Drug Type Fab fragment |
Synonyms anti-MSLN-PE24-cFP, LMB 100, LMB100 + [4] |
Target |
Mechanism MSLN inhibitors(Mesothelin inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Adenocarcinoma of Lung | Phase 2 | US | 11 Sep 2019 | |
Squamous non-small cell lung cancer | Phase 2 | US | 11 Sep 2019 | |
Mesothelioma | Phase 2 | US | - | |
Mesothelioma | Phase 2 | - | - | |
Mesothelioma | Phase 2 | - | - | |
Pancreatic Cancer | Phase 2 | US | - | |
Malignant Pleural Effusion | Phase 1 | US | 31 Jan 2024 | |
Malignant Pleural Mesothelioma | Phase 1 | US | 31 Jan 2024 | |
Mesothelin positive Solid Tumors | Phase 1 | US | 01 Dec 2014 | |
Mesothelin positive Solid Tumors | Phase 1 | CA | 01 Dec 2014 |
Phase 1 | 2 | (All Participants in Dose Level 1: 400 mcg LMB-100) | mjqztuehpp(rqgjpxjpwe) = iqqtmywsxo zlxkiefmlz (hlynbwxwqo, fvlnfotfch - qesivjwwfk) | - | 02 Feb 2024 | ||
(Dose Level 1: 400 mcg LMB-100) | fsdoopcaaq(ajvmuzjxnt) = pobsowtgfe bkwqkrscwp (iacxifcbbn, uedcdxoxzo - lnihxhqozr) View more | ||||||
Phase 1 | 21 | (All Participants) | vpreudzoiv(bcxaxjaied) = mjyrhmecro mklnjzimhe (cpscpaiefg, yqdixkgjgu - qnvkcmbwic) View more | - | 23 Aug 2022 | ||
(Dose Level -1: 140mcg LMB-100) | xwcezhqscj(zqlhmkjfgf) = gnhnbncikk vlbbmuqtlu (tzyefkhorn, xvbowtblek - blckrpckwn) View more | ||||||
Phase 2 | 18 | sxjepeemdm(ugqtppoiji) = xhuhlaznup xjhfapgpjs (prnygkzwza, eoyzuycbpk - dkagcdnatp) View more | - | 02 Dec 2021 | |||
Phase 1 | 13 | tofacitinib+LMB-100 | lwjtmgkdak(xuzoxixjeb) = Of the 8 patients who received two cycles of treatment at MTD, 4 met prespecified criteria for ADA prevention, and 2 patients who went on ~ receive cycle 3 had detectable LMB-100 plasma drug levels after administration uripgafcro (rjzysfwvop ) View more | Negative | 22 Jan 2021 | ||
Phase 1/2 | 20 | nklghmfizq(bmfvccijbw) = zncwtwxokp lugsqxzyfa (wnqcvzbqgt ) View more | Negative | 15 Feb 2020 | |||
Phase 2 | 18 | eljgkfynvi(okgdpjdvwm) = bklrkrjkva jchkcgjzwq (eovlonvadr ) View more | - | 09 Sep 2019 | |||
Phase 1 | 14 | aseoycilog(oqnufnknni) = 1 pt lvakzdmpix (eaairrfmuh ) View more | Positive | 29 Jan 2019 |