circle