A phase III, multi-center, double-blind, randomized, vehicle controlled trial in a parallel-group design to evaluate the efficacy and safety of two formulations of Muxan containing 0.5 % or 1 % chloramine-T compared to vehicle in patients aged 12 years or older with acute herpes labialis

Start Date12 Jan 2011

Sponsor / Collaborator

Engelhard Arzneimittel GmbH & Co. KG

100 Clinical Results associated with Chloramine T

100 Translational Medicine associated with Chloramine T

100 Patents (Medical) associated with Chloramine T

3,496

Literatures (Medical) associated with Chloramine T

01 Mar 2025·Synlett

Attempts on Fluorinative Transformation of Selected Functionalized Cycloalkene Scaffolds through Aziridination/Aziridine-Opening Protocol

Author: Kiss, Loránd ; Gömöry, Ágnes ; Novák, Tamás T. ; Han, Jianlin ; Novak, Tamas T. ; Nonn, Melinda ; Nonn, Melinda ; Kiss, Lorand ; Gomory, Agnes ; Han, Jianlin

AbstractStudies on the transformations of some functionalized cycloalkene derivatives through their ring olefin-bond aziridination/aziridine opening with fluoride are presented. The selected model compounds submitted to fluorinative functionalization were an amino ester and diesters with a cyclohexene skeleton as well as a cyclopentene-fused β-lactam. Functionalization proceeded across a substrate-directed diastereoselective olefin-bond aziridination, followed by fluoride-mediated aziridine opening or intramolecular lactonization giving some fluorinated amino ester or amino lactone derivatives.

24 Feb 2025·European Journal of Organic Chemistry

Alkynyl Phenyl Selenides as Intermediates in the Metal‐Free Cyclisation of N‐Tosyl Homopropargyl Amides to γ‐Lactams

Author: Santoro, Stefano ; Vaccaro, Luigi ; Temperini, Andrea ; Brufani, Giulia

AbstractIn this work, we present an efficient Brønsted acid‐catalysed intramolecular hydroamination reaction of homopropargyl N‐tosyl amides to produce synthetically useful substituted γ‐lactams through the corresponding alkynyl phenyl selenide intermediates. Our focus on optimising the cyclisation protocol under flow conditions has led to a significant enhancement in efficiency, thereby reducing the time and resources required for the process. DFT calculations of the reaction mechanism for the catalytic transformation of a model alkynyl phenyl selenide were also conducted.

22 Jan 2025·Journal of the American Chemical Society

Dynamic Kinetic Activation of Aziridines Enables Radical-Polar Crossover (4 + 3) Cycloaddition with 1,3-Dienes

Article

Author: Wang, Gang-Wei ; Yang, Shang-Dong ; Yue, Qian ; Zhou, Pan-Pan ; Sun, Hao-Zheng ; Xie, Dong ; Wang, Lei

The cycloaddition of aziridines with unsaturated compounds is a valuable method for synthesizing nitrogen heterocycles. However, this process is predominantly substrate-controlled, posing significant challenges in regulating the regioselectivity of the C-N bond cleavage. In this study, we report a nickel-catalyzed dynamic kinetic activation strategy that enables catalyst-controlled activation of aziridines. Various types of aziridines, including 2-phenyl, 2-carbonyl, 2-alkyl, and disubstituted aziridines, consistently cleave their more sterically hindered C-N bonds to generate 1,3-radical anion intermediates. These intermediates participate in a highly regioselective 1,4-Heck/allylic substitution cascade with aromatic branched 1,3-dienes, resulting in a radical-polar crossover (4 + 3) cycloaddition that produces seven-membered azepine products. This approach not only complements traditional dipolar cycloaddition, in which aziridines typically act as zwitterionic 1,3-dipoles, but also introduces an unusual cycloaddition mode for 1,3-dienes. Experimental investigations and density functional theory (DFT) calculations provide insight into the reaction mechanism.

100 Deals associated with Chloramine T

External Link

KEGG	Wiki	ATC	Drug Bank
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R&D Status

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Indication	Country/Location	Organization	Date
Herpes Labialis	Germany	Engelhard Arzneimittel GmbH & Co. KG	20 Dec 2007

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


SNMMI2020	Not Applicable	-	-	Chloramine-T (MAb-B10 conjugate)	oulswjhkgv(hnrjlxoosv) = umpuweuqil kpdswrkpmf (pinpkgpmys )	-	15 May 2020

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