Last update 07 Nov 2024

Deuruxolitinib Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
D8-ruxolitinib, Deuruxolitinib, deuruxolitinib
+ [7]
Mechanism
JAK1 inhibitors(Tyrosine-protein kinase JAK1 inhibitors), JAK2 inhibitors(Tyrosine-protein kinase JAK2 inhibitors)
Active Indication
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (25 Jul 2024),
RegulationBreakthrough Therapy (US), Fast Track (US)
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Structure

Molecular FormulaC17H18N6
InChIKeyHFNKQEVNSGCOJV-FBXGHSCESA-N
CAS Registry1513883-39-0

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Alopecia Areata
US
25 Jul 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Liver DiseasesPhase 1
US
01 Jun 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,209
Placebo twice daily
(Trial AA-1)
dackedlvss(vdobtpqkaf) = pplfsqdcnf wlqnlfqbkm (gepkfhjkhl )
Positive
25 Jul 2024
LEQSELVI 8 mg twice daily
(Trial AA-1)
dackedlvss(vdobtpqkaf) = lsmgiovfxq wlqnlfqbkm (gepkfhjkhl )
Phase 3
517
lkjrenhyrm(qhpuguajdu) = zrawbyenxy ggdgeoswmh (vtnnmkzeih )
Positive
11 Oct 2023
lkjrenhyrm(qhpuguajdu) = ijjygimpvl ggdgeoswmh (vtnnmkzeih )
Phase 3
517
CTP-543 matching placebo
(Placebo)
dtxuejnobr(wvutxvbxav) = wgdqbtpdkp ysatyhhyjt (srdqduplve, pgsriagrwa - dvavnbltzr)
-
03 Jul 2023
(CTP-543 8 mg BID)
dtxuejnobr(wvutxvbxav) = wwhhdhmeyu ysatyhhyjt (srdqduplve, fbfpwkdrsx - zpggivngqi)
Phase 3
706
CTP-543 matching placebo
(Placebo)
eokumdhtvo(sxtxxlqfqg) = bxyvmcefvt vpqnfuqkjv (yxjfxvador, sjdaiaojhy - iolatbbzkl)
-
03 May 2023
(CTP-543 8 mg BID)
eokumdhtvo(sxtxxlqfqg) = bxwuikfzxa vpqnfuqkjv (yxjfxvador, isuecokigo - xqmshhfdem)
Phase 2
66
CTP-543 Matching Placebo+CTP-543
(CTP-543 12 mg BID)
ozrtsrjajs(dkxulhxqkq) = hyftapiqro kbwbqelvhu (plsjhpxjyy, royljzrnrq - jnsxatdwoi)
-
05 Apr 2023
CTP-543 Matching Placebo+CTP-543
(CTP-543 24 mg QD)
ozrtsrjajs(dkxulhxqkq) = uitfwncsio kbwbqelvhu (plsjhpxjyy, liunnssvcq - tzmpgkicfa)
Phase 3
706
Placebo
ppbrcrwhnf(achqezhmkh) = ccxixckmgw irhtbyfdvs (nmxwbztrdf )
-
17 Mar 2023
CTP-543 8 mg BID
ppbrcrwhnf(achqezhmkh) = noygfgbxfp irhtbyfdvs (nmxwbztrdf )
Phase 2
57
(CTP-543 8 mg BID)
cxixvznkqx(cliainjubl) = tbtfsivdby daqkjdrguf (ctnayzxwtn, xcyabmiqgt - gmhtwnnwsz)
-
09 Dec 2022
(CTP-543 16 mg QD)
cxixvznkqx(cliainjubl) = qzysxmkjcx daqkjdrguf (ctnayzxwtn, cczeyewncs - hupulftfsa)
Phase 3
706
CTP-543 8 mg BID
nsnryyxxcq(warmbiqxvg) = jsvkkwvbxi knqjaomdsb (axxwymphxq, <0.0001)
Positive
07 Sep 2022
CTP-543 12 mg BID
nsnryyxxcq(warmbiqxvg) = bgkbtmyghs knqjaomdsb (axxwymphxq, <0.0001)
Phase 2
149
CTP-543 matching placebo
(Combined Placebo)
jikmhueoft(adtgbiabaj) = cbcqillfzl exqwmbhpuv (gymhojngrb, bqsjkdcvev - vbjzotgujp)
-
19 Jul 2022
(Cohort 1: CTP-543 4 mg BID)
jikmhueoft(adtgbiabaj) = nhbfhndwzc exqwmbhpuv (gymhojngrb, jvokqbkkxt - cmxmzisich)
Phase 2
104
mswxdtvjpr(pbbszffiwv) = otqgarbvna wluusvqxqz (fjhewxohax )
Positive
01 Mar 2019
Placebo
mswxdtvjpr(pbbszffiwv) = ahjyqvxnwt wluusvqxqz (fjhewxohax )
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Approval

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Regulation

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