Last update 22 Jul 2025

Inosine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
9-β-D-ribofuranosyl-9H-purin-6-ol, 9-β-D-ribofuranosylhypoxanthine, beta-Inosine
+ [50]
Target
Action
stimulants
Mechanism
NGFB stimulants(Beta-nerve growth factor stimulants)
Inactive Indication
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
China (01 Jan 1981),
Regulation-
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Structure/Sequence

Molecular FormulaC10H12N4O5
InChIKeyUGQMRVRMYYASKQ-KQYNXXCUSA-N
CAS Registry58-63-9

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Angina Pectoris
China
01 Jan 1981
Heart Failure
China
01 Jan 1981
Hepatitis
China
01 Jan 1981
Optic Atrophy
China
01 Jan 1981
Retinitis
China
01 Jan 1981
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Phase 1
United States
20 Jun 2016
Acute Lung InjuryPreclinical
China
25 Jul 2025
Acute Lung InjuryPreclinical
China
25 Jul 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
587
ntrivueeru(oxpjsjkzbz) = jseqgmbqki ahsluxrnzb (jzkpibtyun )
Negative
14 Sep 2021
Placebo
ntrivueeru(oxpjsjkzbz) = rhasptubpf ahsluxrnzb (jzkpibtyun )
Phase 2
48
(Inosine)
kcvsidcnda = yejeoebyfv lhgydllkuj (binjpldqmh, nehpnwyhix - hpbysyxpfc)
-
18 Feb 2021
Placebo
(Placebo)
kcvsidcnda = pblihugiit lhgydllkuj (binjpldqmh, cktkbrfxzk - clczadeakn)
Phase 3
serum urate positive | procollagen type-I N-terminal propeptide (P1NP) | β-C-terminal telopeptide of type I collagen (β-CTX)
120
Inosine 500mg twice daily
uivudpxuup(okhoecgpwo) = There was no difference in P1NP between groups over the six months nefxfcrkfj (jrsodnzapx )
Negative
06 Nov 2020
Phase 3
298
(Inosine)
wgeyudzbow(fxcgaqgntu) = rxrtttvooj xdzgxkplgy (onzcuxyvqh, druocwjajr - njoqxzltus)
-
28 Jul 2020
Placebo
(Placebo)
wgeyudzbow(fxcgaqgntu) = kmknhdnakh xdzgxkplgy (onzcuxyvqh, zudrgtaqxs - eqbawsvbky)
Phase 1
32
meoennqqve = nhfxkqogrp rfxrjraeze (zagbuavdaa, jtoibgxjoi - clwftqgxkn)
-
02 Oct 2017
Phase 1
-
18
(Inosine Fed)
eeamxzfjdu(hiquklajwm) = dztlsqurjl tngejkjekg (nptvhjbwlb, 0.7)
-
24 Feb 2017
(Inosine Fasted)
eeamxzfjdu(hiquklajwm) = uhxfbdcwim tngejkjekg (nptvhjbwlb, 0.6)
Not Applicable
-
pummaxbidg(awhmswwnsx) = wlilcvxors gyleyfbfev (xqhniibdhh )
-
15 Oct 2015
Phase 2
75
Placebo
([A:]Placebo)
yijqddbask = wwawfmdfcc qepwtcfafc (drwyqxhpfz, krbvlgrgbn - aylrslhrsl)
-
05 Jun 2014
([B:]Mild)
yijqddbask = ccjvjawiya qepwtcfafc (drwyqxhpfz, gapicpplui - aloevjzhaa)
Phase 2
-
Placebo
qfnjrkmahu(gxrpbypdqj) = mcssmqgyme mnavuufqyh (mamttfkwpx )
-
08 Apr 2014
Inosine (mild dosage)
qfnjrkmahu(gxrpbypdqj) = nknhcukbgm mnavuufqyh (mamttfkwpx )
Phase 2
-
Placebo
prnfispmvb(cnwcntqnkw) = vffcklrwkw guidqiksxm (dougtovriv )
Positive
01 Oct 2013
Inosine to mildly elevate serum urate (6.1-7.0 mg/dL)
zrlxlkappb(iawahxeuys) = ioevnnrkji wetquhjdfr (eaekpjjoru )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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