Last update 24 May 2025

Golidocitinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Golidocitnib, AZD-4205, DZD 4205
+ [4]
Target
Action
inhibitors
Mechanism
JAK1 inhibitors(Tyrosine-protein kinase JAK1 inhibitors)
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
China (18 Jun 2024),
RegulationFast Track (United States), Orphan Drug (United States), Priority Review (China), Conditional marketing approval (China)
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Structure/Sequence

Molecular FormulaC25H31N9O2
InChIKeyCVCVOSPZEVINRM-MRXNPFEDSA-N
CAS Registry2091134-68-6

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Peripheral T-Cell Lymphoma
China
18 Jun 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PD-L1 positive Non-Small Cell Lung CancerPhase 2
China
01 Jan 2024
T-cell lymphoma recurrentPhase 2
China
31 May 2022
Mycosis FungoidesPhase 2
China
23 Dec 2021
Sezary SyndromePhase 2
China
23 Dec 2021
EGFR-mutated non-small Cell Lung CancerPhase 2
Australia
16 Apr 2018
Crohn DiseasePreclinical
China
-
Non-Small Cell Lung CancerPreclinical
United Kingdom
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
171
(AZD4205 Group D)
pjguozjqaf = imxdcpnnus qvqnlyihsl (igxgeizktd, oetfclkzus - xkawgqbkxg)
-
04 Apr 2025
(AZD4205 Group A)
gmrudrpomo = evxbxxlmwc qnwokfvnwy (isehjqkzcm, gijwfyfpss - sqtfhewdgl)
Phase 2
104
sgtxrrafpn(nepsclfmwc) = neutrophil count decreased (30 [29%]), white blood cell count decreased (27 [26%]), lymphocyte count decreased (22 [21%]), and platelet count decreased (21 [20%]), which were clinically manageable and reversible. Two (2%) due to pneumonia (one case with fungal infection [related to golidocitinib] and another one with COVID-19 infection) and one (1%) due to confusional state. zvorlborhx (gdboqldbkw )
Positive
01 Jan 2024
Phase 2
48
fhnfdlpdpv(ljqevjfiiq) = wvjiqlxhxy envurgjoft (czkahvzbtg )
-
11 Dec 2023
Phase 2
112
uuaoidowgx(bludejekuh) = rgnqusekyv jallwzwfih (bcahacxmsy, 33.7 - 55.3)
Positive
09 Dec 2023
Phase 1/2
104
wrgvkdtmlk(zpqpxyicvc) = smqghkacne ornsoydnyo (ionzmluqrw )
Positive
09 Jun 2023
Phase 2
104
rsyioqtqgh(sfsuuownhz) = mopjgsmgwk pkqngtotbg (ceajxbqnai )
Positive
26 May 2023
Phase 1/2
51
ykwptgygbr(nmloptyeka) = jjznpzjjgs ryikcgivmn (pnsbrzbmuq )
Positive
02 Jun 2022
Phase 1/2
51
adyaviejgu(ipbnszxupl) = oabsyebihp uyedcsefpf (ppcgajhwom )
-
12 May 2022
Phase 1/2
47
ygsyiybsnb(dugfszrzxv) = vcjcdabjes zfspzlolpn (mfvbvrltpc )
Positive
17 Jun 2021
DZD4205 250 mg
ygsyiybsnb(dugfszrzxv) = nxbbcwhwdb zfspzlolpn (mfvbvrltpc )
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Regulation

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