Delving into the Latest Updates on Sodium Hypochlorite with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Canal, TEXANT, Yakulax

+ [3]

Target-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication

Disinfectants

Inactive Indication-

Originator Organization

SIOE Pharmaceutical Co., Ltd.

Active Organization

Bee Brand Medico Dental Co., Ltd.SIOE Pharmaceutical Co., Ltd.Yakuhan Pharmaceutical Co. Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

JP (14 Feb 2006),

Disinfectants

Regulation-

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Structure

Molecular FormulaClHNaO

InChIKeyKQPBSBAEBKRAAU-UHFFFAOYSA-N

CAS Registry7681-52-9

AbstractAimTo evaluate the 6‐year outcome of root canal treatment irrigated with 0.5% or 3% sodium hypochlorite (NaOCl).MethodologyThe baseline trial was designed as a quasi‐randomized clinical trial. Patients referred for root canal treatment to an endodontic specialist clinic were recruited to the study (n = 298). The concentration of NaOCl was allocated quasi‐randomized to 271 subjects (0.5% [n = 139], 3% [n = 132]). Bacterial sampling was performed immediately before root canal filling. Samples were cultured and evaluated as growth or no growth. Patients were invited to a clinical and radiological follow‐up >5 years postoperatively. The clinical outcome measurements were tooth survival, cumulative incidence of endodontic retreatments, patients' assessment of pain, clinical findings and radiological signs of apical periodontitis (AP).ResultsTooth survival was 85.6% in the 0.5% NaOCl group and 81.1% in the 3% NaOCl group (p = .45). There was no record of retreatment in 94.4% in the 0.5% NaOCl group and in 92.2% in the 3% NaOCl group (p = .76). The percentage of asymptomatic cases were 87.8% in the 0.5% group and 85.3% in the 3% NaOCl group (p = .81). Absence of clinical signs of AP was seen in 86.6% in the 0.5% NaOCl group and in 83.6% in the 3% NaOCl group (p = .80). Absence of radiological signs of AP was seen in 74.0% in the 0.5% NaOCl group and 64.1% in the 3% NaOCl group (p = .20). Subjects with positive culture before root filling reported subjective pain with a significantly higher frequency as compared to negative‐culture subjects (p = .014).ConclusionsThe use of 0.5% or 3% NaOCl for irrigation during root canal treatment resulted in similar clinical outcomes 5–7 years postoperatively. Persisting bacteria immediately before root filling may predict future episodes of subjective pain.

01 Dec 2024·Microbial Pathogenesis

The treatment of Enterococcus faecalis related root canal biofilms with phage therapy

Article

Author: Gül ZIRAMAN, Fatma ; Başak EROL, Hilal ; Ziraman, Fatma Gul ; Basak Erol, Hilal ; Gocmen, Damla ; KASKATEPE, Banu ; GOCMEN, Damla ; Kaskatepe, Banu

As one of the global concerns, antimicrobial resistance crisis increases the clinical importance of Enterococcus species. Enterococcus faecalis (E. faecalis) specifically penetrates the dentinal tubules and remains prevalent even after endodontic treatment. It has also biofilm forming character as well as the development of resistance to antibiotics. Sodium hypochlorite (NaOCl) is considered the gold standard among antibacterial washing solutions. However, due to its toxic effects, its usage limitations have led to the search for natural, non-toxic alternatives. Phages can be considered an important alternative because of their effects on specific bacteria. The objective of this study was to compare the effect of isolated active vB_Ef1 phage on the removal of E. faecalis biofilm in dentin, together and separately with the chemical irrigation solution NaOCl. As a result of study, the optimal NaOCl solution concentration to be applied with vB_Ef1 phage is 0.5 %, and the use of solution at this value reduces the biofilm mass by 84 %, reaching the highest biofilm mass reduction value. It was found that the combination of phage and NaOCl at appropriate concentrations had the strongest biofilm disruption effect.

01 Dec 2024·Environmental Pollution

Challenges in Raman spectroscopy of (micro)Plastics: The interfering role of colourants

Article

Author: Vanoirbeek, Jeroen A.J. ; Ronsmans, Steven ; Ghosh, Manosij ; Vanoirbeek, Jeroen A J ; Hoet, Peter H.M. ; Azari, Aala ; Hoet, Peter H M

Rising plastic consumption leads to widespread microplastic (MP) contamination. Raman spectroscopy is widely used for MP identification due to its ability to analyse particles as small as 1 μm. However, it faces challenges such as interference from pigments and additives. In this study, we aim to assess the accuracy of Raman micro-spectroscopy in identifying coloured plastic samples by applying various oxidative treatments to eliminate the possible interference effect caused by colourants associated with the sample. Standard and coloured microplastics were analysed using a Raman imaging microscope. Coloured plastics were treated with H₂O₂ 30%, Sodium hypochlorite 5%, and Fenton reagent ( H2O2 30% and Ferrous sulphate 0.2 M) for 24, 48, and 72 hours. The Raman spectra were acquired after treatment to assess the impact of the treatment procedure on the polymer identification. Our results revealed that colourants significantly impact Raman spectra by peak broadening and/or fluorescence effects, which reduces identification accuracy and match scores Red pigments particularly obscure polymer identification. Treatments like oxidation and Fenton's reagent showed limited effectiveness. Additives in plastic samples can affect the accuracy of polymer identification by the Raman spectroscopy technique. Common treatment procedures do not improve the accuracy of identification. In order to improve the reliability of Raman analysis, essential factors such as utilizing multiple excitation lasers and appropriate CCD detectors, establishing a comprehensive reference library of colourants and additives, and employing advanced techniques like time-gated Raman spectroscopy or Surface-Enhanced Raman Spectroscopy (SERS) should be considered.

100 Deals associated with Sodium Hypochlorite

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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Disinfectants	JP	SIOE Pharmaceutical Co., Ltd.	14 Feb 2006

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


IAS2008	Not Applicable	-	-	sodium hypochlorite (NaOCl) (Standard method)	poyyaclzbs(jmnszdagaf) = atelahwcav wzjzmrzfet (meonblvwul ) View more	-	01 Jan 2008
				sodium hypochlorite (NaOCl) (NaOCL)	poyyaclzbs(jmnszdagaf) = tbeubealjh wzjzmrzfet (meonblvwul ) View more