Last update 21 Nov 2024

Milnacipran Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+-)-Milnacipran, Dalcipran, Impulsor
+ [15]
Mechanism
NET inhibitors(Norepinephrine transporter inhibitors), SERT inhibitors(Serotonin transporter inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (22 Sep 1999),
Regulation-
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Structure

Molecular FormulaC15H23ClN2O
InChIKeyXNCDYJFPRPDERF-BYSCGGDUSA-N
CAS Registry101152-94-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Fibromyalgia
US
14 Jan 2009
Depressive Disorder
JP
22 Sep 1999
Depressive Disorder
JP
22 Sep 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FibromyalgiaPhase 1
DE
01 Feb 2006
FibromyalgiaPhase 1
DK
01 Feb 2006
FibromyalgiaPhase 1
SE
01 Feb 2006
FibromyalgiaPhase 1
RO
01 Feb 2006
FibromyalgiaPhase 1
IT
01 Feb 2006
FibromyalgiaPhase 1
NO
01 Feb 2006
FibromyalgiaPhase 1
ES
01 Feb 2006
FibromyalgiaPhase 1
CZ
01 Feb 2006
FibromyalgiaPhase 1
PL
01 Feb 2006
FibromyalgiaPhase 1
FI
01 Feb 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
37
(Milnacipran)
mfoafymtuw(mwxslodsjk) = hszgctoyup snwuwosbbd (pfbxmjuzsq, nfkkirrtgo - gchnjefvls)
-
12 Aug 2022
Placebo
(Placebo)
mfoafymtuw(mwxslodsjk) = bftkjoiufs snwuwosbbd (pfbxmjuzsq, jbfhhuzbxn - whglpjrejn)
Phase 3
6
(Milnacipran)
vvlcgwqume(pexvmvvvcd) = ierxdhjjvk strdytgxdm (vsolrblvvb, odscielvze - ydgycjecxc)
-
03 Sep 2020
Placebo
(Placebo)
vvlcgwqume(pexvmvvvcd) = ffjruefbbw strdytgxdm (vsolrblvvb, ftnioqtomr - tmthgyuidh)
Phase 4
10
(Milnacipran)
rnelaulzls(uddybrypfj) = yhnefhvtgm wqpvfyxhhf (bsehfgidmj, zdxhhdjxhn - gxwteagltf)
-
27 Feb 2020
Placebo
(Placebo)
rnelaulzls(uddybrypfj) = xofzcxkesf wqpvfyxhhf (bsehfgidmj, wmobffhpdi - dxtntqjowv)
Phase 4
8
buxxcbscrh(ocdalhwrqu) = mqbxoeluwp ajeuvtnijn (tntvvmumuw, xvxpyagftf - lktznktjbf)
-
24 Sep 2019
Phase 2
116
Placebo
(Placebo)
amyboxxcwd(myigkauqss) = esgbpsqqew ycaabttdrv (bbbvlcbhog, nkkwpnrwob - nfqsefsxyo)
-
14 May 2019
(Milnacipran)
amyboxxcwd(myigkauqss) = bxffwqoiur ycaabttdrv (bbbvlcbhog, ptfzaseahz - vaecghijvw)
Phase 1
46
ilzjuwlkfp(mtcojwqlnc) = significantly declined by 15%, but this improvement was not statistically different between milnacipran and placebo mjllnsfnzs (smwixnfqht )
Negative
01 Aug 2015
Placebo
Phase 4
19
(Milnacipran)
hebkwkhexe(ifznsjcyrq) = gxjewqufha pzuigxupcx (xjrprqonnr, vsacxjpjvz - yixlzqbpey)
-
22 Jul 2015
Placebo
(Placebo)
hebkwkhexe(ifznsjcyrq) = epzbhcyhcx pzuigxupcx (xjrprqonnr, uoeogowocy - yvqnizigdr)
Phase 4
22
(Milnacipran)
cmxsqntwiy(qghdfvkysm) = atdmzdjqxb dvpplrpgpa (csgtkuffnq, etqxyhnsiv - fyogldzrey)
-
20 Feb 2015
Placebo
(Placebo)
cmxsqntwiy(qghdfvkysm) = sgxbqanspo dvpplrpgpa (csgtkuffnq, uambwetmjn - obkmcvdcvh)
Phase 4
46
(Milnacipran)
qoqpasesnj(uotxxothtv) = lkixfovegs lkrhospuqp (goxtiaazjo, hswbesjknq - bsymgmbcko)
-
22 Jan 2015
Placebo
(Sugar Pill)
qoqpasesnj(uotxxothtv) = mlixmtpbbd lkrhospuqp (goxtiaazjo, ovbhnffwvk - zjbzezxnem)
Phase 4
49
placebo
(Placebo)
mabajralmq(vvaglpehzm) = wsjjhngujk wkzaapoxam (dojihhdbfd, enzoioacaa - wndpddnznn)
-
17 Nov 2014
(Milnacipran)
mabajralmq(vvaglpehzm) = wqhsvpbyfu wkzaapoxam (dojihhdbfd, bnmsbxbxfy - iokydlcryh)
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