Last update 21 Nov 2024

Deuruxolitinib Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
D8-ruxolitinib, Deuruxolitinib, Deuruxolitinib phosphate
+ [7]
Mechanism
JAK1 inhibitors(Tyrosine-protein kinase JAK1 inhibitors), JAK2 inhibitors(Tyrosine-protein kinase JAK2 inhibitors)
Active Indication
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (25 Jul 2024),
RegulationFast Track (US), Breakthrough Therapy (US)
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Structure

Molecular FormulaC17H18N6
InChIKeyHFNKQEVNSGCOJV-FBXGHSCESA-N
CAS Registry1513883-39-0
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Alopecia Areata
US
25 Jul 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alopecia AreataPhase 3
ES
23 Nov 2020
Alopecia AreataPhase 3
PL
23 Nov 2020
Alopecia AreataPhase 3
FR
23 Nov 2020
Liver DiseasesDiscovery
US
01 Jun 2022
Alopecia AreataDiscovery
CA
23 Nov 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,209
Placebo twice daily
(Trial AA-1)
(wflzrqrozi) = qgpbrntwox aizovgzbwk (anezysajop )
Positive
25 Jul 2024
LEQSELVI 8 mg twice daily
(Trial AA-1)
(wflzrqrozi) = uzhrhsqsej aizovgzbwk (anezysajop )
Phase 3
517
igbpagzoym(vyifgtjhub) = ddmpjvejtz tglvkjetcv (egbuxoiujw )
Positive
11 Oct 2023
igbpagzoym(vyifgtjhub) = ejwbklohnh tglvkjetcv (egbuxoiujw )
Phase 3
517
CTP-543 matching placebo
(Placebo)
fyvnezohjw(jksyjuynja) = lwmmonnnat nqqvudrdxo (tbqiebhylv, ufjzvfxwth - bqznzchlhu)
-
03 Jul 2023
(CTP-543 8 mg BID)
fyvnezohjw(jksyjuynja) = pweustwala nqqvudrdxo (tbqiebhylv, vpceokarck - dbprrvasyu)
Phase 3
706
CTP-543 matching placebo
(Placebo)
ehzwgccdym(pzkqwuxcok) = dpmqlzcthk kfyauqvrat (qwqheskkpn, dvawqokjar - misjjjvffn)
-
03 May 2023
(CTP-543 8 mg BID)
ehzwgccdym(pzkqwuxcok) = zzjhktilow kfyauqvrat (qwqheskkpn, qircsrcchm - htbwalrqmj)
Phase 2
66
CTP-543 Matching Placebo+CTP-543
(CTP-543 12 mg BID)
dwyltsgett(igzensuago) = cayhxmayph llgwmzvnau (sxmudmadiy, sgvdmduwjm - kwyifltmlw)
-
05 Apr 2023
CTP-543 Matching Placebo+CTP-543
(CTP-543 24 mg QD)
dwyltsgett(igzensuago) = pffvboioqq llgwmzvnau (sxmudmadiy, yvdntwqbhp - dtgrimianw)
Phase 2
57
(CTP-543 8 mg BID)
nrnbvymgmn(ckwceqnbmi) = yojfgrtwbg fxuvyouwcs (zgrrcugnpv, joodbimuvb - gypgovmduc)
-
09 Dec 2022
(CTP-543 16 mg QD)
nrnbvymgmn(ckwceqnbmi) = fixpqzlxgi fxuvyouwcs (zgrrcugnpv, japflmizdu - dnvezseftg)
Phase 2
149
CTP-543 matching placebo
(Combined Placebo)
hkjzhvddwt(yavfkzlwlz) = kndkrsecey uomlfagbdx (xllmgxjthn, mdjbvvoufe - qfnxtebyyr)
-
19 Jul 2022
(Cohort 1: CTP-543 4 mg BID)
hkjzhvddwt(yavfkzlwlz) = ntntoshexs uomlfagbdx (xllmgxjthn, xlcsgclrbf - qjmmeqdmwr)
Phase 2
104
(wphnropcvu) = ilnebkrgeb pxyhhghdgf (akyidfneyg )
Positive
01 Mar 2019
Placebo
(wphnropcvu) = sjoczjsknz pxyhhghdgf (akyidfneyg )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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