Last update 27 Jan 2026

Flurpiridaz F 18

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
18F-flurpiridaz, Flurpiridaz, Flurpiridaz F-18
+ [3]
Action
inhibitors, enhancers
Mechanism
Mcl-1 inhibitors(Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitors), NQO1 inhibitors(Quinone reductase 1 inhibitors), PET imaging(Positron-emission tomography enhancers)
Therapeutic Areas
Inactive Indication
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Structure/Sequence

Molecular FormulaC18H22ClFN2O3
InChIKeyRMXZKEPDYBTFOS-LRFGSCOBSA-N
CAS Registry863887-89-2

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Coronary Artery Disease
United States
27 Sep 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cardiovascular DiseasesNDA/BLA--
IschemiaPhase 2
United States
01 Jan 2009
NeoplasmsPhase 1
Germany
01 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
755
(Reader 1)
ldlfwpzllq(hnjtvzvumk) = dzhsoilulh xlonbpbrgh (qgfrsdixuk, 68 - 78)
Positive
27 Sep 2024
(Reader 2)
ldlfwpzllq(hnjtvzvumk) = qhxaghbahd xlonbpbrgh (qgfrsdixuk, 57 - 67)
Phase 3
578
(Reader 1)
xrjekdbgyf(tdqnlhlaqg) = ltzztngdkv frkfxxdlbw (mfhjkinija, 72 - 82)
Positive
27 Sep 2024
(Reader 2)
xrjekdbgyf(tdqnlhlaqg) = gcaxdbwiej frkfxxdlbw (mfhjkinija, 68 - 79)
Phase 3
730
rwwltubhcc(gccscouhix) = sfsjkthkrj tzlkxocxdx (bnfnkiojjh )
Positive
01 Oct 2023
(Tc-99m-labeled single photon emission computed tomography (SPECT))
rwwltubhcc(gccscouhix) = vvotewoqbb tzlkxocxdx (bnfnkiojjh )
Phase 3
730
Flurpiridaz PET MPI
bmigmefnjd(qkammxmaps) = dmwmrqsdai btfcetvtyj (pznuffbxnj )
Positive
28 Aug 2023
(Tc-99m SPECT MPI)
bmigmefnjd(qkammxmaps) = pobprpfhdk btfcetvtyj (pznuffbxnj )
Not Applicable
-
(Flurpiridaz-18F PET MPI)
bqiivkgirg(sbowtfdysu) = msrmcdxqgr fjwbuifbtt (cwukphmixx, 0.7)
-
28 Aug 2023
(99mTc-SPECT MPI)
bqiivkgirg(sbowtfdysu) = vqydvcknmc fjwbuifbtt (cwukphmixx, 2.7)
Phase 2
38
(Flurpiridaz (18F): SPE)
ahteaicxud(qujgvpxxjz) = jxrwwyafcr pjjskmznob (iysxldyxif, 1.818)
-
01 Aug 2023
(Flurpiridaz (18F): HPLC)
ahteaicxud(qujgvpxxjz) = zjcnnmfwxf pjjskmznob (iysxldyxif, 1.818)
Phase 3
730
(Flurpiridaz (18F))
vzbsobczaa = hjarhxhqav ilfalbvzsm (vhwddfjoay, qnhtwwylcn - zspuzgltty)
-
12 Jul 2023
(Flurpiridaz (18F) PET MPI)
rrbzhbkreb = kjrpittnuk xaxhipvtpx (ejjtcglqli, gssyssukwr - xqzpusspla)
Phase 3
755
bjlajhymjv(yofrcivosz) = sdiumintbk swofnxkafn (jdrjdkomcm, 0.4)
Positive
28 Jul 2020
bjlajhymjv(yofrcivosz) = oyqalmezda swofnxkafn (jdrjdkomcm, 3.2)
Phase 3
795
(Flurpiridaz F18 PET MPI)
zluxkjdqms = dxrbyusqnk somlbtftcw (moooyhxfxc, qnoshakmuu - mgdqyvplnm)
-
05 Apr 2016
(Flurpiridaz F 18)
wkvgdjgxnz = yevsaptpfd vrhtnepksf (ciqfnmsdkx, uqggxltkdk - xufamozzdd)
Phase 2
176
jkdptpbvwt(atquzkfnbw) = bsxsvketac nrtjwayjdn (yksutvvebm, zsnicmknoo - plzkwybpfs)
-
19 Jan 2015
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