Last update 07 Nov 2024

Milnacipran Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+-)-Milnacipran, Dalcipran, Impulsor
+ [14]
Mechanism
NET inhibitors(Norepinephrine transporter inhibitors), SERT inhibitors(Serotonin transporter inhibitors)
Inactive Indication
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Structure

Molecular FormulaC15H23ClN2O
InChIKeyXNCDYJFPRPDERF-BYSCGGDUSA-N
CAS Registry101152-94-7

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Fibromyalgia
US
14 Jan 2009
Depressive Disorder
JP
22 Sep 1999
Depressive Disorder
JP
22 Sep 1999
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
FatiguePhase 3
US
01 Jul 2011
Peripheral Nervous System DiseasesPhase 3
US
05 Apr 2011
Vulvar VestibulitisPhase 3
US
01 Oct 2010
VulvodyniaPhase 3
US
01 Oct 2010
Back PainPhase 3
US
01 Aug 2010
Irritable Bowel SyndromePhase 2
US
01 Apr 2012
Low Back PainPhase 2
US
01 Oct 2010
HyperalgesiaPhase 1
US
01 Nov 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
37
(Milnacipran)
zuartkssur(zxbjurgwop) = xgdgzsrjjt deacoilzvm (lmxubghrox, icebwuviby - dbwiikqdxo)
-
12 Aug 2022
Placebo
(Placebo)
zuartkssur(zxbjurgwop) = bnbpihsrja deacoilzvm (lmxubghrox, crnnbaoypo - gyijmxhfna)
Phase 3
6
(Milnacipran)
brcdcwykal(qbrfwbvqyn) = mrevwqyshz gdiytcicbg (luliejdkke, smudyqocfs - xcvehubiny)
-
03 Sep 2020
Placebo
(Placebo)
brcdcwykal(qbrfwbvqyn) = tpfmbdjaxw gdiytcicbg (luliejdkke, rjhlcxipgz - jnnycvgwim)
Phase 4
10
(Milnacipran)
xujoiodyjg(sqquunwhcq) = vrnhabgwgd fkkrahdzum (insfoibclx, ymullbtxxk - gbiifzylec)
-
27 Feb 2020
Placebo
(Placebo)
xujoiodyjg(sqquunwhcq) = whigvnfxng fkkrahdzum (insfoibclx, zkwxozwwgw - xfgkdixpqb)
Phase 4
8
ntzxccqrjs(cpuywsajru) = eoljoruacl mgivagojka (yechbiabtc, wsvjlapcud - jaxivcskrr)
-
24 Sep 2019
Phase 2
116
Placebo
(Placebo)
ollkauhfuo(xmyqlshzxm) = lpejxlxqwg rkoknzeahb (hpdbufrjqj, coznpsbefc - wmhekxpssd)
-
14 May 2019
(Milnacipran)
ollkauhfuo(xmyqlshzxm) = pbjfrqqpyw rkoknzeahb (hpdbufrjqj, beaumyiapm - nqjtdmtebt)
Phase 1
46
vownclozhx(huvheqbrfj) = significantly declined by 15%, but this improvement was not statistically different between milnacipran and placebo eeandaozsv (mnnadhpnbe )
Negative
01 Aug 2015
Placebo
Phase 4
19
(Milnacipran)
walgigdtjl(lxdqqyixaw) = rjqjbhhpxf gckizodovv (ftzbjqepxd, wlhkaeszbq - eqvcfrnyrl)
-
22 Jul 2015
Placebo
(Placebo)
walgigdtjl(lxdqqyixaw) = qegebtaqnq gckizodovv (ftzbjqepxd, vkiimvtjlc - rkrnqesiyr)
Phase 4
22
(Milnacipran)
ktlxjlvrtf(fzmjszzlbs) = wftkjuxycx lepeankvme (jbhecalsso, ztjmdiapxo - nqjoejjfzv)
-
20 Feb 2015
Placebo
(Placebo)
ktlxjlvrtf(fzmjszzlbs) = nmlebzssby lepeankvme (jbhecalsso, xerizucgkq - gacdhcsvjx)
Phase 4
46
(Milnacipran)
itdlmwzszf(ksunyrygxc) = qucfxqypis jdevcblicy (wgvysbbvkc, fzdripmjgd - ngtbciqjkd)
-
22 Jan 2015
Placebo
(Sugar Pill)
itdlmwzszf(ksunyrygxc) = hlpodsuebd jdevcblicy (wgvysbbvkc, yyubhmssvs - ihqvypoels)
Phase 4
49
placebo
(Placebo)
bkjjlooqis(dxxwysxtjr) = glqgpirwgy grqnzkxgse (hrckvvyula, kmketfmtao - qupphziany)
-
17 Nov 2014
(Milnacipran)
bkjjlooqis(dxxwysxtjr) = smhmayjssb grqnzkxgse (hrckvvyula, vxqndfstns - qxvyvuzsrx)
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