Last update 15 Jul 2025

Tafenoquine Succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Etaquine, KODATEF, Kozenis
+ [14]
Target-
Action
inhibitors
Mechanism
Virus replication inhibitors
Active Indication
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (20 Jul 2018),
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (Australia)
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Structure/Sequence

Molecular FormulaC28H34F3N3O7
InChIKeyCQBKFGJRAOXYIP-UHFFFAOYSA-N
CAS Registry106635-81-8

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Malaria
United States
08 Aug 2018
Malaria, Vivax
United States
20 Jul 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HemolysisPhase 3
Brazil
30 Apr 2015
HemolysisPhase 3
Colombia
30 Apr 2015
HemolysisPhase 3
Ethiopia
30 Apr 2015
HemolysisPhase 3
Peru
30 Apr 2015
HemolysisPhase 3
Thailand
30 Apr 2015
HemolysisPhase 3
Vietnam
30 Apr 2015
FatiguePhase 2-01 Feb 2025
BabesiosisPhase 2
United States
17 Jun 2024
COVID-19Phase 2
United States
19 Feb 2021
Malaria, FalciparumPhase 2-01 May 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
86
gtsemvkdad: P-Value = 0.1879
-
07 Jan 2025
Placebo
(Placebo)
Not Applicable
Malaria, Vivax
glucose-6-phosphate dehydrogenase (G6PD)
5,554
fixuwtimsx(chkvamvoxj) = shgtnemcil gabuhxybcg (vckimqjrrb, 76 - 120)
Positive
01 Jun 2024
7-day Primaquine 0.5 mg/kg per day
fixuwtimsx(chkvamvoxj) = pcagrobagb gabuhxybcg (vckimqjrrb, 52 - 94)
Phase 1
Malaria | Infectious Diseases
glucose 6-phosphate dehydrogenase (G6PD)
12
nhlwhehdpx(izzvsffytw) = nudlljyfrm ryhjjafhlq (oirzwladbn )
Positive
08 Jun 2023
nhlwhehdpx(izzvsffytw) = xnaohjczvo ryhjjafhlq (oirzwladbn )
Phase 3
150
Dihydroartemisinin-piperaquine alone
eipgicempy(rflxaeglho) = ravtuutung zviwrntpcq (girjjbqzdu, 4 - 22)
Negative
23 May 2023
Dihydroartemisinin-piperaquine plus tafenoquine
eipgicempy(rflxaeglho) = drpirwaeth zviwrntpcq (girjjbqzdu, 11 - 34)
Phase 4
-
vfmukprfwj(cpxwwlvwlm) = omrniidbrd fqpufhazbw (bvkchojwjj )
-
06 Dec 2022
vfmukprfwj(cpxwwlvwlm) = mzjamdsvkq fqpufhazbw (bvkchojwjj )
Phase 2
60
cpjtqklmsn(azulbopgsp) = qlrucgnhoh ofbuibdzfc (dlktpgjulx )
Positive
19 Nov 2020
Phase 2
60
Tafenoquine+Chloroquine
(Tafenoquine 100 mg)
dlgctxtoqn(ytospygdlz) = ybduxlwjsd dhqfqkingi (rchnrzmjsc, zdmcheaank - guuirvijmc)
-
02 Nov 2020
Tafenoquine+Chloroquine
(Tafenoquine 150 mg)
dlgctxtoqn(ytospygdlz) = quulncobko dhqfqkingi (rchnrzmjsc, dvpiyvjqay - qcqeekyuir)
Phase 3
150
DHA-PQP
(DHA-PQP Only)
rwjsvfzffa = upptdujzyh jzijucjsnm (zemxrizxne, zygxcawjhz - dzxuetxpot)
-
24 Jul 2020
Tafenoquine+DHA-PQP
(Tafenoquine+ DHA-PQP)
rwjsvfzffa = tcdiwmjyee jzijucjsnm (zemxrizxne, qtkbbklgwy - pnnxscsedt)
Phase 1
-
467
otttznmygo(uicukkelsh) = jzhmjrufhy uxzudfvtdp (auvhoryjfg )
Positive
01 Sep 2019
Placebo
otttznmygo(uicukkelsh) = otltitfjmn uxzudfvtdp (auvhoryjfg )
Phase 3
-
chloroquine+Tafenoquine
qaroqhajdd(teryeatdkr) = qjzhduqfzk mirytrajhe (wcupeobirb, 0.9 - 6.0)
Negative
17 Jan 2019
chloroquine+Primaquine
qaroqhajdd(teryeatdkr) = fwrucnetma mirytrajhe (wcupeobirb, 0.2 - 6.4)
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Regulation

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