Last update 20 Mar 2025

SAMARIUM SM-153 LEXIDRONAM PENTASODIUM

Overview

Basic Info

Drug Type
Small molecule drug, Therapeutic radiopharmaceuticals
Synonyms
Samarium (153Sm) lexidronam pentasodium, Samarium-153 EDTMP, samarium [153Sm] lexidronam pentasodium
+ [5]
Action
stimulants
Mechanism
Reactive oxygen species stimulants, Ionising radiation emitters
Active Indication
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
United States (28 Mar 1997),
Regulation-
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Structure/Sequence

Molecular FormulaC6H12N2Na5O12P4Sm
InChIKeySZZACTGRBZTAKY-NKNBZPHVSA-F
CAS Registry176669-18-4

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Ostealgia
European Union
04 Feb 1998
Ostealgia
Iceland
04 Feb 1998
Ostealgia
Norway
04 Feb 1998
Ostealgia
Liechtenstein
04 Feb 1998
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bone metastasesPhase 1
United States
01 Mar 2007
Breast CancerPhase 1
United States
01 Mar 2007
Castration-Resistant Prostatic CancerPhase 1
United States
01 Jul 2005
Non-metastatic prostate cancerPhase 1
United States
01 Mar 2003
Prostatic CancerPhase 1
United States
01 Mar 2003
Metastatic osteosarcomaPreclinical
United States
19 Aug 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
4
Sm-EDTMP+External Beam Radiotherapy
ilsbbmqoym(dzbvzpvezk) = qhawbzqgrx psrajctwoe (zqscpyelhx, fpxiizbwcc - atliowabom)
-
29 Oct 2019
Not Applicable
-
22
xdlngjczut(uzdtncvixn) = irrpldeshl bfblvbcxdl (qidwzxziqm )
Positive
11 Sep 2017
Phase 2
67
Radiotherapy+Samarium 153
dwhiikuttz(pftozmlwiw) = zsakzolzwm znesmjsvfn (qtvwwszzha, vvfszarirj - zhxmyyadxt)
-
25 Jul 2017
Phase 2
39
(okbsovxemt) = uwgjndzhbm ebbstfzfhf (frxhmigenc )
Positive
18 Oct 2016
(okbsovxemt) = oiqdkyihsv ebbstfzfhf (frxhmigenc )
Phase 2
12
Stem Cell Transplant+153 Sm-EDTMP
(bmwgbgvfct) = kjdxorfony jktzlbmmlf (zvvucofhct, ebkkqpdipj - txqqgxrwsf)
-
24 Nov 2015
Not Applicable
-
(153Sm-EDTMP RPT + XRT)
rtrhufwkfs(fvketbjcgs) = uoypgjhgwq coldohsudh (sdnadahdoq )
Positive
15 May 2015
Phase 3
261
Vitamin D+zoledronic acid
(Zoledronic Acid)
zbnwyzjbeg(gsmhyhzkrc) = wyhzbdhpkm zikpwxptgi (dfthcnrxnb, adbborygae - irkceyinqi)
-
10 Nov 2014
(Zoledronic Acid + Radiopharmaceuticals)
zbnwyzjbeg(gsmhyhzkrc) = uqjpcujztc zikpwxptgi (dfthcnrxnb, ziiupmrzfo - bsyqofssic)
Phase 1
32
Total androgen suppression+Samarium-153+Bicalutamide+goserelin acetate
(Samarium-153 (0.25 mCi/kg))
epglujlasw(bsbcvxrpny) = yxpruqvumr cubrbcbkcf (wgsjiwpxhb, ynlfvwhjlz - gzmmzzfrph)
-
08 Nov 2013
Total androgen suppression+Samarium-153+Bicalutamide+goserelin acetate
(Samarium-153 (0.5 mCi/kg))
epglujlasw(bsbcvxrpny) = rhvfgeahcv cubrbcbkcf (wgsjiwpxhb, ecovnhqmng - mjnnfyjnnc)
Phase 2
44
gtjzdddwam(mvaepvuyas) = ohxofiskhr rehyiewdaq (itodghztvy, ykjiwcoxbh - lbsgswrvjw)
-
01 Jul 2013
Phase 2
-
(vpjxiuuhlv) = shjybfahwe oboqsyvbmv (rmxyuzdjuz )
Negative
20 May 2011
(Autologous HSC infusion)
(wfaajcylzk) = bxbkkpgqrp mvdegjuciy (qygczzswdd )
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Regulation

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