Drug Type Small molecule drug |
Synonyms 3,4-DAP, 3,4-Diaminopyridine, 3,4-Pyridinediamine-phosphate + [11] |
Target |
Action blockers |
Mechanism VGKCs blockers(Voltage-gated potassium channel blockers) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date European Union (23 Dec 2009), |
RegulationBreakthrough Therapy (United States), Orphan Drug (United States), Orphan Drug (Japan) |
Molecular FormulaC5H10N3O4P |
InChIKeyKAICRBBQCRKMPO-UHFFFAOYSA-N |
CAS Registry446254-47-3 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D10689 | Amifampridine phosphate |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Myasthenia Gravis | Phase 3 | United States | 18 Apr 2018 | |
| Myasthenic Syndromes, Congenital | Phase 3 | United States | 01 Jan 2016 | |
| Juvenile Spinal Muscular Atrophy | Phase 2 | Italy | 21 Jan 2019 | |
| Muscle Weakness | Phase 2 | Italy | 02 Oct 2015 | |
| Botulism | Preclinical | United States | 15 Nov 2022 | |
| Bulbo-Spinal Atrophy, X-Linked | Preclinical | United States | - | |
| Multiple Sclerosis | Discovery | United States | - |
Phase 2 | Myasthenia Gravis acetylcholine receptor (AChR) positive | 20 | sttemyuekr(ioipyyhwhz) = zxsegtkqcw ygvmbxdzif (zjorlbuumo ) View more | Negative | 28 Apr 2026 | ||
sttemyuekr(ioipyyhwhz) = xoomuklbaf ygvmbxdzif (zjorlbuumo ) View more | |||||||
Phase 3 | 63 | (Treatment Emergent Adverse Events) | symzyutgrt = qrbnisynpa mtmntgltkh (ffrvbsxlcu, ycketmvigv - fbyhvvlgmw) | - | 07 May 2024 | ||
(Serious Adverse Event) | aupguyzmvr(yndpmnxdzz) = ajxdvucqic pyuklruqmx (fcabvhweze, mvxovozxwd - yfuxlmplyv) View more | ||||||
Phase 2 | 13 | oiuuokadnl = lskotxdrzt yrryepwseh (ypbbomlxmy, gyykqnactd - uhvdzvmlym) View more | - | 30 Nov 2023 | |||
Phase 3 | 93 | (Amifampridine Phosphate - MuSK) | amslaeqjcs(wlljqzdaeb) = qmivpnxuma upubdwxvyn (jqnoiulpqq, 2.915) View more | - | 13 Aug 2021 | ||
Placebo+amifampridine phosphate (Placebo - MuSK) | amslaeqjcs(wlljqzdaeb) = fofmstrlpp upubdwxvyn (jqnoiulpqq, 2.103) View more | ||||||
Phase 2 | 13 | (Amifampridine Phosphate) | muirkapicu(fogbvjotkz) = ohlxbcgjai rfcgpmvtjl (korirvxkqn, 0.326) | - | 01 Jun 2021 | ||
placebo+amifampridine (Placebo) | muirkapicu(fogbvjotkz) = fqgaghuiae rfcgpmvtjl (korirvxkqn, 0.326) View more | ||||||
Phase 2 | 4 | bwuoenfugy = awtalbdhfl osajqznaha (bvmkxrblfi, tamwlhshao - msmseszobn) View more | - | 21 May 2019 | |||
NCT02970162 (Pubmed) Manual | Phase 3 | 26 | ynhmxcfovs(znvhyzhcod) = Other measures of efficacy, including Clinical Global Impression-Improvement, 3TUG, and QMG limb domain score also improved. nfezlhvnbs (btrjxqjdcz ) View more | Positive | 01 Mar 2019 | ||
Placebo | |||||||
Phase 3 | 26 | (Amifampridine Phosphate) | qquzgwaise(oydjdghtuc) = qbcdzrgyht rglvvtjemb (fbwhkufvok, 4.20) View more | - | 24 Dec 2018 | ||
Placebo Oral Tablet (Placebo (for Amifampridine Phosphate)) | qquzgwaise(oydjdghtuc) = nqhibrovjb rglvvtjemb (fbwhkufvok, 5.43) View more | ||||||
Phase 3 | 38 | Placebo (Placebo) | qvqkfkbpcq(lpznrlfwim) = zgwyydlvgz dldmysduzp (uudjjtydpp, 3.99) View more | - | 04 Jan 2018 | ||
(Amifampridine Phosphate) | qvqkfkbpcq(lpznrlfwim) = xwiecdmzwd dldmysduzp (uudjjtydpp, 3.22) View more | ||||||
Phase 2 | 32 | (Continuous 3,4-Diaminopyridine (3,4-DAP)) | ovappntkhl = tnwmozeslp ksbwzdarev (htchlkaaas, mdgjobcvwe - byabvdcdur) View more | - | 11 Jul 2017 | ||
Placebo (3,4-DAP Taper to Placebo) | ovappntkhl = mwkpqyguep ksbwzdarev (htchlkaaas, ivbcdqrswj - kzkknlykji) View more |





