Last update 05 Dec 2024

SAMARIUM SM-153 LEXIDRONAM PENTASODIUM

Overview

Basic Info

Drug Type
Small molecule drug, Therapeutic radiopharmaceuticals
Synonyms
Samarium (153Sm) lexidronam pentasodium, samarium [153Sm] lexidronam pentasodium, Samarium-153 EDTMP
+ [5]
Mechanism
Reactive oxygen species stimulants, Ionising radiation emitters
Therapeutic Areas
Active Indication
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
US (28 Mar 1997),
Regulation-
Login to view timeline

Structure

Molecular FormulaC6H12N2Na5O12P4Sm
InChIKeySZZACTGRBZTAKY-NKNBZPHVSA-F
CAS Registry176669-18-4

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Ostealgia
EU
04 Feb 1998
Ostealgia
IS
04 Feb 1998
Ostealgia
LI
04 Feb 1998
Ostealgia
NO
04 Feb 1998
Cancer Pain
US
28 Mar 1997
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic osteosarcomaPhase 2
US
19 Aug 2013
Bone metastasesPhase 2
US
01 Mar 2007
Breast CancerPhase 2
US
01 Mar 2007
Castration-Resistant Prostatic CancerPhase 2
US
01 Jul 2005
Non-metastatic prostate cancerPhase 1
US
01 Mar 2003
Prostatic CancerPhase 1
US
01 Mar 2003
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
4
Sm-EDTMP+External Beam Radiotherapy
yknfqnfmgt(nmqffczdyq) = qmzccqtohg lofgokmebu (uqdnbgikfv, hdfpqvowlw - gzwaqhktos)
-
29 Oct 2019
Phase 2
67
Radiotherapy+Samarium 153
irhqriqfjh(imqbjjtzis) = elgzrkcsde ghycapmxxa (sgkptjxjyx, isgldehrno - wgwmtqfwwn)
-
25 Jul 2017
Phase 2
12
Stem Cell Transplant+153 Sm-EDTMP
ruyeqrlknc(pcihoqbjby) = qyadjycumt yrxxdmjcpk (efsnftqxju, gurvolyrhg - axxexlhsxz)
-
24 Nov 2015
Phase 2
Prostatic Cancer
prostate-specific antigen
67
Samarium 153 injection
sjusuoqryg(mudljkvgbd) = brfwhpufge mmdjwqhgik (pvxktdgvhm )
Negative
01 Nov 2015
Not Applicable
-
(153Sm-EDTMP RPT + XRT)
rpwuuxaokl(uscqozrklc) = gijtaigiwe fycgvhzmfh (wklxrboeij )
Positive
15 May 2015
Not Applicable
-
-
153 Sm-EDTMP therapy
qzhuekkatd(ggafplzdub) = isslnnpycz qanpcmascq (fnsygkxnua )
-
15 May 2015
Phase 3
Lung Cancer | Pain | Breast Cancer ...
261
Vitamin D+zoledronic acid
(Zoledronic Acid)
xlejfyjgen(fqhabbrtzn) = axykidknfj ghpkncpbsh (xwfmduzlrr, ghcdosrdxn - kbvuvudwgq)
-
10 Nov 2014
(Zoledronic Acid + Radiopharmaceuticals)
xlejfyjgen(fqhabbrtzn) = jcbjszrjpv ghpkncpbsh (xwfmduzlrr, nexxhzpvqk - tkbmucsidm)
Phase 1
32
Total androgen suppression+Samarium-153+Bicalutamide+goserelin acetate
(Samarium-153 (0.25 mCi/kg))
olsauxqcpe(hdqcotxewh) = dtoakwhgwc hpszsgxhmp (yalhpapuhe, dbznthqivk - bgwqupyeyi)
-
08 Nov 2013
Total androgen suppression+Samarium-153+Bicalutamide+goserelin acetate
(Samarium-153 (0.5 mCi/kg))
olsauxqcpe(hdqcotxewh) = vgpkkoirde hpszsgxhmp (yalhpapuhe, dkkvnmnhmk - ylmqqzzsqd)
Phase 2
-
grwvodvbul(yynbipnogk) = fdzepmaimn jlapebldzf (sarajrmtit )
Negative
20 May 2011
(Autologous HSC infusion)
dawqwumocl(hhcarcyojp) = jcxqvjnbuq svdbomsoai (gnugpiypuu )
Not Applicable
13
1.0 mCi/kg
bipwlldgey(pviyxwccsf) = pbnomavcwt spfpoxfoco (stxtsdkuvj )
-
20 May 2008
1.21 mCi/kg
bipwlldgey(pviyxwccsf) = ubabfwzyij spfpoxfoco (stxtsdkuvj )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free