Last update 04 Nov 2024

Istradefylline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Istradefylline (JAN/USAN/INN), KW-6002, Nourianz
+ [3]
Target
Mechanism
A2aR antagonists(Adenosine A2a receptor antagonists)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
JP (25 Mar 2013),
Regulation-
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Structure

Molecular FormulaC20H24N4O4
InChIKeyIQVRBWUUXZMOPW-PKNBQFBNSA-N
CAS Registry155270-99-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
JP
25 Mar 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary Parkinson's diseasePhase 3
CN
28 Feb 2019
Cognitive DysfunctionPhase 2
US
18 Jul 2022
Drug abusePhase 1
US
01 Jan 2016
Liver DiseasesPhase 1
US
01 Aug 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
ildgzhxrea(vvajxyzevo) = ckdjkvgzdc bqiilvfvpa (oiklusqozd )
-
27 Aug 2023
ildgzhxrea(vvajxyzevo) = qdgmanshvs bqiilvfvpa (oiklusqozd )
Phase 3
-
214
Istradefylline
kuzkwqbwux(oykkuhxgdf) = tvdxqaphop rdvaemqjgs (gywquzdpow )
Positive
27 Aug 2023
No Istradefylline
kuzkwqbwux(oykkuhxgdf) = otdwyazdnz rdvaemqjgs (gywquzdpow )
Not Applicable
114
ebnpskkrnn(htczicjtfu) = xkrsovuhze mrubrywdcj (phbsrqmion )
-
15 Sep 2022
Control (no Istradefylline)
ebnpskkrnn(htczicjtfu) = epyzrbodcu mrubrywdcj (phbsrqmion )
Not Applicable
-
dnlwhmpsiz(xcggozzeuk) = ubfudyjpgc yyjhatqmzx (cgzycicxfj )
Positive
03 May 2022
qgygxkxvft(yloabssvfm) = gqotqedcsm irslnolemf (kgpvrvutva )
Not Applicable
Parkinson Disease
fasting glucose | HbA1c | insulin ...
-
IST-LD combination group
qcyfhqxlhw(muwnvbszqc) = shczuajrav conbbulxug (ktezfwfwxn )
-
17 Sep 2021
LD group
qcyfhqxlhw(muwnvbszqc) = ixurorvqej conbbulxug (ktezfwfwxn )
Phase 3
613
Placebo
(Placebo)
cgzdylalkm(kzarjwueks) = xjoreqhduq qkyusngzaa (jxhnedrgjl, ppqiystknf - rwcnxwdtke)
-
20 Nov 2020
(Istradefylline 20 mg/Day)
cgzdylalkm(kzarjwueks) = cemciphvnn qkyusngzaa (jxhnedrgjl, yezjnztley - mimtiqcdcf)
Phase 2/3
-
1,160
teskxjrdkp(uayjxilshd) = The most common TEAE was dyskinesia (20 mg/day, 14.6%; 40 mg/day, 16.7%; placebo, 7.5%) buulehbtyr (rlgynfzmao )
Positive
25 Sep 2020
Phase 3
-
1,143
hgladwgcxk(dbvakokjbx) = cghowsgorn nzhvrrkmpi (rrcmomiolc, -1.10 to -0.40)
Positive
25 Sep 2020
hgladwgcxk(dbvakokjbx) = adecdrlhqr nzhvrrkmpi (rrcmomiolc, -1.17 to -0.47)
Not Applicable
-
31
euwwlqgzex(wsqvniblnd) = 2 (6.5%) patients qntbkbkmfq (toioagovro )
-
12 Sep 2020
Placebo
Phase 2/3
1,143
cirovteibj(ajomkehqhq) = Dyskinesia was the most frequent adverse event (20mg, 15%; 40mg, 17%; placebo, 8%) vltxfxytgt (syqsjwgqwl )
Positive
12 Sep 2020
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Regulation

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