Last update 22 May 2025

SIBP-A19

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
SIBP-A19
Target
FOLR1 x Top I
Action
antagonists, inhibitors
Mechanism
FOLR1 antagonists(Folate receptor alpha antagonists), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Therapeutic Areas
NeoplasmsEndocrinology and Metabolic DiseaseRespiratory Diseases+ [1]
Active Indication
Advanced Malignant Solid NeoplasmEndometrial CarcinomaNon-Small Cell Lung Cancer+ [1]
Inactive Indication-
Originator Organization
Shanghai Institute of Biological Products Co., Ltd.Shanghai Institute of Biological Products Co., Ltd.
Active Organization
Shanghai Institute of Biological Products Co., Ltd.Shanghai Institute of Biological Products Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC26H24FN3O6
InChIKeyPLXLYXLUCNZSAA-QLXKLKPCSA-N
CAS Registry1599440-33-1
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Related

1
Clinical Trials associated with SIBP-A19
CTR20252021
/ Not yet recruitingPhase 1
注射用SIBP-A19治疗晚期恶性实体瘤患者的安全性、耐受性、药代动力学和初步疗效的I期临床研究
[Translation] Phase I clinical study on the safety, tolerability, pharmacokinetics and preliminary efficacy of SIBP-A19 for injection in the treatment of patients with advanced malignant solid tumors
100 Clinical Results associated with SIBP-A19
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100 Translational Medicine associated with SIBP-A19
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100 Patents (Medical) associated with SIBP-A19
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100 Deals associated with SIBP-A19
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1
China
Shanghai Institute of Biological Products Co., Ltd.Shanghai Institute of Biological Products Co., Ltd.
21 May 2025
Endometrial CarcinomaIND Approval
China
Shanghai Institute of Biological Products Co., Ltd.Shanghai Institute of Biological Products Co., Ltd.
24 Jan 2025
Non-Small Cell Lung CancerIND Approval
China
Shanghai Institute of Biological Products Co., Ltd.Shanghai Institute of Biological Products Co., Ltd.
24 Jan 2025
Ovarian CancerIND Approval
China
Shanghai Institute of Biological Products Co., Ltd.Shanghai Institute of Biological Products Co., Ltd.
24 Jan 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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