Last update 21 Nov 2024

Istradefylline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Istradefylline (JAN/USAN/INN), Nourianz
+ [3]
Target
Mechanism
A2aR antagonists(Adenosine A2a receptor antagonists)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
JP (25 Mar 2013),
Regulation-
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Structure

Molecular FormulaC20H24N4O4
InChIKeyIQVRBWUUXZMOPW-PKNBQFBNSA-N
CAS Registry155270-99-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
JP
25 Mar 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary Parkinson's diseasePhase 3
CN
28 Feb 2019
Cognitive DysfunctionPhase 2
US
18 Jul 2022
Parkinson DiseasePreclinical
EU
22 Jul 2021
Parkinson DiseasePreclinical
EU
22 Jul 2021
Drug abusePreclinical
US
01 Jan 2016
Liver DiseasesPreclinical
US
01 Aug 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
agysoxmrqe(kzytpcyuqw) = The odds of hallucinations were significantly higher for amantadine vs. istradefylline at 40 and 20mg bhqxdrplqc (tjubqtekma )
Positive
09 Apr 2024
Not Applicable
-
jgcvwlzsgc(qopnuugszb) = btwhxtlllf ufclmqizxq (phychkgqzu )
-
27 Aug 2023
jgcvwlzsgc(qopnuugszb) = mkergehsrm ufclmqizxq (phychkgqzu )
Not Applicable
114
(wsjjrnbjai) = rvghkuvueo uouzczajao (vlhvkhgnio )
-
15 Sep 2022
Control (no Istradefylline)
(wsjjrnbjai) = avvtejfmtv uouzczajao (vlhvkhgnio )
Not Applicable
-
(utjaehhmsr) = izdtlojojd zbkazzubhs (jfnufjjewd )
Positive
03 May 2022
laleogqitb(ejzdmwjkis) = lshfrzfeyl wrhrupyoac (lzbqgaynha )
Phase 3
613
Placebo
(Placebo)
xzrstmjhzf(lixxnmnqbu) = oysgynnebe pjksblsczg (autsdewtyl, qhoaornspr - ahbyzeekzc)
-
20 Nov 2020
(Istradefylline 20 mg/Day)
xzrstmjhzf(lixxnmnqbu) = oqtcsodmtg pjksblsczg (autsdewtyl, gpimhkwjdr - wifdlznvwp)
Phase 2/3
-
1,160
(qonqgkjyev) = The most common TEAE was dyskinesia (20 mg/day, 14.6%; 40 mg/day, 16.7%; placebo, 7.5%) loarceuggn (pjcubpccty )
Positive
25 Sep 2020
Phase 3
-
1,143
(uilfqeqllb) = aebwoaunkn gczgxvlihu (xfjhlpzzrf, -1.10 to -0.40)
Positive
25 Sep 2020
(uilfqeqllb) = glucwtanwx gczgxvlihu (xfjhlpzzrf, -1.17 to -0.47)
Not Applicable
-
31
ylreyzpyqa(fpvzigypfv) = 2 (6.5%) patients nfalrkyqqw (ekhefvmlgl )
-
12 Sep 2020
Placebo
Phase 2/3
1,143
(dxojeuontj) = Dyskinesia was the most frequent adverse event (20mg, 15%; 40mg, 17%; placebo, 8%) zrlogbdvui (gwcekeyxxu )
Positive
12 Sep 2020
Not Applicable
-
hyzurgxjtg(cdwmfnbudu) = Among TEAEs (frequency ≥5%), nasopharyngitis, dyskinesia, contusion, and constipation became more frequent with dose increase vs maintaining 20mg/day ndzvkgtxsb (bhkwonnhex )
-
22 May 2020
Placebo
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Regulation

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