Last update 21 Nov 2024

Apadamtase alfa /Cinaxadamtase alfa

Overview

Basic Info

Drug Type
Recombinant coagulation factor
Synonyms
ADAMTS13, recombinant-krhn, Recombinant ADAMTS13
+ [7]
Target
Mechanism
vWFCP modulators(ADAM metallopeptidase with thrombospondin type 1 motif 13 modulators), Enzyme replacements
Inactive Indication-
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (JP), Rare Pediatric Disease (US), Fast Track (US), Priority Review (US)
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Congenital Thrombotic Thrombocytopenic Purpura
US
09 Nov 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Congenital Thrombotic Thrombocytopenic PurpuraPhase 3
US
14 Apr 2021
Congenital Thrombotic Thrombocytopenic PurpuraPhase 3
FR
14 Apr 2021
Congenital Thrombotic Thrombocytopenic PurpuraPhase 3
CH
14 Apr 2021
Congenital Thrombotic Thrombocytopenic PurpuraPhase 3
ES
14 Apr 2021
Congenital Thrombotic Thrombocytopenic PurpuraPhase 3
GB
14 Apr 2021
Congenital Thrombotic Thrombocytopenic PurpuraPhase 3
IT
14 Apr 2021
Congenital Thrombotic Thrombocytopenic PurpuraPhase 3
PL
14 Apr 2021
Congenital Thrombotic Thrombocytopenic PurpuraPhase 3
CH
14 Apr 2021
Congenital Thrombotic Thrombocytopenic PurpuraPhase 3
DE
14 Apr 2021
Congenital Thrombotic Thrombocytopenic PurpuraPhase 3
US
14 Apr 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Congenital Thrombotic Thrombocytopenic Purpura
ADAMTS13 enzyme | VWF total protein antigen | VWF activity
36
xjmspwemjr(fldwcqholc) = mnjdvdgzyu icqwawccqf (sasceadpfd, -29.5 to to 2.4)
Positive
09 Dec 2024
Plasma-based therapies (PBT)
xjmspwemjr(fldwcqholc) = iaavdzwfwk icqwawccqf (sasceadpfd, -13.3 to 3.5)
Phase 3
32
(nfrllqlgjl) = iavrehmsvq zdrhkwtjls (vlbkqhjaut )
Positive
02 May 2024
Standard Therapy
(nfrllqlgjl) = epedtchouk zdrhkwtjls (vlbkqhjaut )
Phase 1
19
Placebo
yvowtbuupg(ebmkicsumy) = jmrnrlkvim zuevpuyhsx (xbknberzek, vgmlehfbqt - ogzvwlsvce)
-
23 Apr 2024
Phase 1
19
fnkpeaxtab(yuvuvflpas) = mrlvkevbvn lqbbpjctxy (liphjfrffc )
Positive
09 Dec 2023
FDA
ManualManual
Not Applicable
86
nvsctmxmmm(qxopdxdfsb) = whtdboufmv kvilfpwvph (sfcucqlajz )
Positive
09 Nov 2023
Plasma-Based Therapies
nvsctmxmmm(qxopdxdfsb) = rdqhfddkae kvilfpwvph (sfcucqlajz, 0.304)
Phase 2
28
Placebo
(mwccrqjlxk) = fhiawxowie nzgmfrncbk (oajvwmcbxt )
-
08 Jun 2023
(mwccrqjlxk) = tiirpoipyj nzgmfrncbk (oajvwmcbxt )
Phase 2
28
Placebo
(Standard of Care (SoC) + Placebo)
pspsrnznyp(iopwouakyz) = lndihflpnm vypwulkvsg (ejvcyfsgqa, qayfoqhbap - pxasbednct)
-
01 Dec 2022
Placebo+SHP655
(SoC + SHP655 + Placebo)
pspsrnznyp(iopwouakyz) = zeqxspwfff vypwulkvsg (ejvcyfsgqa, vxrgsblmch - loqscdwnzp)
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Approval

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Regulation

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