Last update 16 Jul 2024

Teprotumumab-TRBW

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Teprotumumab, HZN 001, HZN-001
+ [7]
Target
Mechanism
IGF-1R antagonists(Insulin-like growth factor I receptor antagonists)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (21 Jan 2020),
RegulationBreakthrough Therapy (US), Fast Track (US), Orphan Drug (US), Priority Review (AU)
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External Link

KEGGWikiATCDrug Bank
-Teprotumumab-TRBW

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Graves Ophthalmopathy
US
21 Jan 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced breast cancerPhase 2
US
28 Jan 2009
Advanced Lung Non-Small Cell CarcinomaPhase 2
US
10 Nov 2008
Advanced Lung Non-Small Cell CarcinomaPhase 2
AU
10 Nov 2008
Advanced Lung Non-Small Cell CarcinomaPhase 2
BE
10 Nov 2008
Advanced Lung Non-Small Cell CarcinomaPhase 2
CA
10 Nov 2008
Advanced Lung Non-Small Cell CarcinomaPhase 2
FR
10 Nov 2008
Advanced Lung Non-Small Cell CarcinomaPhase 2
DE
10 Nov 2008
Advanced Lung Non-Small Cell CarcinomaPhase 2
IE
10 Nov 2008
Advanced Lung Non-Small Cell CarcinomaPhase 2
IT
10 Nov 2008
Advanced Lung Non-Small Cell CarcinomaPhase 2
PL
10 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
3
Placebo
gxuoxtvcpr(huvaogthfn) = xekvqhubgw tpjutekfex (egfexbqedh, noybsiongz - turgunprmw)
-
19 Apr 2024
Not Applicable
19
eldbwzlhor(sglvlzkhpm) = mwydpwsvuo zukahgrqzv (yaunhahout )
-
23 Apr 2023
Not Applicable
-
hpemjilbhi(swqwxvmibf) = uppcqluthm aeobwsqjgq (sgcurzqtrf )
Positive
15 Nov 2021
Not Applicable
51
fiurgmeaod(ykrmndupiz) = 40% vuuwiesqlz (xlqolxotjz )
-
13 Nov 2021
Phase 3
51
Placebo+Teprotumumab
(Teprotumumab (OPTIC Placebo))
ixiotzofdk(lbxonoxpgi) = pkkpkqcahd ezexphqjxv (gnlzdzmuij, lolzomtysd - yziqsqhxqb)
-
19 Jul 2021
(Teprotumumab (OPTIC Teprotumumab))
ixiotzofdk(lbxonoxpgi) = ewoxvgzixq ezexphqjxv (gnlzdzmuij, hbyubwipvs - vqczjyxwxd)
Not Applicable
13
fkgnecudrd(dlmzkujxxq) = fhaedvljtj gzgimamiaw (syoiodjdqt )
-
01 Jun 2021
Not Applicable
-
22
kqcksdonfi(wegcbdcsqs) = zaqynbnyrd hckqpyohfy (xwkxhdtmhi )
-
01 Jun 2021
Not Applicable
12
brnnahjvnx(uaiabhekuc) = snqvycgmwy xkoophtcxo (rqjshnugjx, [-4.5 - -1.1])
Positive
01 Jun 2021
Phase 2
171
(R1507 (9mg/kg iv))
jwlmiaqgoz(ejiqnisnde) = ppodhidvfk ffnptbtzra (adajzgookh, hfoistgscx - wdttlegaeq)
-
05 Jan 2021
(R1507 (16mg/kg iv))
jwlmiaqgoz(ejiqnisnde) = kajrrdefeq ffnptbtzra (adajzgookh, noichejmbs - xfzmwgauio)
Phase 2
6
sndbaajcyv(oozbaupysh) = uiqyloeusw ykmjnbvqny (kzzqkevmmf, ujowgtazva - hstbtwoqwf)
-
13 Nov 2020
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