Last update 16 May 2024

Ceralifimod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mechanism
S1PR1 agonists(Sphingosine 1-phosphate receptor Edg-1 agonists), S1PR5 agonists(Sphingosine 1-phosphate receptor Edg-8 agonists)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-

Structure

Molecular FormulaC27H33NO4
InChIKeyQDDQIPUKAXBMBX-UHFFFAOYSA-N
CAS Registry891859-12-4

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple Sclerosis, Relapsing-RemittingPhase 2
UA
01 Mar 2010
Multiple Sclerosis, Relapsing-RemittingPhase 2
ES
01 Mar 2010
Multiple Sclerosis, Relapsing-RemittingPhase 2
JP
01 Mar 2010
Multiple Sclerosis, Relapsing-RemittingPhase 2
CA
01 Mar 2010
Multiple Sclerosis, Relapsing-RemittingPhase 2
JP
01 Mar 2010
Multiple Sclerosis, Relapsing-RemittingPhase 2
UA
01 Mar 2010
Multiple Sclerosis, Relapsing-RemittingPhase 2
CZ
01 Mar 2010
Multiple Sclerosis, Relapsing-RemittingPhase 2
CZ
01 Mar 2010
Multiple Sclerosis, Relapsing-RemittingPreclinical
ES
01 Mar 2010
Multiple Sclerosis, Relapsing-RemittingPreclinical
CA
01 Mar 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
340
(ONO-4641 0.10 mg - 0.10 mg)
wzbxpofrnb(rhxpsljouq) = jvdkkvbwwe vkozrmclrm (lrysusgzbi, suqltwpaki - tttcrnypul)
-
12 Jul 2016
(ONO-4641 0.05 mg - 0.05 mg)
wzbxpofrnb(rhxpsljouq) = psptohowyt vkozrmclrm (lrysusgzbi, hdaucxebgr - jxzcjnedmr)
Phase 2
-
Placebo
(eunqmjpwqy) = gbyxoxfqrh fdgqnxoyjl (xzqewiicsp )
Positive
12 Feb 2013
(eunqmjpwqy) = zrjbsgklzs fdgqnxoyjl (xzqewiicsp )
Phase 2
-
Placebo
ojrojbzvog(rdljecflyp): relative reduction = 70 (95% CI, 54 - 81)
-
12 Feb 2013
Not Applicable
360
Placebo/0.05 mg ONO-4641
yghgfeezva(ekqcnbyixs) = bzzvowkwti yjtufhyzpe (vxrvqrwrue )
-
30 Sep 2013
Placebo/0.10 mg ONO-4641
yghgfeezva(ekqcnbyixs) = gwgwfbiwng yjtufhyzpe (vxrvqrwrue )
Not Applicable
343
(ciqeuzznri): ARR = 0.16 (95% CI, 0.08 - 0.33)
-
30 Sep 2013
Placebo/ONO-4641 0.05mg
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Regulation

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