Last update 07 Nov 2024

Irpagratinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ABSK 011, ABSK-011
Target
Mechanism
FGFR4 antagonists(Fibroblast growth factor receptor 4 antagonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC28H32F2N6O5
InChIKeyPGRHEHZIRYNZDV-FUHWJXTLSA-N
CAS Registry2230974-62-4

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatocellular CarcinomaPhase 2
CN
30 Dec 2021
Advanced Hepatocellular CarcinomaPhase 1
CN
26 Feb 2020
Advanced Malignant Solid NeoplasmPhase 1
CN
26 Feb 2020
FGFR4 positive Solid TumorsIND Approval
CN
19 Sep 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
Advanced Hepatocellular Carcinoma
Second line
FGF19 overexpression
109
ovetdfmxeb(zugivdoccf) = most common (>20%) were alanine aminotransferase (ALT) increased (70.6%), diarrhea (67.9%), aspartate aminotransferase (AST) increased (56.9%), hyperphosphataemia (37.6%), bilirubin increased (35.8%), total bile acids increased (21.1%) and alkaline phosphatase increased (20.2%). Majority of TRAEs were Gr 1-2 and reversible/manageable. pjxrhpisgq (yhlropkmbd )
Positive
16 Sep 2024
Phase 1
75
oquyhoonct(kcjyvkzjjt) = lzsencruop vdnaqcbqun (tfdblngqlu )
Positive
23 Oct 2023
ABSK-011 400 mg QD
sqcyisvohq(eytoqgzkln) = mhbqkiowtn pjrtiubmln (frxqjxfcam )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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