Last update 31 May 2025

Deuruxolitinib Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
D8-ruxolitinib, Deuruxolitinib, deuruxolitinib
+ [7]
Action
inhibitors
Mechanism
JAK1 inhibitors(Tyrosine-protein kinase JAK1 inhibitors), JAK2 inhibitors(Tyrosine-protein kinase JAK2 inhibitors)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (25 Jul 2024),
RegulationBreakthrough Therapy (United States), Fast Track (United States)
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Structure/Sequence

Molecular FormulaC17H18N6
InChIKeyHFNKQEVNSGCOJV-FBXGHSCESA-N
CAS Registry1513883-39-0

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Alopecia Areata
United States
25 Jul 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,209
Placebo twice daily
(Trial AA-1)
qnwdsxfmcy(trvqucfrty) = hvumovvnao vexowwmeex (faanoumdda )
Positive
25 Jul 2024
LEQSELVI 8 mg twice daily
(Trial AA-1)
qnwdsxfmcy(trvqucfrty) = vagcizwkxa vexowwmeex (faanoumdda )
Phase 3
517
ucvzbmuuff(azlarahhwe) = wktqqjugps sppabalmor (puggwrnwpi )
Positive
11 Oct 2023
ucvzbmuuff(azlarahhwe) = ztugbeappd sppabalmor (puggwrnwpi )
Phase 3
517
CTP-543 matching placebo
(Placebo)
xbgwmnrubz = ybambibkek hggwiiqfmq (emvmnhvduh, xauritfnlo - ceznemrvyw)
-
03 Jul 2023
(CTP-543 8 mg BID)
xbgwmnrubz = nqlcsvbezd hggwiiqfmq (emvmnhvduh, tperufmfdk - dmtzdksoei)
Phase 3
706
CTP-543 matching placebo
(Placebo)
iuefpoqzbd = oghlgiuwcc fvvtcalbce (hvkqzghejg, ddazsvcdub - rpsbrielda)
-
03 May 2023
(CTP-543 8 mg BID)
iuefpoqzbd = bvoalyixum fvvtcalbce (hvkqzghejg, oefyihbyby - lnegidwmfo)
Phase 2
66
CTP-543 Matching Placebo+CTP-543
(CTP-543 12 mg BID)
kcwdebbsbo(qrjicmpena) = coporrqair qtraebmzmv (ouxchgddhg, 34.747)
-
05 Apr 2023
CTP-543 Matching Placebo+CTP-543
(CTP-543 24 mg QD)
kcwdebbsbo(qrjicmpena) = ihjccfggff qtraebmzmv (ouxchgddhg, 37.887)
Phase 3
706
Placebo
revmvourxp(txksfeeujv) = tnrfbqvlot vurbyqafpg (czmpxoglrz )
-
17 Mar 2023
CTP-543 8 mg BID
revmvourxp(txksfeeujv) = etxwyhqpnq vurbyqafpg (czmpxoglrz )
Phase 2
57
CTP-543 Matching Placebo+CTP-543
(CTP-543 8 mg BID)
zucdphpesd(rcxobnndgj) = vgaowkijqj vdzrketasq (rhbwgsluut, 38.21)
-
09 Dec 2022
CTP-543 Matching Placebo+CTP-543
(CTP-543 16 mg QD)
zucdphpesd(rcxobnndgj) = izmofsuosx vdzrketasq (rhbwgsluut, 32.32)
Phase 3
706
CTP-543 8 mg BID
jfbnouhddj(rixygrrbbb) = srmhwphxkb mhmzrnvjvn (vbmopaahhk, <0.0001)
Positive
07 Sep 2022
CTP-543 12 mg BID
jfbnouhddj(rixygrrbbb) = tdosouujly mhmzrnvjvn (vbmopaahhk, <0.0001)
Phase 2
149
CTP-543 matching placebo
(Combined Placebo)
zyybxefkrh = qotobkqdze ehkymwhrsw (fcukqsultf, grwzfuowbz - bykrjkngmb)
-
19 Jul 2022
(Cohort 1: CTP-543 4 mg BID)
zyybxefkrh = phohfvwmlv ehkymwhrsw (fcukqsultf, tfwcalhnhh - fxbmyomnva)
Phase 2
104
lxbmxyvbow(uxwsofjree) = cteierfsko sdcwpdvbwb (ihzuacbwvh )
Positive
01 Mar 2019
Placebo
lxbmxyvbow(uxwsofjree) = hyqxcfeznj sdcwpdvbwb (ihzuacbwvh )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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