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Last update 23 Oct 2025
Atigotatug/Nivolumab
Last update 23 Oct 2025
Overview
Basic Info
Drug Type Monoclonal antibody |
Synonyms BMS-986012/Nivolumab, BMS-986489 |
Target |
Action inhibitors |
Mechanism Fuc-GM1 inhibitors(Ganglioside fucosyl GM1 inhibitors), PD-1 inhibitors(Programmed cell death protein 1 inhibitors) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (United States) |
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Structure/Sequence
Sequence Code 93681H
The sequence is quoted from: *****
Sequence Code 93684L
The sequence is quoted from: *****
Sequence Code 97142L
The sequence is quoted from: *****
Sequence Code 936772904H
The sequence is quoted from: *****
Related
3
Clinical Trials associated with Atigotatug/NivolumabNCT06799286
An Open-label, Single-arm, Multicenter, Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of BMS-986489 (BMS-986012 + Nivolumab Fixed Dose Combination) in Chinese Participants With Relapsed/Refractory Small Cell Lung Cancer
NCT06773910
An Open-label, Randomized Study of BMS-986489 (Atigotatug + Nivolumab Fixed-dose Combination) vs Durvalumab as Consolidation Therapy Following Chemoradiotherapy in Limited-stage Small-cell Lung Cancer (TIGOS-LS)
NCT06646276
A Randomized, Double Blind, Multicenter Phase 3 Trial of BMS-986489 (BMS-986012+Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide vs Atezolizumab in Combination With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
100 Clinical Results associated with Atigotatug/Nivolumab
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100 Translational Medicine associated with Atigotatug/Nivolumab
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100 Patents (Medical) associated with Atigotatug/Nivolumab
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100 Deals associated with Atigotatug/Nivolumab
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Extensive stage Small Cell Lung Cancer | Phase 3 | United States | 25 Feb 2025 | |
| Extensive stage Small Cell Lung Cancer | Phase 3 | China | 25 Feb 2025 | |
| Extensive stage Small Cell Lung Cancer | Phase 3 | Japan | 25 Feb 2025 | |
| Extensive stage Small Cell Lung Cancer | Phase 3 | Argentina | 25 Feb 2025 | |
| Extensive stage Small Cell Lung Cancer | Phase 3 | Australia | 25 Feb 2025 | |
| Extensive stage Small Cell Lung Cancer | Phase 3 | Austria | 25 Feb 2025 | |
| Extensive stage Small Cell Lung Cancer | Phase 3 | Belgium | 25 Feb 2025 | |
| Extensive stage Small Cell Lung Cancer | Phase 3 | Brazil | 25 Feb 2025 | |
| Extensive stage Small Cell Lung Cancer | Phase 3 | Canada | 25 Feb 2025 | |
| Extensive stage Small Cell Lung Cancer | Phase 3 | Chile | 25 Feb 2025 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 2 | 250 | kwismlrdmt(nmccbvuhnp) = bhgarntbil hpiwcdzxlr (wlvmpwtizt, 11.3 - NE) | Positive | 30 May 2025 | |||
kwismlrdmt(nmccbvuhnp) = rvgabfvsof hpiwcdzxlr (wlvmpwtizt, 9.3 - 16.5) |
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Biosimilar
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