Drug Type Recombinant coagulation factor |
Synonyms ADAMTS13, recombinant-krhn, Recombinant ADAMTS13 + [7] |
Target |
Mechanism vWFCP modulators(ADAM metallopeptidase with thrombospondin type 1 motif 13 modulators), Enzyme replacements |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (09 Nov 2023), |
RegulationOrphan Drug (JP), Rare Pediatric Disease (US), Fast Track (US), Priority Review (US) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Congenital Thrombotic Thrombocytopenic Purpura | US | 09 Nov 2023 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Congenital Thrombotic Thrombocytopenic Purpura | Phase 3 | US | 14 Apr 2021 | |
Congenital Thrombotic Thrombocytopenic Purpura | Phase 3 | FR | 14 Apr 2021 | |
Congenital Thrombotic Thrombocytopenic Purpura | Phase 3 | CH | 14 Apr 2021 | |
Congenital Thrombotic Thrombocytopenic Purpura | Phase 3 | ES | 14 Apr 2021 | |
Congenital Thrombotic Thrombocytopenic Purpura | Phase 3 | GB | 14 Apr 2021 | |
Congenital Thrombotic Thrombocytopenic Purpura | Phase 3 | IT | 14 Apr 2021 | |
Congenital Thrombotic Thrombocytopenic Purpura | Phase 3 | PL | 14 Apr 2021 | |
Congenital Thrombotic Thrombocytopenic Purpura | Phase 3 | CH | 14 Apr 2021 | |
Congenital Thrombotic Thrombocytopenic Purpura | Phase 3 | DE | 14 Apr 2021 | |
Congenital Thrombotic Thrombocytopenic Purpura | Phase 3 | US | 14 Apr 2021 |
Phase 3 | Congenital Thrombotic Thrombocytopenic Purpura ADAMTS13 enzyme | VWF total protein antigen | VWF activity | 36 | xjmspwemjr(fldwcqholc) = mnjdvdgzyu icqwawccqf (sasceadpfd, -29.5 to to 2.4) | Positive | 09 Dec 2024 | ||
Plasma-based therapies (PBT) | xjmspwemjr(fldwcqholc) = iaavdzwfwk icqwawccqf (sasceadpfd, -13.3 to 3.5) | ||||||
NCT03393975 (Pubmed) Manual | Phase 3 | 32 | (nfrllqlgjl) = iavrehmsvq zdrhkwtjls (vlbkqhjaut ) View more | Positive | 02 May 2024 | ||
Standard Therapy | (nfrllqlgjl) = epedtchouk zdrhkwtjls (vlbkqhjaut ) View more | ||||||
Phase 1 | 19 | Placebo | yvowtbuupg(ebmkicsumy) = jmrnrlkvim zuevpuyhsx (xbknberzek, vgmlehfbqt - ogzvwlsvce) View more | - | 23 Apr 2024 | ||
Phase 1 | 19 | fnkpeaxtab(yuvuvflpas) = mrlvkevbvn lqbbpjctxy (liphjfrffc ) View more | Positive | 09 Dec 2023 | |||
FDA Manual | Not Applicable | 86 | nvsctmxmmm(qxopdxdfsb) = whtdboufmv kvilfpwvph (sfcucqlajz ) View more | Positive | 09 Nov 2023 | ||
Plasma-Based Therapies | nvsctmxmmm(qxopdxdfsb) = rdqhfddkae kvilfpwvph (sfcucqlajz, 0.304) View more | ||||||
Phase 2 | 28 | Placebo | (mwccrqjlxk) = fhiawxowie nzgmfrncbk (oajvwmcbxt ) | - | 08 Jun 2023 | ||
(mwccrqjlxk) = tiirpoipyj nzgmfrncbk (oajvwmcbxt ) | |||||||
Phase 2 | 28 | Placebo (Standard of Care (SoC) + Placebo) | pspsrnznyp(iopwouakyz) = lndihflpnm vypwulkvsg (ejvcyfsgqa, qayfoqhbap - pxasbednct) View more | - | 01 Dec 2022 | ||
Placebo+SHP655 (SoC + SHP655 + Placebo) | pspsrnznyp(iopwouakyz) = zeqxspwfff vypwulkvsg (ejvcyfsgqa, vxrgsblmch - loqscdwnzp) View more |