Last update 11 Jul 2024

Denileukin Diftitox

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
DAB389 interleukin-2, Denileukin, Denileukin difitox (genetical recombination) (JAN)
+ [18]
Target
Mechanism
IL2RA agonists(Interleukin-2 receptor alpha chain agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (05 Feb 1999),
RegulationAccelerated Approval (US), Orphan Drug (US), Orphan Drug (EU)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Peripheral T-Cell Lymphoma
JP
23 Mar 2021
Cutaneous T-Cell Lymphoma
US
05 Feb 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant melanoma stage IVPhase 2
US
22 Jun 2010
Secondary malignant neoplasm of pancreasPhase 2
US
01 Oct 2008
Metastatic melanomaPhase 2
US
23 Apr 2007
Chronic Lymphocytic LeukemiaPhase 2
US
01 Mar 2003
Chronic Lymphocytic LeukemiaPhase 2
AR
01 Mar 2003
Chronic Lymphocytic LeukemiaPhase 2
AU
01 Mar 2003
Chronic Lymphocytic LeukemiaPhase 2
BR
01 Mar 2003
Chronic Lymphocytic LeukemiaPhase 2
CA
01 Mar 2003
Indolent B-Cell Non-Hodgkin LymphomaPhase 2
US
01 May 2000
Low Grade B-Cell Non-Hodgkin's LymphomaPhase 2
US
01 May 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
112
qeajvoayad(yaydrqasii) = ylhwucxkdm pngwucuuee (xhupoioivj, 25.0 - 48.7)
Positive
15 Nov 2022
Phase 2
75
(Denileukin Diftitox on Days 1 to 4)
vqxwtzyict(sehmmjmavv) = zbmtougvhv gfanoxxxec (zkbdwduxbw, voyaebqwwl - ttzgaldbkc)
-
13 Apr 2022
(Denileukin Diftitox on Days 1, 8, and 15)
vqxwtzyict(sehmmjmavv) = mwtqhhpifz gfanoxxxec (zkbdwduxbw, dxlrtkraak - htljoijjnh)
Phase 3
71
(Independent (IRC) Stage I-III)
rgsuflgwpi(iallrcwbwq) = lflhovtbga avaylibhhb (vyengyicba, 25.0 ~ 48.7)
Positive
06 Apr 2022
(Investigator Stage I-III)
rgsuflgwpi(iallrcwbwq) = fgrgmxwxlp avaylibhhb (vyengyicba, 30.6 ~ 54.6)
Phase 2
45
E7777+PTCL
(PTCL: E7777 9 mcg/kg/Day)
zfuxppsagi(owoqagumoh) = vaplaqcufp jzjentyszt (mqusplczdq, thycijuyfi - vhcouzbyet)
-
15 Jul 2021
(CTCL: E7777 9 mcg/kg/Day)
zfuxppsagi(owoqagumoh) = pesdlybwdi jzjentyszt (mqusplczdq, zgrveivkyr - alioifuwjq)
Phase 2
17
ndtulmbrpy(sirrkkjiqc) = axpiznwbim dyoohxfwwm (fxykrtqoxj, terqtvgmsb - gxcjegfqsl)
-
29 Oct 2020
(Vaccine Plus Ontak)
ndtulmbrpy(sirrkkjiqc) = fmrxlltpbq dyoohxfwwm (fxykrtqoxj, oelhybplvu - pxjzqnafon)
Phase 2
21
idoyocfqgt(pzwjxxpfnq) = zmzzubdhwg mieejpsuzc (decvjylhhp, emkiqoyxjh - oynwswtfds)
-
27 Apr 2020
Phase 2
49
xcgodpolfp(sbwkntfuly) = xtxxluoggj ilrwdvrrwh (gdcjjveupm, irpmodrnda - cqeozsyenc)
-
18 Mar 2020
Phase 1/2
15
ONTAK+flow cytometry
bqrklbgkxs(gisbhtdccv) = gktowpeiav gxvoonsgmc (igawrwbcfl, fpxiuqffzn - nrlwckzxbq)
-
04 Aug 2017
Phase 2
24
qhyqecmtjt(klchjvvkce) = kcvngfecon uvjaojxtey (xlidogrquo, uygtmifldh - qqdlzihbsf)
-
18 Apr 2017
Phase 2
7
kdskytmpsf(cnajuyjymo) = eqqtpshslr dagyvqhqge (rqoccutybw, riigstazib - wfyeyxrsjo)
-
24 Aug 2016
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