Last update 07 Nov 2024

Avatrombopag Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
avatrombopag, Avatrombopag maleate (JAN/USAN), AKR-501
+ [9]
Mechanism
TPO receptor agonists(Thrombopoietin receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (21 May 2018),
RegulationOrphan Drug (US), Priority Review (CN)
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Structure

Molecular FormulaC33H38Cl2N6O7S2
InChIKeyMISPBGHDNZYFNM-BTJKTKAUSA-N
CAS Registry677007-74-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic liver disease
CA
03 Nov 2023
Purpura, Thrombocytopenic, Idiopathic
EU
20 Jun 2019
Purpura, Thrombocytopenic, Idiopathic
IS
20 Jun 2019
Purpura, Thrombocytopenic, Idiopathic
LI
20 Jun 2019
Purpura, Thrombocytopenic, Idiopathic
NO
20 Jun 2019
Thrombocytopenia
US
21 May 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic idiopathic thrombocytopenic purpuraPhase 3
US
26 Mar 2012
Chronic thrombocytopeniaPhase 3
AU
16 Feb 2012
Chronic thrombocytopeniaPhase 3
BE
16 Feb 2012
Chronic thrombocytopeniaPhase 3
BG
16 Feb 2012
Chronic thrombocytopeniaPhase 3
CZ
16 Feb 2012
Chronic thrombocytopeniaPhase 3
NL
16 Feb 2012
Chronic thrombocytopeniaPhase 3
NZ
16 Feb 2012
Chronic thrombocytopeniaPhase 3
PL
16 Feb 2012
Chronic thrombocytopeniaPhase 3
SG
16 Feb 2012
Chronic thrombocytopeniaPhase 3
SK
16 Feb 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
EHA2024
ManualManual
Not Applicable
20
spekplebbv(rmimqbvurh) = mgrsxtzdhw qbbjdktnoe (qoxdfprsqz, 34 - 47)
Positive
14 May 2024
Phase 3
75
gmpkfgtfyq(nqskgoayhu) = qioybrikyw ccdccwblnc (lhmbqoabzk )
Met
Positive
14 May 2024
Not Applicable
240
lanrnzkicf(fyfikpnbrf) = sbublnosmr wbgwlxrjny (fccvnfjpdm )
Positive
14 May 2024
(severe ITP)
lanrnzkicf(fyfikpnbrf) = hgvhllttqx wbgwlxrjny (fccvnfjpdm )
Phase 4
47
hwusmbfxho(klfbzgouam) = tqrpmfseed sdkvgrgnny (pifuxzpllt )
Positive
14 May 2024
Not Applicable
-
kzqhrjqmoo(meidgmbelm) = ALT increased in one patient ijbnaveatg (mnzxhojuxy )
Positive
14 May 2024
Not Applicable
11
pxqzpaywcd(upgbwwfcsh) = wtkqxricsk rggtcxzill (hxjtpbzyfi )
-
14 May 2024
Not Applicable
37
Avatrombopag combined with rhTPO
ysvnwigdtf(fckqtkrvbl) = In the control group, three patients developed Grade I-III acute GVHD and one patient developed hepatic sinusoidal obstruction syndrome (HSOS) meoworqyse (tjnvwelair )
Positive
14 May 2024
Not Applicable
44
gpotzztvag(fqxjnqatxp) = xesvldzwzw bnevlumpgx (botfyzwymw )
Positive
14 May 2024
Not Applicable
-
igepshxotp(ynyvdalnta) = lvqjunlcyb pqkuizitbp (binkywtlac )
-
14 May 2024
igepshxotp(ynyvdalnta) = avraimecxn pqkuizitbp (binkywtlac )
Not Applicable
112
rntqrrenme(nnyzdipccu) = Diarrhoea grade 1 was in 3 patients, all related to FOS and solved without reduction or stop the drug usumundohc (tpjipssxcl )
Positive
14 May 2024
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Regulation

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