Drug Type Synthetic peptide |
Synonyms CardioTREM, Motrem, TREM-like-transcript-1-derived-peptide + [1] |
Target |
Action inhibitors |
Mechanism TREM1 inhibitors(Triggering receptor expressed on myeloid cells 1 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC54H82N14O22S2 |
InChIKeyHZQYFECPKQJXFX-DAHMAOPXSA-N |
CAS Registry2014384-91-7 |
Start Date23 Sep 2020 |
Sponsor / Collaborator |
Start Date12 Jun 2020 |
Sponsor / Collaborator- |
Start Date13 Nov 2019 |
Sponsor / Collaborator |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
COVID-19 | Phase 3 | Belgium | 06 Jul 2020 | |
Shock, Septic | Phase 3 | Netherlands | 03 Jul 2017 | |
Myocardial Infarction | Phase 3 | France | - | |
Shock, Septic | Phase 2 | Spain | 03 Jul 2017 | |
Shock, Septic | Phase 2 | Belgium | 03 Jul 2017 | |
Shock, Septic | Phase 2 | France | 03 Jul 2017 |
Study | Phase | Population | Analyzed Enrollment | Group | Results | Evaluation | Publication Date |
---|
Phase 2 | 355 | (egnsekzkjd) = fwpkqxjkhc tyelqbbgmm (iqdivfolrt ) | Negative | 01 Oct 2023 | |||
(egnsekzkjd) = tohgolknfu tyelqbbgmm (iqdivfolrt ) | |||||||
Phase 2 | 220 | uhixowslxe(sfaripclqq): odds ratio = 1.79 (95% CI, 1.02 - 3.14), P-Value = 0.043 | Positive | 01 Jun 2023 | |||
Placebo | |||||||
Phase 2 | 220 | xreqabdxkr(hfcibkgqch): P-Value = 0.040 View more | Positive | 25 Oct 2022 | |||
Placebo | |||||||
Phase 2 | - | (nuvizjevew) = the benefit of nangibotide high dose treatment versus placebo was clinically and statistically significant at higher concentrations of sTREM-1, representing about 50% of the study population ivwpuwmogx (hwvitzclpy ) | Positive | 13 Oct 2022 | |||
Standard of Care | |||||||
Phase 1 | 27 | mibpoynprt(xoqkoezxcf) = There were only few adverse events and they were mild in severity and considered unrelated to treatment kymomdzkvj (oielzgvrnb ) | - | 01 Oct 2018 |