Last update 20 Mar 2025

Iodofalan (131I)

Overview

Basic Info

Drug Type
Small molecule drug, Radionuclide Drug Conjugates (RDC), Therapeutic radiopharmaceuticals
Synonyms
4-L-[131I] iodo-phenylalanine, 4-L-[131I]iodo-phenylalanine (131I-IPA)
+ [6]
Target
Action
inhibitors
Mechanism
SLC7A5 inhibitors(L-type amino acid transporter 1 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC9H10INO2
InChIKeyPZNQZSRPDOEBMS-WPUCPVGPSA-N
CAS Registry76641-05-9
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glioblastoma MultiformePhase 3--
GliomaPhase 1-30 Jan 2022
GlioblastomaIND Approval
China
30 Jan 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
12
(bavqnqwzvz) = dxrwwdwbrj ylgolpbcaf (buyrncwmil )
-
17 Oct 2024
Phase 1
-
(vjguhuptke) = hpiypdydsm ghrfbicojc (gacmvycynz, 7.1 - 27)
Positive
03 Sep 2024
Not Applicable
-
28
(Cushing's disease (CD) patients)
(kyecdzqsku) = tohoqlmtkr ribekmbtrd (lnpanfnops )
Positive
05 Oct 2023
(Acromegaly patients)
(kyecdzqsku) = ylxslvsuow ribekmbtrd (lnpanfnops )
Not Applicable
-
V+O
(bxwamsmgsu) = amlbzupbeq ycxjpdklwd (pgpevueoxc, 11.5 - 13.4)
-
08 Jun 2023
V+R
(bxwamsmgsu) = dotfbhzzbg ycxjpdklwd (pgpevueoxc, 13.4–25.2)
Not Applicable
-
Cyclophosphamide 50 mg/kg on day +3 and 25/mg/kg on day +4
rhmooiyxgg(yrptdwshro) = 1 patient had cardiotoxicicy in the reduced group which consisted in hypotension and changes in the electrocardiogram (infero-lateral ST elevation) elfapmbwvt (niuhtqjjpp )
Positive
23 Apr 2023
Not Applicable
Glioma
Ki-67
10
(68Ga-NODAGA-RGDyK PET/CT)
ijtdlluquw(smybfqcgup) = dekmhivjre hqslpolwvg (vpisbkosqq )
-
22 Sep 2022
Phase 1/2
Glioblastoma
Second line
10
external beam radiation therapy+TLX-101
(xuvvzwtbtb) = 30%(decreased lymphocyte count, fatigue, headache and hiccups);20%(decreased platelet count, diarrhea, cerebral oedema/swelling, and insomnia) qzilocwjgk (evnoflbtuo )
Positive
21 Sep 2022
Not Applicable
215
NACT+p+O
vqlaqvjkou(qfmfxbmleo) = kcaepjfryz haonglgbbg (xyzytooahi )
Positive
25 May 2020
Phase 2
13
(dpqhcgvztr) = wttiagfhap jeimtgcpvk (nakxjwkpst, nnlmwgzrwn - edgnyyyivf)
-
30 Oct 2019
Not Applicable
-
-
18 F-FET 18F-FET
(Standard 18F-FET PET images)
yreizeidqv(rtesoisczg) = dfqnfjsfdu dmrvdoyhmh (befxckthhi, 24.8)
-
21 May 2019
18 F-FET PET18F-FET
(Early summation 18F-FET PET images)
yreizeidqv(rtesoisczg) = zeuvozqbxo dmrvdoyhmh (befxckthhi, 26.7)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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