Delving into the Latest Updates on Antazoline Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

2-(N-Benzylanilinomethyl)-2-imidazoline, 2-(N-Phenyl-N-benzylaminomethyl)imidazoline, 4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine

+ [2]

Target

H1 receptor

Action

antagonists

Mechanism

H1 receptor antagonists(Histamine H1 receptor antagonists)

Therapeutic Areas

Immune System DiseasesCardiovascular Diseases

Active Indication

Arrhythmias, CardiacHypersensitivity

Inactive Indication-

Originator Organization

Shanghai Zhongxi Sunve Pharmaceutical Co., Ltd.

Active Organization

Shanghai Zhongxi Sunve Pharmaceutical Co., Ltd.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC17H19N3

InChIKeyREYFJDPCWQRWAA-UHFFFAOYSA-N

CAS Registry91-75-8

View All Structures (2)

Abstract Ophthalmic pharmaceutical preparation containing antazoline (ANT) and tetryzoline (TET) is prescribed widely as an over the counter medication for allergic conjunctivitis treatment. Development of a selective, simple and environmentally friendly thin-layer chromatographic method established to determine both ANT and TET in their pure forms, pharmaceutical formulation and spiked aqueous humor samples. By using silica gel plates and means of a developing system consists of ethyl acetate:ethanol (5:5, by volume), the studied drugs separation was achieved, and scanning was carried out at 220.0 nm for the separated bands with a 0.2–18.0 μg/band concentration range for each of ANT and TET. Standard addition technique application was carried out to determine the proposed method validity. Statistical comparison was made between the proposed method and the official methods ANT and TET showing no significant difference concerning accuracy and precision. Furthermore, greenness profile assessment was accomplished by means of four metric tools, namely, analytical greenness, green analytical procedure index, analytical eco-scale and national environmental method index. Highlights

01 Sep 2024·Veterinary Microbiology

Case-control study to identify the causative agents of ophthalmia and conjunctivitis in goats in Savannakhet province of Lao PDR

Article

Author: Gerber, P F ; Jayasekara, P P ; Theppangna, W ; Walkden-Brown, S W ; Xaikhue, T ; Olmo, L ; Jenkins, C

Pinkeye is a highly contagious disease of goats with different aetiologies. Surveys in Lao PDR have identified eye lesions typical of pinkeye as a common condition, however, this has not been confirmed diagnostically, and the responsible pathogens have not been identified. A matched case-control study was implemented in 70 goat holdings from Savannakhet province, Lao PDR, to detect agents causing pinkeye and conduct phylogenetic analysis of the identified pathogens. Fifty eye swabs from goats with infected eyes (cases) and 50 paired samples from unaffected cohorts (controls) were collected from 25 holdings. Samples were tested using quantitative PCR assays targeting known pinkeye pathogens at the genus and species levels. The prevalence of pathogens in case and control goats was as follows: Mycoplasma conjunctivae (94% and 74% respectively, P = 0.006, OR = 5.5), Chlamydia pecorum (4%, 10%), Moraxella ovis (30%, 30%), Moraxella bovis (0%, 0%) and Moraxella bovoculi (0%, 0%). M. conjunctivae was present in a high proportion of goats in both groups revealing that Lao goats are carriers of M. conjunctivae. However, the mean log₁₀ genome copy number/µL of DNA extract was significantly higher in case goats than control goats (P < 0.05). Thus, M. conjunctivae is likely the principal causative agent of pinkeye in Lao goats with carrier status converting to clinical infection following corneal damage or other causative factors. M. conjunctivae detected in samples from different goats and districts showed low genetic diversity. Identifying the causes of pinkeye in Lao goats will assist in designing appropriate treatment and control strategies.

100 Deals associated with Antazoline Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D07459	Antazoline Hydrochloride	R01AC04 R06AX05	DB08799

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Arrhythmias, Cardiac	China	Shanghai Zhongxi Sunve Pharmaceutical Co., Ltd.	-
Hypersensitivity	China	Shanghai Zhongxi Sunve Pharmaceutical Co., Ltd.	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01527279 (AnPAF, Pubmed \| Europace)	Phase 4	Atrial Fibrillation	74	Antazoline	ulrtfollqf(ucqniseeet) = zeiqzhqvqz krbnsjpsfl (nxwtgrnagt )	Positive	01 Oct 2017
				Placebo	ulrtfollqf(ucqniseeet) = jueqcdhbmz krbnsjpsfl (nxwtgrnagt )
ESC2017	Not Applicable	Atrial fibrillation new onset	107	Antazoline	xsajlodwfi(eijuitnhop) = eqdkwhgxjm ccmdbthinf (fksgzkwvpj ) View more	-	28 Aug 2017
ESC2016	Not Applicable	-	10	Antazoline	pruiinxixm(thibcttnvv) = laailbpzeh daixnkfdoz (qanicmksnf ) View more	-	29 Aug 2016
				Sotalol	pruiinxixm(thibcttnvv) = elpvunimia daixnkfdoz (qanicmksnf ) View more