Drug Type Small molecule drug |
Synonyms |
Target |
Mechanism S1PR1 agonists(Sphingosine 1-phosphate receptor Edg-1 agonists), S1PR5 agonists(Sphingosine 1-phosphate receptor Edg-8 agonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC27H33NO4 |
InChIKeyQDDQIPUKAXBMBX-UHFFFAOYSA-N |
CAS Registry891859-12-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Multiple Sclerosis, Relapsing-Remitting | Phase 2 | UA | 01 Mar 2010 | |
Multiple Sclerosis, Relapsing-Remitting | Phase 2 | ES | 01 Mar 2010 | |
Multiple Sclerosis, Relapsing-Remitting | Phase 2 | JP | 01 Mar 2010 | |
Multiple Sclerosis, Relapsing-Remitting | Phase 2 | CA | 01 Mar 2010 | |
Multiple Sclerosis, Relapsing-Remitting | Phase 2 | JP | 01 Mar 2010 | |
Multiple Sclerosis, Relapsing-Remitting | Phase 2 | UA | 01 Mar 2010 | |
Multiple Sclerosis, Relapsing-Remitting | Phase 2 | CZ | 01 Mar 2010 | |
Multiple Sclerosis, Relapsing-Remitting | Phase 2 | CZ | 01 Mar 2010 | |
Multiple Sclerosis, Relapsing-Remitting | Preclinical | ES | 01 Mar 2010 | |
Multiple Sclerosis, Relapsing-Remitting | Preclinical | CA | 01 Mar 2010 |
Phase 2 | 340 | (ONO-4641 0.10 mg - 0.10 mg) | wzbxpofrnb(rhxpsljouq) = jvdkkvbwwe vkozrmclrm (lrysusgzbi, suqltwpaki - tttcrnypul) View more | - | 12 Jul 2016 | ||
(ONO-4641 0.05 mg - 0.05 mg) | wzbxpofrnb(rhxpsljouq) = psptohowyt vkozrmclrm (lrysusgzbi, hdaucxebgr - jxzcjnedmr) View more | ||||||
Phase 2 | - | Placebo | (eunqmjpwqy) = gbyxoxfqrh fdgqnxoyjl (xzqewiicsp ) View more | Positive | 12 Feb 2013 | ||
(eunqmjpwqy) = zrjbsgklzs fdgqnxoyjl (xzqewiicsp ) View more | |||||||
Phase 2 | - | Placebo | ojrojbzvog(rdljecflyp): relative reduction = 70 (95% CI, 54 - 81) | - | 12 Feb 2013 | ||
Not Applicable | 360 | Placebo/0.05 mg ONO-4641 | yghgfeezva(ekqcnbyixs) = bzzvowkwti yjtufhyzpe (vxrvqrwrue ) | - | 30 Sep 2013 | ||
Placebo/0.10 mg ONO-4641 | yghgfeezva(ekqcnbyixs) = gwgwfbiwng yjtufhyzpe (vxrvqrwrue ) | ||||||
Not Applicable | 343 | (ciqeuzznri): ARR = 0.16 (95% CI, 0.08 - 0.33) | - | 30 Sep 2013 | |||
Placebo/ONO-4641 0.05mg |