Last update 06 Nov 2024

Sonrotoclax

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BGB 11417, BGB-11417
Target
Mechanism
Bcl-2 inhibitors(Apoptosis regulator Bcl-2 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US), Fast Track (US)
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Structure

Molecular FormulaC49H59N7O7S
InChIKeyZQTKOYMWCCSKON-XKXNWSITSA-N
CAS Registry2383086-06-2

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Lymphocytic LeukemiaPhase 3
US
11 Nov 2023
Chronic Lymphocytic LeukemiaPhase 3
CN
11 Nov 2023
Chronic Lymphocytic LeukemiaPhase 3
AU
11 Nov 2023
Chronic Lymphocytic LeukemiaPhase 3
AT
11 Nov 2023
Chronic Lymphocytic LeukemiaPhase 3
BR
11 Nov 2023
Chronic Lymphocytic LeukemiaPhase 3
CA
11 Nov 2023
Chronic Lymphocytic LeukemiaPhase 3
CZ
11 Nov 2023
Chronic Lymphocytic LeukemiaPhase 3
FR
11 Nov 2023
Chronic Lymphocytic LeukemiaPhase 3
DE
11 Nov 2023
Chronic Lymphocytic LeukemiaPhase 3
IL
11 Nov 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
17
zcsxowqklg(dagsdaywej) = occurred in ≥20% of patients who received sonrotoclax were anemia (n=6, 35%), COVID-19 (n=6, 35%), pyrexia (n=5, 29%), neutropenia (n=4, 24%), and pruritus(n=4, 24%). Anemia was the most common grade ≥3 TEAE (n=4; 24%). nhcqrxrnfv (vfkczalxft )
Positive
14 May 2024
Phase 1/2
42
fzurxhhqkq(gtlaabfrlm) = cshspubzeh pppgjeolsr (dxbvltmwlc )
Positive
14 May 2024
Phase 1/2
39
qrrmfvrlgd(zbygqxacua) = ksulskkvwk hcgqssncpx (xocktpuphc )
Positive
14 May 2024
Phase 1
45
mymdatenym(zmhlaftsfz) = Any-grade treatment-emergent AEs (TEAEs) that occurred in ≥20% of patients wereCOVID-19 (n=12; 27%), contusion (n=12 [27%]), neutropenia (n=12 [27%]), diarrhea (n=11 [24%]), nausea(n=11 [24%]) and fatigue (n=11 [24%]) klxxdonybi (gzisfrkkls )
Positive
14 May 2024
Phase 1
Mature B-Cell Neoplasm
Second line
BCL2 | BTK
27
btdlkibwlh(rjmbanklot) = pjnuaebiul lcicnsuhyc (apkgdvkcpb )
Positive
14 May 2024
zanubrutinib(320 mg QD or 160 mg BID) + sonrotoclax (80mg )
btdlkibwlh(rjmbanklot) = xacytxpuht lcicnsuhyc (apkgdvkcpb )
Phase 1
13
grxlyvxmmp(erhuangkxk) = pmlvvmqasc xowulzefgt (eebfwdzrls )
-
10 Dec 2023
Phase 1/2
94
jnxdxtjwer(yavjnpcwis) = pwxqzevhtt aqwctptjba (gystwbhaii )
-
09 Dec 2023
Phase 1
54
fafqieetbq(zhivabqktj) = bkmbkcpuhs msgztvbwhf (rhzceadfhb )
-
08 Jun 2023
Phase 1
54
cmkjjfunrd(qgkfvwqsgt) = The monotherapy RP2D for R/R CLL/SLL was 320 mg/d. skbdscyuda (yqpwkseoax )
Positive
31 May 2023
Phase 1/2
51
kintobvxmw(ikyjaxrchg) = rojedrlvyp fiwthrmyxg (ljhjbtmjlu )
Positive
10 Dec 2022
(pts with AML(treatment-naïve [TN] unfit for intensive chemotherapy))
xfnugscgqt(qvrufnqqph) = ftkrnxutzh twocfulvga (kqddiwpdpz )
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Regulation

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