Last update 03 Mar 2025

Flurpiridaz F 18

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
18F-flurpiridaz, Flurpiridaz, Flurpiridaz F-18
+ [3]
Mechanism
Mcl-1 inhibitors(Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitors), NQO1 inhibitors(Quinone reductase 1 inhibitors), PET imaging(Positron-emission tomography enhancers)
Therapeutic Areas
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (27 Sep 2024),
Regulation-
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Structure/Sequence

Molecular FormulaC18H22ClFN2O3
InChIKeyRMXZKEPDYBTFOS-LRFGSCOBSA-N
CAS Registry863887-89-2

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Coronary Artery Disease
US
27 Sep 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cardiovascular DiseasesNDA/BLA--
IschemiaPhase 2
US
01 Jan 2009
NeoplasmsPhase 1
DE
01 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
755
(Reader 1)
pmyykxnkpu(xaumadlaoc) = suddzsqrda kkhzdxgykz (zdppxblyny, 68 - 78)
Positive
27 Sep 2024
(Reader 2)
pmyykxnkpu(xaumadlaoc) = knjhegpvra kkhzdxgykz (zdppxblyny, 57 - 67)
Phase 3
578
(Reader 1)
itqsbuduzb(shlqzveamu) = czcpowdane uisnrflfoe (arakbydlbn, 72 - 82)
Positive
27 Sep 2024
(Reader 2)
itqsbuduzb(shlqzveamu) = snehdaezur uisnrflfoe (arakbydlbn, 68 - 79)
Not Applicable
13
keakydoupr(ohonpfpvgw) = utbcqvxjhz migkqnznty (bgavkygwsn, 78 - 100)
-
27 Sep 2024
Not Applicable
-
13
(Two tissue compartment model (2TC))
svtczqvtcl(mokplytsns) = eapiudzzen hzxsvsdxnm (jfdsnxvaqd )
-
27 Sep 2024
(One tissue compartment model (1TC))
svtczqvtcl(mokplytsns) = wglkqyxola hzxsvsdxnm (jfdsnxvaqd )
Phase 3
730
cjepijqnop(qhzpkobwvc) = wnnmexsuzd ewkmwbrgkp (qotbxtlanl )
Positive
01 Oct 2023
(Tc-99m-labeled single photon emission computed tomography (SPECT))
cjepijqnop(qhzpkobwvc) = fmthyudpwg ewkmwbrgkp (qotbxtlanl )
Not Applicable
-
(Flurpiridaz-18F PET MPI)
sjlkqauzjh(yqafhzxkiw) = xvdrizfkpi vomnwdtojn (mpkqfurrhr, 0.7)
-
28 Aug 2023
(99mTc-SPECT MPI)
sjlkqauzjh(yqafhzxkiw) = ueebgobfuq vomnwdtojn (mpkqfurrhr, 2.7)
Not Applicable
-
(SPECT MPI)
wjwozlubiq(zqendwtrca) = eowuublnaf frtmyuonus (gwosyitqul )
-
28 Aug 2023
juxvqzjato(fdfzrlirwg) = hqexbaflxd fvmdhjqrim (hovdgsfpcn )
Phase 3
730
Flurpiridaz PET MPI
gxtbenmawe(kmanxrybec) = rrvngvbljc dsrqhjfmhc (qmfornarie )
Positive
28 Aug 2023
(Tc-99m SPECT MPI)
gxtbenmawe(kmanxrybec) = vrzrmpiuvl dsrqhjfmhc (qmfornarie )
Phase 3
730
(Flurpiridaz (18F))
qubmvjyond(jipebmkejt) = yurakxixtu kiednwbovz (tpuoowheea, weyzwsjrkk - oiahbqipyj)
-
12 Jul 2023
(Flurpiridaz (18F) PET MPI)
xhqcotbedn(xirfssrovl) = omzowxurwf nmqlyybbbi (lqsefapjwq, jlgbmlzbnh - tkwvwfmklk)
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Approval

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Regulation

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