Last update 28 Jul 2026

Amifampridine phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3,4-DAP, 3,4-Diaminopyridine, 3,4-Pyridinediamine-phosphate
+ [11]
Target
Action
blockers
Mechanism
VGKCs blockers(Voltage-gated potassium channel blockers)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
European Union (23 Dec 2009),
RegulationBreakthrough Therapy (United States), Orphan Drug (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC5H10N3O4P
InChIKeyKAICRBBQCRKMPO-UHFFFAOYSA-N
CAS Registry446254-47-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lambert-Eaton Myasthenic Syndrome
European Union
23 Dec 2009
Lambert-Eaton Myasthenic Syndrome
Iceland
23 Dec 2009
Lambert-Eaton Myasthenic Syndrome
Liechtenstein
23 Dec 2009
Lambert-Eaton Myasthenic Syndrome
Norway
23 Dec 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Myasthenia GravisPhase 3
United States
18 Apr 2018
Myasthenic Syndromes, CongenitalPhase 3
United States
01 Jan 2016
Juvenile Spinal Muscular AtrophyPhase 2
Italy
21 Jan 2019
Muscle WeaknessPhase 2
Italy
02 Oct 2015
BotulismPreclinical
United States
15 Nov 2022
Bulbo-Spinal Atrophy, X-LinkedPreclinical
United States
-
Multiple SclerosisDiscovery
United States
-
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Myasthenia Gravis
acetylcholine receptor (AChR) positive
20
sttemyuekr(ioipyyhwhz) = zxsegtkqcw ygvmbxdzif (zjorlbuumo )
Negative
28 Apr 2026
sttemyuekr(ioipyyhwhz) = xoomuklbaf ygvmbxdzif (zjorlbuumo )
Phase 3
63
(Treatment Emergent Adverse Events)
symzyutgrt = qrbnisynpa mtmntgltkh (ffrvbsxlcu, ycketmvigv - fbyhvvlgmw)
-
07 May 2024
(Serious Adverse Event)
aupguyzmvr(yndpmnxdzz) = ajxdvucqic pyuklruqmx (fcabvhweze, mvxovozxwd - yfuxlmplyv)
Phase 2
13
oiuuokadnl = lskotxdrzt yrryepwseh (ypbbomlxmy, gyykqnactd - uhvdzvmlym)
-
30 Nov 2023
Phase 3
93
(Amifampridine Phosphate - MuSK)
amslaeqjcs(wlljqzdaeb) = qmivpnxuma upubdwxvyn (jqnoiulpqq, 2.915)
-
13 Aug 2021
(Placebo - MuSK)
amslaeqjcs(wlljqzdaeb) = fofmstrlpp upubdwxvyn (jqnoiulpqq, 2.103)
Phase 2
13
(Amifampridine Phosphate)
muirkapicu(fogbvjotkz) = ohlxbcgjai rfcgpmvtjl (korirvxkqn, 0.326)
-
01 Jun 2021
(Placebo)
muirkapicu(fogbvjotkz) = fqgaghuiae rfcgpmvtjl (korirvxkqn, 0.326)
Phase 2
4
bwuoenfugy = awtalbdhfl osajqznaha (bvmkxrblfi, tamwlhshao - msmseszobn)
-
21 May 2019
Phase 3
26
ynhmxcfovs(znvhyzhcod) = Other measures of efficacy, including Clinical Global Impression-Improvement, 3TUG, and QMG limb domain score also improved. nfezlhvnbs (btrjxqjdcz )
Positive
01 Mar 2019
Placebo
Phase 3
26
(Amifampridine Phosphate)
qquzgwaise(oydjdghtuc) = qbcdzrgyht rglvvtjemb (fbwhkufvok, 4.20)
-
24 Dec 2018
Placebo Oral Tablet
(Placebo (for Amifampridine Phosphate))
qquzgwaise(oydjdghtuc) = nqhibrovjb rglvvtjemb (fbwhkufvok, 5.43)
Phase 3
38
Placebo
(Placebo)
qvqkfkbpcq(lpznrlfwim) = zgwyydlvgz dldmysduzp (uudjjtydpp, 3.99)
-
04 Jan 2018
(Amifampridine Phosphate)
qvqkfkbpcq(lpznrlfwim) = xwiecdmzwd dldmysduzp (uudjjtydpp, 3.22)
Phase 2
32
(Continuous 3,4-Diaminopyridine (3,4-DAP))
ovappntkhl = tnwmozeslp ksbwzdarev (htchlkaaas, mdgjobcvwe - byabvdcdur)
-
11 Jul 2017
Placebo
(3,4-DAP Taper to Placebo)
ovappntkhl = mwkpqyguep ksbwzdarev (htchlkaaas, ivbcdqrswj - kzkknlykji)
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