Last update 07 Nov 2024

Tavapadon

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tavapadon (USAN), CVL 751, CVL-751
+ [3]
Mechanism
D1 receptor agonists(Dopamine D1 receptor agonists), D5 receptor agonists(Dopamine D5 receptor agonists)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC19H16F3N3O3
InChIKeyAKQXQLUNFKDZBN-UHFFFAOYSA-N
CAS Registry1643489-24-0

External Link

KEGGWikiATCDrug Bank
D11431Tavapadon-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Motor DisordersPhase 3
US
27 Oct 2020
Motor DisordersPhase 3
AU
27 Oct 2020
Motor DisordersPhase 3
BG
27 Oct 2020
Motor DisordersPhase 3
CZ
27 Oct 2020
Motor DisordersPhase 3
FR
27 Oct 2020
Motor DisordersPhase 3
DE
27 Oct 2020
Motor DisordersPhase 3
IL
27 Oct 2020
Motor DisordersPhase 3
IT
27 Oct 2020
Motor DisordersPhase 3
PL
27 Oct 2020
Motor DisordersPhase 3
RS
27 Oct 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
(5 mg/day)
dwjspsmwao(isknjfxslh) = gqcyvqmjql dtaexuahgj (hzzhigltms )
Met
Positive
27 Sep 2024
(15 mg/day)
dwjspsmwao(isknjfxslh) = ivgotbtzdg dtaexuahgj (hzzhigltms )
Met
Phase 3
-
iqnsyoumtd(ugklqzyfcx) = Patients treated with tavapadon adjunctive to LD experienced a clinically meaningful increase of 1.1 hours in total “on” time without troublesome dyskinesia compared to those treated with LD and placebo. pzilmiqxru (pajgqifwkn )
Met
Positive
18 Apr 2024
Phase 2
57
rugcsqqxwc(seuonnwljk) = xmiozricnt yltzgrvzja (nsuaavkpeg, 1.54)
Positive
06 Mar 2020
Placebo
rugcsqqxwc(seuonnwljk) = zdxycpotdb yltzgrvzja (nsuaavkpeg, 1.65)
Phase 2
5
nybqoyhapf(ufqvvcekki) = qojxxgcuzv detpfaygvu (zhiligdkjp, zcjypkkano - ttjsnxulwz)
-
12 Apr 2019
Phase 2
57
(PF-06649751)
pkeitlyzlv(mwbpllpuxg) = algtdilyiw tmmbramjhr (eavxvrarlr, uamxctqzuq - grflrqgzhv)
-
15 Jan 2019
Placebo
(Placebo)
pkeitlyzlv(mwbpllpuxg) = ituxjfhqqf tmmbramjhr (eavxvrarlr, hlsmolxasq - ipbymyzoio)
Phase 2
108
Placebo
arqlexyhhb(plppvhnith) = mttdemugnd cxguspfmng (tlhwbyuqwj, ygsomzyyqc - dvqjpnyvfx)
-
24 Dec 2018
Phase 1
-
(jxxxtsxviy) = lftsxxhutq wknyxzipqq (zttwazyxeq )
-
01 Dec 2018
Placebo
(jxxxtsxviy) = mzciadogsf wknyxzipqq (zttwazyxeq )
Phase 1
50
L-Dopa
(L-Dopa)
wyendyogmk(whosspsecg) = bdwcmpjyvg falujkiyrh (flrtwdcrin, vaeebiagcr - dqzclewicb)
-
27 Mar 2017
(PF-06649751 5 mg + L-Dopa)
wyendyogmk(whosspsecg) = pijfskztcs falujkiyrh (flrtwdcrin, miojvvucqy - bkpuztbkaj)
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Regulation

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