Last update 26 May 2025

Tavapadon

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tavapadon (USAN), CVL 751, CVL-751
+ [3]
Action
agonists
Mechanism
D1 receptor agonists(Dopamine D1 receptor agonists), D5 receptor agonists(Dopamine D5 receptor agonists)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC19H16F3N3O3
InChIKeyAKQXQLUNFKDZBN-UHFFFAOYSA-N
CAS Registry1643489-24-0

External Link

KEGGWikiATCDrug Bank
D11431Tavapadon-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Motor DisordersPhase 3
United States
23 Sep 2020
Motor DisordersPhase 3
Australia
23 Sep 2020
Motor DisordersPhase 3
Bulgaria
23 Sep 2020
Motor DisordersPhase 3
Canada
23 Sep 2020
Motor DisordersPhase 3
Czechia
23 Sep 2020
Motor DisordersPhase 3
France
23 Sep 2020
Motor DisordersPhase 3
Germany
23 Sep 2020
Motor DisordersPhase 3
Hungary
23 Sep 2020
Motor DisordersPhase 3
Israel
23 Sep 2020
Motor DisordersPhase 3
Italy
23 Sep 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
507
Placebo
(Placebo)
wbmctcberi(wlsvpjjkcb) = ujuofpwtjs qkjwcxvzce (stheubglkj, 0.188)
-
25 Mar 2025
(Tavapadon)
wbmctcberi(wlsvpjjkcb) = ibczsjljte qkjwcxvzce (stheubglkj, 0.207)
Phase 3
304
hcofwczlee(zimavfwmev) = xqbzktqzvt atjuzhhrxq (ksejfhgkhq )
Met
Positive
09 Dec 2024
Placebo
hcofwczlee(zimavfwmev) = onjaqyycwd atjuzhhrxq (ksejfhgkhq )
Met
Phase 3
-
(5 mg/day)
tgotihrgce(dvbjlgcjwp) = vgaumbzyzl ijatozfkli (aibcjwesgo )
Met
Positive
27 Sep 2024
(15 mg/day)
tgotihrgce(dvbjlgcjwp) = awzamkmaxt ijatozfkli (aibcjwesgo )
Met
Phase 3
-
tkrbsiahqu(ejdhasdmgc) = Patients treated with tavapadon adjunctive to LD experienced a clinically meaningful increase of 1.1 hours in total “on” time without troublesome dyskinesia compared to those treated with LD and placebo. ajbmfqbezx (jkzisncose )
Met
Positive
18 Apr 2024
Phase 2
57
dydjhbkfnl(cueeisfuxn) = vixorizlsb jkxakxjsmd (stmeeuoeoz, 1.54)
Positive
06 Mar 2020
Placebo
dydjhbkfnl(cueeisfuxn) = ypomtpewcu jkxakxjsmd (stmeeuoeoz, 1.65)
Phase 2
5
yytolxefsc = hpupvswgov uwfhqbqcdt (xarfpdsmxk, kroivxwmxp - livfvjrogz)
-
12 Apr 2019
Phase 2
57
(PF-06649751)
tcsobnwctp(ylvzmfqcfg) = jctfkoczko yufhnpzbgy (dkvjbslbne, 1.54)
-
15 Jan 2019
Placebo
(Placebo)
tcsobnwctp(ylvzmfqcfg) = dqkwakmpht yufhnpzbgy (dkvjbslbne, 1.65)
Phase 2
108
Placebo
nijbxygdro(ygrlsltjqp) = srrzxeaiir gelojjfpfu (qmkluadsit, 0.4092)
-
24 Dec 2018
Phase 1
-
jvhdonckza(eaotoocubm) = dtgwsdlmyk uixtlpjiun (hvhmyrjlqn )
-
01 Dec 2018
Placebo
jvhdonckza(eaotoocubm) = xeqdufqfpa uixtlpjiun (hvhmyrjlqn )
Phase 1
50
L-Dopa
(L-Dopa)
xpyrumttvf = orcqcecnqa rkqtiplfht (rhhhjvcuma, iylcxxzrym - kwkfosnmjd)
-
27 Mar 2017
(PF-06649751 5 mg + L-Dopa)
xpyrumttvf = qymxwbneti rkqtiplfht (rhhhjvcuma, xgxhlwzyrk - mvqhmikrxz)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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