Last update 06 Nov 2026

Avatrombopag Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
avatrombopag, Avatrombopag maleate (JAN/USAN), AKR-501
+ [17]
Action
agonists
Mechanism
TPO receptor agonists(Thrombopoietin receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (21 May 2018),
RegulationOrphan Drug (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC33H38Cl2N6O7S2
InChIKeyMISPBGHDNZYFNM-BTJKTKAUSA-N
CAS Registry677007-74-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic liver disease
Canada
03 Nov 2023
Purpura, Thrombocytopenic, Idiopathic
European Union
20 Jun 2019
Purpura, Thrombocytopenic, Idiopathic
Iceland
20 Jun 2019
Purpura, Thrombocytopenic, Idiopathic
Liechtenstein
20 Jun 2019
Purpura, Thrombocytopenic, Idiopathic
Norway
20 Jun 2019
Thrombocytopenia
United States
21 May 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Anemia, AplasticPhase 3-31 Jul 2026
Sveinsson Chorioretinal AtrophyPhase 3-31 Jul 2026
Primary thrombocytopeniaPhase 3
China
02 Mar 2021
Primary thrombocytopeniaPhase 3
China
02 Mar 2021
Primary thrombocytopeniaPhase 3
China
02 Mar 2021
Hematologic NeoplasmsPhase 3
United States
09 Oct 2018
Hematologic NeoplasmsPhase 3
United States
09 Oct 2018
Hematologic NeoplasmsPhase 3
United States
09 Oct 2018
Hematologic NeoplasmsPhase 3
Hungary
09 Oct 2018
Hematologic NeoplasmsPhase 3
Hungary
09 Oct 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
42
biaqhlmolc(egxkhutexg) = mteriaeprq ibsrauhdba (fopumbygbq )
Positive
05 Nov 2026
Not Applicable
208
bwlghljbvi(pedaujwvap) = Most patients (78%) reported no AEs. Eleven discontinued AVA due to AEs, most commonly headache (n=3) and ischaemic stroke (n=2). obyjzyktue (dpfjfuvuva )
Positive
13 Jul 2026
Not Applicable
142
gleawnollc(ymreidezoe) = one event of hepatotoxicity yjuggihauh (ykfodquubn )
Positive
12 Jul 2026
Not Applicable
46
fweedonlea(yasgchxwyw) = Avatrombopag was used perioperatively in 10.9% of patients to optimise platelet counts. No adverse events were reported in 80% of patients. Reported events were mild and included asthenia, LDH elevation, gastrointestinal symptoms, and cutaneous reactions. oqoowsrium (oznmqsfznm )
Positive
12 Jul 2026
Phase 2
-
47
ucqzkladzn(dumyazuoem) = uzzlbqcclc bfsjlqzzeu (xfvdnqjzfh )
Positive
29 May 2026
Placebo
ucqzkladzn(dumyazuoem) = mqufkrnilb bfsjlqzzeu (xfvdnqjzfh )
Phase 3
75
pmuddwnoca(ilyrlefkyw) = zbxlcopkdf pwsuuorerf (liikvuvgvw )
Positive
12 May 2026
Placebo
pmuddwnoca(ilyrlefkyw) = tkcgzlxrpg pwsuuorerf (liikvuvgvw )
Phase 4
28
Avatrombopag 20 mg every other day
wuyfvuwsoj(irdigmlndv) = mjvecutwzu mcjobexpbm (ayndrcyscn )
Positive
12 May 2026
Not Applicable
47
ujpuggasre(amcdnccyap) = one case of grade 1 persisting nausea and another with grade 1 hepatitis, resolved with a 20 mg dose reduction hswsucacqp (hlnkplteje )
Positive
12 May 2026
Phase 2/3
100
zyebgqgcpc(arvnqdjpho) = rkmstjuvcd cjoqsmwljf (tudkambuer )
Positive
06 Dec 2025
Placebo
zyebgqgcpc(arvnqdjpho) = ulbqiregmz cjoqsmwljf (tudkambuer )
Not Applicable
225
(convenience or AE occurrence)
hinewlldee(vzgabwilda) = Venous or arterial ischemic events were reported in 4 cases. Cephalea, thrombocytosis, myelofibrosis and liver toxicity led to AVA suspension in 6, 3, 2 and 2 cases, respectively. fybbkibvdp (njkapgrste )
Positive
06 Dec 2025
(due to lack of effectiveness of the previous TPO-RA)
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