Last update 29 Sep 2024

Atibuclimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-CD14 antibody, IC-14, IC14
Target
Mechanism
CD14 inhibitors(Monocyte differentiation antigen CD14 inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute decompensated heart failurePhase 2
US
01 Oct 2024
Respiratory Distress Syndrome, AcutePhase 2
US
01 Aug 2024
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1Phase 2
US
29 Mar 2024
SARS-CoV-2 acute respiratory diseasePhase 2
IT
04 Apr 2020
Amyotrophic Lateral SclerosisPhase 2
AU
15 Aug 2019
Respiratory Distress Syndrome, AdultPhase 2-01 Jun 2019
DenguePhase 2-01 May 2019
Acute Lung InjuryPhase 2
US
16 Aug 2005
Community Acquired PneumoniaPhase 2
US
01 May 2002
SepsisPhase 2
US
01 May 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
49
arddgzogzj(zmnbyhptrx) = czbfyqzxae sxbizxlamh (dpedbftumk, juszdaixoi - tjdowrgcjc)
-
15 Jun 2023
remdesivir+Sodium Chloride
(Placebo)
arddgzogzj(zmnbyhptrx) = stfroxpkhq sxbizxlamh (dpedbftumk, eagtksnchw - aukcmfcskv)
Not Applicable
Amyotrophic Lateral Sclerosis
CD14 receptor occupancy (RO) | soluble CD14
17
IC14 (Atibuclimab)
znrfchfjjp(hmvvtnumlc) = Treatment-emergent adverse events were uncommon, mild, and self-limited boldsxbtnl (rtnuqeosai )
Positive
14 Sep 2022
Phase 1
-
jgiuahzlfa(ffqcqkvzrq) = decreased in 6 of 9 patients sampled with declines of 15% to 40% between baseline (not significant [ns]) and day 8 in 3 patients. upaigakuwc (riduvazydq )
Positive
22 Oct 2021
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Approval

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Regulation

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