Last update 10 Apr 2025

Glumetinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Gumarontinib, Gumarontinib Hydrate, HH-SCC244
+ [4]
Target
Action
inhibitors
Mechanism
c-Met inhibitors(Hepatocyte growth factor receptor inhibitors)
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States), Priority Review (China), Breakthrough Therapy (China), Conditional marketing approval (China), Special Review Project (China)
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Structure/Sequence

Molecular FormulaC21H17N9O2S
InChIKeyRYBLECYFLJXEJX-UHFFFAOYSA-N
CAS Registry1642581-63-2

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
c-Met positive non-small cell lung cancer
Japan
24 Jun 2024
MET Exon 14 Skipping Mutation Non-small Cell Lung Cancer
China
07 Mar 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
EGFR mutation MET positive Non-small Cell Lung CancerPhase 3
China
03 Apr 2025
EGFR mutation MET positive Non-small Cell Lung CancerPhase 3
China
03 Apr 2025
Non-Small Cell Lung CancerPhase 3
China
03 Apr 2025
metastatic non-small cell lung cancerPhase 2
China
11 May 2020
metastatic non-small cell lung cancerPhase 2
China
11 May 2020
Recurrent Non-Small Cell Lung CancerPhase 2
China
18 Nov 2019
c-Met positive Adenocarcinoma of EsophagusPhase 2
China
31 Jul 2019
c-Met positive Adenocarcinoma of EsophagusPhase 2
China
31 Jul 2019
Pulmonary sarcomatoid carcinomaPhase 2
China
31 Jul 2019
Pulmonary sarcomatoid carcinomaPhase 2
China
31 Jul 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
84
SCC244 300 mg once daily
hanmlacsxb(kkybjoulms) = adncjostez gcwodjaeyb (rlcdxnazvt, 54.3 - 76.1)
Positive
07 Dec 2024
SCC244 300 mg once daily
(treatment-naïve)
hanmlacsxb(kkybjoulms) = thvlyxbikp gcwodjaeyb (rlcdxnazvt, 54.8 - 83.2)
Phase 1/2
32
ewfhsrxusz(hfqllushvl) = jbstazqshg gwxtrysfxc (klhfifzqmr, 63.6 - 92.8)
Positive
01 Jan 2024
Phase 1/2
84
rgklkkohch(paitamesms) = 32/84, 38% putaaeeoty (virumidggi )
-
01 May 2023
Phase 1
32
zucbhedtpi(rvckoopmgw) = aoqjtwmjvf xhtavwwamd (ljbasqhgoj, 21.1 - 56.3)
Positive
03 Dec 2022
(treatment naïve patients)
zucbhedtpi(rvckoopmgw) = hobddwkpdj xhtavwwamd (ljbasqhgoj, 15.2 - 72.3)
Phase 2
30
ntrlfbkhjw(ygbqkbngxv) = miicpqgkyn sxugxsqvyn (qkevmzbeip, [40.6 - 77.3])
-
03 Dec 2022
Phase 1
Non-Small Cell Lung Cancer
c-MET status | c-MET ex14 skipping mutation | c-MET IHC 3+
19
ljpzdpbbkq(kzhpgojyua) = ucwlfqhcmq rjhbvmbjzf (pvzlcflwiw )
-
01 Mar 2021
Phase 1
18
hhrfchjpmv(fojrfuvmza) = Peripheral edema (n = 1, 5.5%), hypothyroidism (n = 1, 5.5%) fxyivkitwh (hadqyumnqh )
Positive
25 May 2020
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