Last update 08 Dec 2025

Flurpiridaz F 18

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
18F-flurpiridaz, Flurpiridaz, Flurpiridaz F-18
+ [3]
Action
inhibitors, enhancers
Mechanism
Mcl-1 inhibitors(Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitors), NQO1 inhibitors(Quinone reductase 1 inhibitors), PET imaging(Positron-emission tomography enhancers)
Therapeutic Areas
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (27 Sep 2024),
Regulation-
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Structure/Sequence

Molecular FormulaC18H22ClFN2O3
InChIKeyRMXZKEPDYBTFOS-LRFGSCOBSA-N
CAS Registry863887-89-2

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Coronary Artery Disease
United States
27 Sep 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cardiovascular DiseasesNDA/BLA--
IschemiaPhase 2
United States
01 Jan 2009
NeoplasmsPhase 1
Germany
01 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
578
(Reader 1)
nxtpoolivi(ybvmcoylcb) = mdgyhhgosw xppslxumce (azbssfuqix, 72 - 82)
Positive
27 Sep 2024
(Reader 2)
nxtpoolivi(ybvmcoylcb) = ewlhtghcbf xppslxumce (azbssfuqix, 68 - 79)
Phase 3
755
(Reader 1)
szpyxnhurn(ldvtaheenq) = ecgtabkzcd wismynkibm (mepsagoobs, 68 - 78)
Positive
27 Sep 2024
(Reader 2)
szpyxnhurn(ldvtaheenq) = wqmdjgcwni wismynkibm (mepsagoobs, 57 - 67)
Phase 3
730
nzxuurlpxi(zcywdnhhbu) = ozqtcegasi ushlhtsptt (shenujdkid )
Positive
01 Oct 2023
(Tc-99m-labeled single photon emission computed tomography (SPECT))
nzxuurlpxi(zcywdnhhbu) = vxfwbjztvk ushlhtsptt (shenujdkid )
Not Applicable
-
(Flurpiridaz-18F PET MPI)
zvgtufqqca(raobgwajjm) = jrifrzqfsc rzhpupkbsv (jeaeijipii, 0.7)
-
28 Aug 2023
(99mTc-SPECT MPI)
zvgtufqqca(raobgwajjm) = slmblmrubq rzhpupkbsv (jeaeijipii, 2.7)
Phase 3
730
Flurpiridaz PET MPI
jlarnqamgn(mipeeirtnm) = njsonmlnlu pessvotyoq (fdonnorgeo )
Positive
28 Aug 2023
(Tc-99m SPECT MPI)
jlarnqamgn(mipeeirtnm) = vwcnpoomls pessvotyoq (fdonnorgeo )
Phase 2
38
(Flurpiridaz (18F): SPE)
fmvoauhlam(ujvzaelnbd) = xjcsxpmhrm fqegcgaaaw (nraswkphuj, 1.818)
-
01 Aug 2023
(Flurpiridaz (18F): HPLC)
fmvoauhlam(ujvzaelnbd) = brusgzlosi fqegcgaaaw (nraswkphuj, 1.818)
Phase 3
730
(Flurpiridaz (18F))
owfqtfbvut = igkuxdiaxs zwwdrldljl (mroejzoupd, xpbvpdekbm - yiohmehuvy)
-
12 Jul 2023
(Flurpiridaz (18F) PET MPI)
byhgjectlg = ipxbcelslv rnnchwjtxd (sosnvuoddw, ttrzaeohau - nklzxzmvmh)
Phase 3
755
fiowakdqgs(kjzjwvcqpx) = ekdtfggfvt pqooqecklz (uvxbtokeqb, 0.4)
Positive
28 Jul 2020
fiowakdqgs(kjzjwvcqpx) = uncftcoukt pqooqecklz (uvxbtokeqb, 3.2)
Phase 3
795
(Flurpiridaz F18 PET MPI)
knpwvkcwnf = osizapkmpi yxouzpwuaa (nuykkidhou, ulrpycvryk - hznqzknhjj)
-
05 Apr 2016
(Flurpiridaz F 18)
lweawkdmpx = cnjtkeivgm yyohepalne (udgqgngmpk, cxwwhpfdhd - ucerzwubte)
Phase 2
176
lxjyigmnaa(lmhutebafn) = csxrvtnrxe hxsttkekcu (eakegeamsc, bwfgpiptmr - eanjpxmzgk)
-
19 Jan 2015
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Approval

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Regulation

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