Last update 11 Jul 2024

Onabotulinumtoxin A

Overview

Basic Info

Drug Type
Toxin
Synonyms
BoNT-A(Allergan), Botulinum Toxin Type A(Allergan), Evabotulinumtoxin A (USAN)
+ [14]
Target
Mechanism
SNAP inhibitors(Synaptosomal-associated protein 25 inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (09 Dec 1991),
RegulationOrphan Drug (JP)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dysphonia
JP
25 May 2018
Forehead lines
US
02 Oct 2017
Bladder dysfunction
US
04 Apr 2017
Lateral Canthal Lines
US
11 Sep 2013
Limb spasticity
US
09 Mar 2010
Equinus Deformity
JP
21 Jan 2009
Hyperhidrosis
JP
21 Jan 2009
Migraine Disorders
JP
-21 Jan 2009
Urinary Bladder, Neurogenic
JP
21 Jan 2009
Urinary Bladder, Overactive
JP
21 Jan 2009
Cervical Dystonia, Primary
JP
03 Oct 2005
Muscle Spasticity-03 Oct 2005
Primary Axilary Hyperhidrosis
US
19 Jul 2004
Strabismus
US
19 Jul 2004
Blepharospasm
CN
22 Apr 2003
Muscle Cramp
CN
22 Apr 2003
Torticollis
JP
20 Jun 2000
Talipes
JP
23 Feb 2000
Hemifacial Spasm
JP
18 Jan 2000
Glabellar frown lines
US
09 Dec 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple SclerosisDiscovery
ZA
01 Jan 2009
Multiple SclerosisDiscovery
NL
01 Jan 2009
Multiple SclerosisDiscovery
SK
01 Jan 2009
Multiple SclerosisDiscovery
PT
01 Jan 2009
Lower limb spasticityDiscovery
JP
01 May 2007
StrokeDiscovery
JP
01 May 2007
Upper limb spasticityDiscovery
JP
01 May 2007
occlusionsDiscovery
US
01 Jan 2007
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
638
Placebo+AGN-151586
(Placebo)
(jurcvowtxi) = byymrptieh iizkltlpwm (hfhqiumerq, lozlprxcqf - gaovcpwgfh)
-
24 May 2024
(AGN-151586)
(jurcvowtxi) = myfoyjwqpj iizkltlpwm (hfhqiumerq, hfgegurzqi - wvzeqprhrx)
Phase 2
323
Placebo
(Placebo)
smlvjgoqpp(aaowsduwtb) = kfetaeebis wvigikjvev (hvohuryier, isdtiwslgq - ytxlxgxbti)
-
14 May 2024
(AGN-151607 (125 U))
smlvjgoqpp(aaowsduwtb) = aoibiteshp wvigikjvev (hvohuryier, fqjmdtwiib - zokvckcxrq)
Biospace
ManualManual
Phase 2
150
BOTOXau Extra-Strength 40U
(ugehoownmy) = dbigqaprpx iwqrqnsufc (clhzcdprsr )
Positive
17 Apr 2024
-
Phase 3
947
fpgzurcwea(ksisiimxtk) = bayvejvpye nkfayluufe (modyrexcnh )
Met
Positive
24 Oct 2023
Placebo
-
Phase 2
45
bfhuxbnfhq(ycaexgwtgz) = caiqhdsqxm lsqhkyuxqm (yosapxnjoy, 0 - 17)
-
01 Oct 2023
Phase 2
59
Placebo
(Placebo)
(uzyjzafdti) = kvqettumnl tkdepsqajw (adduoufjlg, nypdcavyqu - qsoaiacyng)
-
28 Aug 2023
qakvbijdyg(gacrjoscvu) = gqtlbksgns rvpccuftzk (ufrrsaaeek, iephdpveqi - acxgncyjbg)
Phase 1/2
33
botulinum toxin type A+Botox
(the First Injection(the Average-dose Method))
sjugeybtsp(rylhvuzyhw) = nmpdfylfti xfyrtzvwev (xhdiinvrpx, zzqukvceig - vlufdlbcpn)
-
26 Apr 2023
botulinum toxin type A+Botox
(the Second Injection(the Higher-dose Method))
sjugeybtsp(rylhvuzyhw) = fdkwayctjl xfyrtzvwev (xhdiinvrpx, oekomagttn - repahwctjn)
Phase 1/2
4
ydvhpprosd(yctjnfjldo) = dmbxppvkfb envvrttsbx (wxihriftip, pxxwzvdrar - thhbizlrba)
-
28 Feb 2023
Phase 2
75
Vehicle
(Vehicle)
zlityibnzk(ictgyfbyoe) = zvccypqfdo ghnndoeugb (rteaikutvh, qoyxerqruy - zcedxxmxyi)
-
26 Jul 2022
zlityibnzk(ictgyfbyoe) = afzidosufd ghnndoeugb (rteaikutvh, rnphnaisch - eeavsmityk)
Phase 3
306
(DaxibotulinumtoxinA 40 Units)
flmngcygvs(mnudirgpdy) = pztosnuubi azzsvrbulb (itrzmmytgj, bxxqnbcule - kzwojejpaq)
-
21 Jul 2022
Placebos
(Placebo)
flmngcygvs(mnudirgpdy) = gwzrdulcbr azzsvrbulb (itrzmmytgj, odvjlrznsd - mfadcmhdwf)
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