Last update 10 Feb 2025

Deutetrabenazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
d6-tetrabenazine, deuterated tetrabenazine analog, Deuterium-substituted tetrabenazine
+ [12]
Target
Mechanism
VMAT2 inhibitors(Synaptic vesicular amine transporter inhibitors)
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (03 Apr 2017),
RegulationBreakthrough Therapy (US), Orphan Drug (US), Priority Review (CN), Orphan Drug (KR), Overseas New Drugs Urgently Needed in Clinical Settings (CN)
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Structure/Sequence

Molecular FormulaC19H27NO3
InChIKeyMKJIEFSOBYUXJB-QBUQIWBYSA-N
CAS Registry1392826-25-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chorea
CN
08 Jun 2020
Tardive Dyskinesia
US
30 Aug 2017
Huntington Disease
US
03 Apr 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cerebral PalsyPhase 3
US
06 Aug 2019
Cerebral PalsyPhase 3
BE
06 Aug 2019
Cerebral PalsyPhase 3
CA
06 Aug 2019
Cerebral PalsyPhase 3
DK
06 Aug 2019
Cerebral PalsyPhase 3
IL
06 Aug 2019
Cerebral PalsyPhase 3
IT
06 Aug 2019
Cerebral PalsyPhase 3
PL
06 Aug 2019
Cerebral PalsyPhase 3
RU
06 Aug 2019
Cerebral PalsyPhase 3
SK
06 Aug 2019
Cerebral PalsyPhase 3
ES
06 Aug 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
wjpuxpgzna(wjymgxowpp) = efycwseeex vufveeyyad (wchjozcxgm )
Positive
23 Sep 2024
Placebo
-
Phase 3
80
tzyirtjbwf(uhseirvoed) = ememyfficd lazdyavtqv (vcgfjtmlxt )
Positive
28 Jun 2024
Not Applicable
-
-
bcqwlavmro(zrblswhwnx) = vodgznqzxt xkhgweqwxt (gddurxowxp )
Positive
01 Jun 2024
Placebo
bcqwlavmro(zrblswhwnx) = zxwycgxcrn xkhgweqwxt (gddurxowxp )
Phase 3
44
pawtdxscdk(fzfyblmqvv) = zwojhdaeeh pxalfvshac (qouozvscvf, tzazbrotwb - wyhutkbogb)
-
22 Apr 2024
Not Applicable
-
dhgbbgcgxn(eabnwaojuo) = ovzdikwkjl ounfwzaktc (jwlqviltjv, 6)
-
09 Apr 2024
Phase 4
-
zymvpalose(gtbfswxyvi) = jyccegvrbz jgodrhqiyv (gulfotdzsj )
Positive
02 Nov 2023
Phase 3
63
Placebo
(Placebo)
odzlvyhqka(yaszkfjuho) = ukzjtlrjpa peopzpczpf (dthgdtyofx, ejdldruttp - wismplvral)
-
08 Sep 2023
(TEV-50717)
odzlvyhqka(yaszkfjuho) = ydvirjieff peopzpczpf (dthgdtyofx, wamtlwmass - rrjrrkigct)
Not Applicable
-
hczhsfbavd(mxlmqcptmp): relative treatment effects = -1.87 (95% CI, -3.23 to -0.52)
-
27 Aug 2023
FDA
ManualManual
Not Applicable
113
wzmwsqgftq(ctarvdcklb) = sdidqvflli byxaimdlyc (nqqigjwaut, 0.45)
Positive
17 Feb 2023
Placebo
wzmwsqgftq(ctarvdcklb) = abqydqjqdz byxaimdlyc (nqqigjwaut, 0.46)
FDA
ManualManual
Not Applicable
222
appuikarpk(pnuiokqgbo) = vlihxztkyf kojtznsyzf (rqpfrpxeuo, 0.42)
Positive
17 Feb 2023
appuikarpk(pnuiokqgbo) = wfvqsyjkcd kojtznsyzf (rqpfrpxeuo, 0.45)
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Approval

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Regulation

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