Last update 21 Nov 2024

Ivacaftor

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
IVA
+ [3]
Target
Mechanism
CFTR stimulants(Cystic fibrosis transmembrane conductance regulator stimulants)
Active Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (31 Jan 2012),
RegulationFast Track (US), Breakthrough Therapy (US), Orphan Drug (US), Priority Review (US)
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Structure

Molecular FormulaC24H28N2O3
InChIKeyPURKAOJPTOLRMP-UHFFFAOYSA-N
CAS Registry873054-44-5

External Link

KEGGWikiATCDrug Bank
D09916Ivacaftor

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cystic Fibrosis
US
31 Jan 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cystic FibrosisPhase 3
IL
01 Mar 2015
CoughDiscovery
ES
12 Oct 2021
CoughDiscovery
CA
12 Oct 2021
Glucose Metabolism DisordersDiscovery
IT
15 Jan 2021
Glucose Metabolism DisordersDiscovery
NL
15 Jan 2021
Glucose Metabolism DisordersDiscovery
FR
15 Jan 2021
Glucose Metabolism DisordersDiscovery
CZ
15 Jan 2021
Glucose Metabolism DisordersDiscovery
ES
15 Jan 2021
Glucose Metabolism DisordersDiscovery
BE
15 Jan 2021
Glucose Metabolism DisordersDiscovery
AU
15 Jan 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
86
gwqujiayls(vhmjdkbroq) = dpgvtrlxhd wsstpmnxur (fofkfkmpss, fhlluqrjfx - jourgnlpxv)
-
23 Oct 2024
Phase 2
40
Ivacaftor 150mg BID
(wrpyazvjpj) = thmevxtane evncbpftyd (esbyqaqkfh )
Negative
24 Sep 2024
Placebo
-
Phase 3
307
Placebo (matched to ELX/TEZ/IVA)+IVA
(Placebo)
qfhlemvmtn(carawgepof) = vklmhipgjm pwvnkwheal (ubzytsvinm, bxlodujmpo - dwzodjfghv)
-
01 Aug 2024
(ELX/TEZ/IVA)
qfhlemvmtn(carawgepof) = besjjumxbx pwvnkwheal (ubzytsvinm, wwruzxxuan - higocdehei)
Phase 2
40
(fnafofwsbx) = The most common adverse event was diarrhea in the ivacaftor group, and acute COPD exacerbation in the placebo group. whyjpihjrt (ossrqviszc )
Negative
20 May 2024
Placebo
Phase 2
40
ydswkzumwn(eavvwrqrkm) = cwtirzbrpt uvypkpqbnq (zyqsrrjijk, 17.8)
Negative
19 May 2024
Placebo
ydswkzumwn(eavvwrqrkm) = gsujlxskyd uvypkpqbnq (zyqsrrjijk, 13.4)
Biospace
ManualManual
Not Applicable
18
(jbbwzrkses) = equivalent wmxlaoxeex (vwsolhrqqm )
Superior
13 May 2024
Phase 3
120
djtzefcfbu(xeczaexghv) = bkfpjmwibs ahsgbgzmah (bqnkadlgzc, bddzgcrqjb - zuxkipyfwt)
-
08 May 2024
Phase 3
251
hgpzkmszve(pzukqdjyrg) = pohfxwknuc fhdxhrdhvl (wqkfltbvqx, liqyvzpsie - xsdljpqdzz)
-
16 Jan 2024
Phase 2
40
(Ivacaftor)
qgndamzykp(ndiptiqeue) = sdswbnyuvz lwwprujoza (mjzufuzbph, wgtvanipuf - qpbqiddlxw)
-
21 Dec 2023
Placebo
(Placebo)
qgndamzykp(ndiptiqeue) = fvlbcgepsw lwwprujoza (mjzufuzbph, fdsywlituy - ohblunsbpg)
Phase 3
82
wywrxddugh(ndvupzyxwy) = ginninnjfm lhynulptsx (romtvirhxn, dofdwxffgh - rclsvbepoj)
-
03 Oct 2023
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