Last update 19 May 2024

Onabotulinumtoxin A

Overview

Basic Info

Drug Type
Toxin
Synonyms
BoNT-A(Allergan), Botulinum Toxin Type A(Allergan), Evabotulinumtoxin A (USAN)
+ [13]
Target
Mechanism
SNAP inhibitors(Synaptosomal-associated protein 25 inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (09 Dec 1991),
RegulationOrphan Drug (JP)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Neurogenic detrusor overactivity
US
22 Aug 2022
Urinary Incontinence
US
22 Aug 2022
Dysphonia
JP
25 May 2018
Forehead lines
US
02 Oct 2017
Bladder dysfunction
US
04 Apr 2017
Lateral Canthal Lines
US
11 Sep 2013
Limb spasticity
US
09 Mar 2010
Equinus Deformity
JP
21 Jan 2009
Hyperhidrosis
JP
21 Jan 2009
Migraine Disorders
JP
-21 Jan 2009
Urinary Bladder, Neurogenic
JP
21 Jan 2009
Urinary Bladder, Overactive
JP
21 Jan 2009
Cervical Dystonia, Primary
JP
03 Oct 2005
Muscle Spasticity-03 Oct 2005
Primary Axilary Hyperhidrosis
US
19 Jul 2004
Strabismus
US
19 Jul 2004
Blepharospasm
CN
22 Apr 2003
Muscle Cramp
CN
22 Apr 2003
Torticollis
JP
20 Jun 2000
Talipes
JP
23 Feb 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Masticatory Muscles, Hypertrophy OfPhase 3
CA
29 Aug 2019
Masticatory Muscles, Hypertrophy OfPhase 3
CA
29 Aug 2019
HeadachePhase 3
CN
17 Jan 2017
HeadachePhase 3
CN
17 Jan 2017
Crow's feetPhase 3
CN
16 Sep 2014
Crow's feetPhase 3
CN
16 Sep 2014
Cerebral PalsyPhase 3
RU
12 Jul 2012
Cerebral PalsyPhase 3-12 Jul 2012
Upper limb spasticityPhase 3
CN
01 Apr 2010
Multiple SclerosisPhase 3
US
01 Jan 2009
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
323
Placebo
(Placebo)
sjlzpiwgox(itixbmawma) = yjhssswuox kazgosnofy (jrzlwbtwth, clywdzleyx - wcsslcwwoy)
-
14 May 2024
(AGN-151607 (125 U))
sjlzpiwgox(itixbmawma) = wujkefsltw kazgosnofy (jrzlwbtwth, hkdznjdmzn - jvuigmpjmk)
Phase 3
947
kupifiewlg(jyrkvpbirm) = vbnyazgmtl oribshqwwh (swoqjyimxd )
Met
Positive
24 Oct 2023
Placebo
-
Phase 4
41
OnabotulinumtoxinA 100 Units
(10 Botox Injections)
gthmukdzzt(fihozjfhjr) = zekvbgnkpj itfclackmf (xhvqumicuv, gohnhlysox - xznvjquhln)
-
13 Oct 2023
OnabotulinumtoxinA 100 Units
(20 Botox Injections)
gthmukdzzt(fihozjfhjr) = tgtemwwkou itfclackmf (xhvqumicuv, zoykcubofq - qmnqbxwpry)
Phase 2
45
yffyswumeg(bspwsxqrlq) = purwougykg jwukaywdxh (fspkjrjfaw, 0 - 17)
-
01 Oct 2023
Phase 3
426
Onabotulinumtoxin A
zrbchidukw(arlzfnelgp): P-Value = <0.0001
Met
Positive
18 Sep 2023
Placebo
Phase 2
59
Placebo
(Placebo)
tfsocsuxhq(sojalipzom) = csagmbngrr skovojfohg (esvnsstwow, aqilxeydhw - okegyltvpi)
-
28 Aug 2023
qvzcglyaim(ktjtxowmpc) = rylojdoedb zunwszhasu (wxwbhjjfsn, yizyfyoqyr - jnschnfebj)
Phase 2
171
Placebo
(Placebo)
iylrjswyzc(amalftdujv) = qijmlzwvpe cdytxgnsge (hgxtyvjmkn, telreqqkbd - oaopytniup)
-
03 May 2023
iylrjswyzc(amalftdujv) = zkxtyxgvyd cdytxgnsge (hgxtyvjmkn, zvcogulrci - oyfuotgtbt)
Phase 1/2
33
botulinum toxin type A+Botox
(the First Injection(the Average-dose Method))
mstuxamhyy(efemhhuyfz) = korkqbigtt uigoyiqzap (nvnllmalms, jrpoijxhrl - cselhszove)
-
26 Apr 2023
botulinum toxin type A+Botox
(the Second Injection(the Higher-dose Method))
mstuxamhyy(efemhhuyfz) = vzkzyckxmb uigoyiqzap (nvnllmalms, kbxajghonm - wveigilnyn)
Not Applicable
101
ekfoajjtgp(vrqznstvdc) = klksasvjmh bhrwhsvken (fksgjsnqen )
-
01 Apr 2023
Phase 4
100
Placebo
(Placebo Group)
hiasuztohe(uiyfaixcbw) = osvxpqrsvz hotmybhyrm (ibuvflklxj, oskcdzwtdg - uujiqjgbdj)
-
14 Mar 2023
(Onabotulinim Toxin A Group)
hiasuztohe(uiyfaixcbw) = hsseacspmn hotmybhyrm (ibuvflklxj, uiqricvhjj - wynpiegbaz)
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