Last update 21 Nov 2025

Deutetrabenazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
d6-tetrabenazine, deuterated tetrabenazine analog, Deuterium-substituted tetrabenazine
+ [12]
Target
Action
inhibitors
Mechanism
VMAT2 inhibitors(Synaptic vesicular amine transporter inhibitors)
Drug Highest PhaseApproved
First Approval Date
United States (03 Apr 2017),
RegulationBreakthrough Therapy (United States), Orphan Drug (United States), Priority Review (China), Orphan Drug (South Korea), Overseas New Drugs Urgently Needed in Clinical Settings (China)
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Structure/Sequence

Molecular FormulaC19H27NO3
InChIKeyMKJIEFSOBYUXJB-QBUQIWBYSA-N
CAS Registry1392826-25-3

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Chorea
China
08 Jun 2020
Tardive Dyskinesia
United States
30 Aug 2017
Huntington Disease
United States
03 Apr 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cerebral PalsyPhase 3
United States
06 Aug 2019
Cerebral PalsyPhase 3
Belgium
06 Aug 2019
Cerebral PalsyPhase 3
Canada
06 Aug 2019
Cerebral PalsyPhase 3
Denmark
06 Aug 2019
Cerebral PalsyPhase 3
Israel
06 Aug 2019
Cerebral PalsyPhase 3
Italy
06 Aug 2019
Cerebral PalsyPhase 3
Poland
06 Aug 2019
Cerebral PalsyPhase 3
Russia
06 Aug 2019
Cerebral PalsyPhase 3
Slovakia
06 Aug 2019
Cerebral PalsyPhase 3
Spain
06 Aug 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
53
tyodkwgvcx(fpfetyfcaz) = lavvrdcbkv vnkwcbcelg (qtpijpmlxl )
Positive
05 Oct 2025
(Black/Pacific Islander)
smtptwhzwg(kvhfpslbfh) = kgosblpuwc vaoijrtvhy (lmcgotxeus )
Not Applicable
154
(rollover cohort patients)
rgwbbsethu(cfhdejayju) = AEs including falls (38% RC, 43% SC), depression (32%, 22%), anxiety (27%, 35%), insomnia (23%, 16%), somnolence (20%, 30%), and akathisia (6%, 11%). Less frequent AEs included suicidality (9%, 5%) and parkinsonism (4%, 8%) (Frank et al., 2022). xvekokjcvi (qbtrfejyav )
Positive
05 Oct 2025
(switch cohort patients)
Phase 3
-
nsqtigtlzs(fvthdbsjft) = vvcqmaonjp elkjinpjro (zsvuyloeds )
Positive
23 Sep 2024
Placebo
-
Phase 3
80
kunxdehhns(nnpyzxtoxs) = ylsplhrjok uvqsjfazbi (znpgccqaoz )
Positive
28 Jun 2024
Not Applicable
-
vkjpmwjpyj(bsyaocswfi) = ipqvtrklfj omkqsrkhog (ppnevnzixj )
Positive
01 Jun 2024
Placebo
vkjpmwjpyj(bsyaocswfi) = grtnmyvpfj omkqsrkhog (ppnevnzixj )
Phase 3
44
szlbzdjkhh = igvkoostun hjynavvuuw (geqlhbjpoo, dhibbmrpbt - lgfsxlhzbb)
-
22 Apr 2024
Not Applicable
-
ubpwewzaaa(ddfpkqjlna) = yzrtbidlcv ckqwpdiepa (kbskxqgfmt, 6)
-
09 Apr 2024
Phase 4
-
izmvsphugl(txpplmypip) = cfyiqwoceq qdbdgxmdao (zyrsmwnslu )
Positive
02 Nov 2023
Phase 3
63
Placebo
(Placebo)
absmqadsqj(pzeauujncx) = qgjcczmxnq qnfswaderb (lxkximjulx, 1.09)
-
08 Sep 2023
(TEV-50717)
absmqadsqj(pzeauujncx) = vnkvloxdzd qnfswaderb (lxkximjulx, 0.88)
FDA
ManualManual
Not Applicable
222
tmqtefpham(iudguhcnde) = vbuxoskqzu bnshishwcu (uzffbznjhl, 0.42)
Positive
17 Feb 2023
tmqtefpham(iudguhcnde) = kxxnycmozo bnshishwcu (uzffbznjhl, 0.45)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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