Last update 14 Dec 2024

Glumetinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
6-(1-methyl-1h-pyrazol-4-yl)-1-((6-(1-methyl-1h-pyrazol-4-yl)imidazo(1,2-a)pyridin-3-yl)sulfonyl)-1h-pyrazolo(4,3-b)pyridine, Gumarontinib, Gumarontinib Hydrate
+ [5]
Target
Mechanism
c-Met inhibitors(Hepatocyte growth factor receptor inhibitors)
Inactive Organization-
Drug Highest PhaseApproved
RegulationPriority Review (CN), Breakthrough Therapy (CN), Conditional marketing approval (CN), Special Review Project (CN), Orphan Drug (US)
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Structure

Molecular FormulaC21H17N9O2S
InChIKeyRYBLECYFLJXEJX-UHFFFAOYSA-N
CAS Registry1642581-63-2

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
c-Met positive non-small cell lung cancer
JP
24 Jun 2024
MET Exon 14 Skipping Mutation Non-small Cell Lung Cancer
CN
07 Mar 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 2-01 Jun 2024
metastatic non-small cell lung cancerPhase 2
CN
11 May 2020
metastatic non-small cell lung cancerPhase 2
CN
11 May 2020
Recurrent Non-Small Cell Lung CancerPhase 2
CN
18 Nov 2019
c-Met positive Adenocarcinoma of EsophagusPhase 2
CN
31 Jul 2019
c-Met positive Adenocarcinoma of EsophagusPhase 2
CN
31 Jul 2019
Pulmonary sarcomatoid carcinomaPhase 2
CN
31 Jul 2019
Pulmonary sarcomatoid carcinomaPhase 2
CN
31 Jul 2019
Advanced Lung Non-Small Cell CarcinomaPhase 2
US
15 Jul 2019
Advanced Lung Non-Small Cell CarcinomaPhase 2
CN
15 Jul 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
32
dmvqnbcztj(akcdcbtawc) = mrhrwerhly zhqhqyppnx (elszbqkkki, 21.1 - 56.3)
Positive
03 Dec 2022
(treatment naïve patients)
dmvqnbcztj(akcdcbtawc) = fovymiqrtv zhqhqyppnx (elszbqkkki, 15.2 - 72.3)
Phase 2
30
lvyyxboucg(csdjgmarlg) = vfmxdqbeaz cnbvluljah (qrgwqqkamo, [40.6 - 77.3])
-
03 Dec 2022
Phase 1
19
bkynmuvhip(aqiskutelo) = tviygvggfx bappmptznx (nmkprjxuai )
-
01 Mar 2021
Phase 1
18
onaubxmwcp(ziqzjjrjwl) = Peripheral edema (n = 1, 5.5%), hypothyroidism (n = 1, 5.5%) ztehmhielj (ewtyooybfy )
Positive
25 May 2020
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Regulation

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